Results 31 to 40 of about 4,163 (290)

Stereoselective Total Synthesis of the Cyanobacterial Hepatotoxin 7-Epicylindrospermopsin:  Revision of the Stereochemistry of Cylindrospermopsin

, 2016
Stereoselective Total Synthesis of the Cyanobacterial Hepatotoxin 7-Epicylindrospermopsin:  Revision of the Stereochemistry of ...
Grier A. Wallace (2365516), Stephen P. Keen (2029042), Steven M. Weinreb (1651984), Wen-Kui Fang (2985288), Geoffrey R. Heintzelman (2531518)   +4 more
core   +1 more source

Opposing effects of prednisolone treatment on T/NKT cell- and hepatotoxin-mediated hepatitis in mice

, 2014
Prednisolone is a corticosteroid that has been used to treat inflammatory liver diseases such as autoimmune hepatitis and alcoholic hepatitis. However, the results have been controversial, and how prednisolone affects liver disease progression remains ...
H J Kwon, Young Suk Won, B Gao, D Feng, O Park   +4 more
core   +1 more source

The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

iScience, 2020
Summary: The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the ...
Takashi Kato, Tatsuya Yamada, Hideki Nakamura, Atsushi Igarashi, Robert A. Anders, Hiromi Sesaki, Miho Iijima   +6 more
doaj   +1 more source

Oxidative stress biomarkers in Clarias gariepinus (Burchel, 1822) exposed to Microcystin-LR

Beni-Suef University Journal of Basic and Applied Sciences, 2017
Stress levels inflicted by microcystin-LR extracted from Microcystis aeruginosa were assessed by estimating the effects on the oxidative stress biomarkers in the liver, muscle and gill tissues of Clarias gariepinus. Microcystin-LR was administered to the
Patrick Omoregie Isibor
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Marked inhibition of testosterone biosynthesis by the hepatotoxin nodularin due to apoptosis of Leydig cells.

, 2002
We previously observed that the serum testosterone level was greatly reduced in the course of diethylnitrosamine-nodularin-induced hepatocarcinogenesis in Fischer 344 male rats (Lim et al., Gastroenterological Carcinogenesis, 1999).
Sohn, SH, Lim, IK, Song, KY, Park, TJ
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Hepatotoxin-induced hypertyrosinemia and its toxicological significance

, 2007
A 1H Nuclear Magnetic Resonance (NMR) spectroscopic investigation of the effects of single doses of four model hepatotoxins on male Sprague-Dawley rats showed that hypertyrosinemia was induced by three of the treatments (ethionine 300 mg/kg ...
Clayton, T. Andrew, Provost, Jean-Pierre, Everett, Jeremy, Nicholson, Jeremy K., Lindon, John C., Hanton, Gilles, Charuel, Claude, Le Net, Jean-Loic   +7 more
core   +1 more source

The photocatalytic destruction of the cyanotoxin, nodularin using TiO ₂ [PDF]

, 2005
Titanium dioxide (TiO2) photocatalysis has been used to initiate the destruction of nodularin, a natural hepatotoxin produced by cyanobacteria. The destruction process was monitored using liquid chromatography-mass spectrometry analysis which has also ...
Lawton, Linda A., Liu, Iain, Robertson, Peter K.J., Robertson, Peter K J; id_orcid, Bahnemann, Detlef W.   +4 more
core   +1 more source