Results 31 to 40 of about 3,849 (286)

Valproate (VPA)-Associated Hepatotoxicity

open access: yesPediatric Neurology Briefs, 1993
The metabolic pattern of VPA in 170 epileptic patients without symptoms or signs of hepatic side effects was compared to that in 11 patients with early symptoms and signs of hepatotoxicity and in 5 children with fulminant liver failure.
J Gordon Millichap
doaj   +1 more source

Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats

open access: yesBiochemistry and Biophysics Reports, 2023
Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats.
Olubisi E. Adeyi   +6 more
doaj   +1 more source

System-level metabolic effects of trematode infections in rodent models [PDF]

open access: yes, 2010
Background: Trematode infections impose a great burden on the developing world by impairing life quality, productivity and life span of an individual.
Saric, Jasmina
core   +1 more source

Cyanobacteria Characteristics and Methods for Isolation and Accurate Identification of Cyanotoxins: A Review Article [PDF]

open access: yesAvicenna Journal of Environmental Health Engineering, 2017
Cyanobacteria are bacteria found in different ecosystems, such as lakes and rocks. These bacteria, capable of photosynthesis, are important sources of oxygen.
Tengku Nadiah Yusof   +5 more
doaj   +1 more source

Level of natural hepatotoxin (indospicine) contamination in Australian camel meat [PDF]

open access: yes, 2016
Camel meat production for human consumption and pet food manufacture accounts for a relatively small part of overall red meat production in Australia. Reliable statistical data for the Australian production and consumption of camel meat are not available;
D'Arcy, Bruce R.   +3 more
core   +1 more source

Anti-oxidant protective effects of Cassia alata in rats exposed to carbon tetrachloride

open access: yesJournal of Applied Sciences and Environmental Management, 2006
The protective activity of Cassia alata against carbon tetrachloride (CCl4) – induced hepatotoxicity in rats was assessed. Crude extracts of petals of the plant in 0.5% ethanol were administered by intubation for 14 days prior to injection of 0.5ml Kg-1 ...
MO Wegwu, EO Ayalogu, OJ Sule
doaj   +1 more source

Metabolomic analysis indicates a pivotal role of the hepatotoxin microcystin in high light adaptation of Microcystis [PDF]

open access: yes, 2015
Microcystis is a freshwater cyanobacterium frequently forming nuisance blooms in the summer months. The genus belongs to the predominant producers of the potent hepatotoxin microcystin.
Sven Meissner   +8 more
core   +1 more source

The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma

open access: yesiScience, 2020
Summary: The PTEN gene is highly mutated in many cancers, including hepatocellular carcinoma. The PTEN protein is located at different subcellular regions—PTEN at the plasma membrane suppresses PI3-kinase signaling in cell growth, whereas PTEN in the ...
Takashi Kato   +6 more
doaj   +1 more source

Increasing Microcystis cell density enhances microcystin synthesis: a mesocosm study [PDF]

open access: yes, 2012
An experimental protocol using mesocosms was established to study the effect of Microcystis sp. cell abundance on microcystin production. The mesocosms (55 L) were set up in a shallow eutrophic lake and received either no (control), low (to simulate a ...
Dietrich, Daniel R   +7 more
core   +1 more source

Oxidative stress biomarkers in Clarias gariepinus (Burchel, 1822) exposed to Microcystin-LR

open access: yesBeni-Suef University Journal of Basic and Applied Sciences, 2017
Stress levels inflicted by microcystin-LR extracted from Microcystis aeruginosa were assessed by estimating the effects on the oxidative stress biomarkers in the liver, muscle and gill tissues of Clarias gariepinus. Microcystin-LR was administered to the
Patrick Omoregie Isibor
doaj   +1 more source

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