Results 21 to 30 of about 4,163 (290)

The Biosynthesis of Rare Homo-Amino Acid Containing Variants of Microcystin by a Benthic Cyanobacterium

open access: yesMarine Drugs, 2019
Microcystins are a family of chemically diverse hepatotoxins produced by distantly related cyanobacteria and are potent inhibitors of eukaryotic protein phosphatases 1 and 2A.
Tânia Keiko Shishido   +7 more
doaj   +1 more source

Canine Cyanotoxin Poisonings in the United States (1920s–2012): Review of Suspected and Confirmed Cases from Three Data Sources

open access: yesToxins, 2013
Cyanobacteria (also called blue-green algae) are ubiquitous in aquatic environments. Some species produce potent toxins that can sicken or kill people, domestic animals, and wildlife.
Tegwin K. Taylor   +4 more
doaj   +1 more source

1,1-Dichloroethylene: An Apoptotic Hepatotoxin? [PDF]

open access: yesEnvironmental Health Perspectives, 1984
Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial matrices.
E S, Reynolds   +3 more
openaire   +3 more sources

Ammonia as a neuro- and hepatotoxin: clinical aspects

open access: yesМедицинский совет, 2015
Ammonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as
A. O. Bueverov
doaj   +1 more source

p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol

open access: yesCell Death and Disease, 2022
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly aflatoxins.
Max J. Carlsson   +14 more
doaj   +1 more source

Hepatoprotective properties of new complex compound of germanium with a copper (medgerm) at experimental toxic hepatitis [PDF]

open access: yes, 2011
На моделі експериментального токсичного гепатиту встановлено, що профілактично-курсове застосування медгерму підвищує толерантність щурів до гепатотоксину та забезпечує більш сприятливий перебіг патологічного процесу, ніж референс-препарат.It is ...
Даниленко, А.І.   +3 more
core   +3 more sources

Valproate (VPA)-Associated Hepatotoxicity

open access: yesPediatric Neurology Briefs, 1993
The metabolic pattern of VPA in 170 epileptic patients without symptoms or signs of hepatic side effects was compared to that in 11 patients with early symptoms and signs of hepatotoxicity and in 5 children with fulminant liver failure.
J Gordon Millichap
doaj   +1 more source

Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats

open access: yesBiochemistry and Biophysics Reports, 2023
Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats.
Olubisi E. Adeyi   +6 more
doaj   +1 more source

Purification and Mechanism of Microcystinase MlrC for Catalyzing Linearized Cyanobacterial Hepatotoxins Using Sphingopyxis sp. USTB-05

open access: yesToxins, 2022
Cyanobacterial hepatotoxins, including microcystins (MCs) and nodularins (NODs), are widely produced, distributed and extremely hazardous to human beings and the environment.
Qianwen Zou   +9 more
doaj   +1 more source

Cyanobacteria Characteristics and Methods for Isolation and Accurate Identification of Cyanotoxins: A Review Article [PDF]

open access: yesAvicenna Journal of Environmental Health Engineering, 2017
Cyanobacteria are bacteria found in different ecosystems, such as lakes and rocks. These bacteria, capable of photosynthesis, are important sources of oxygen.
Tengku Nadiah Yusof   +5 more
doaj   +1 more source

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