Results 21 to 30 of about 6,799 (258)

Rapid and Highly Sensitive Non-Competitive Immunoassay for Specific Detection of Nodularin

open access: yesMicroorganisms, 2017
Nodularin (NOD) is a cyclic penta-peptide hepatotoxin mainly produced by Nodularia spumigena, reported from the brackish water bodies of various parts of the world.
Sultana Akter   +3 more
doaj   +1 more source

p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol

open access: yesCell Death and Disease, 2022
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly aflatoxins.
Max J. Carlsson   +14 more
doaj   +1 more source

In Vitro Mutagenic and Genotoxic Assessment of a Mixture of the Cyanotoxins Microcystin-LR and Cylindrospermopsin [PDF]

open access: yes, 2019
The co-occurrence of various cyanobacterial toxins can potentially induce toxic effects different than those observed for single cyanotoxins, as interaction phenomena cannot be discarded. Moreover, mixtures are a more probable exposure scenario. However,
Cameán Fernández, Ana María   +4 more
core   +1 more source

Ammonia as a neuro- and hepatotoxin: clinical aspects

open access: yesМедицинский совет, 2015
Ammonia is the most studied and, apparently, the most critical pathogenetic factor for hepatic encephalopathy (HE). The pathogenesis of PE is varied depending on the type of liver damage. Apart from neurotoxic properties, ammonia has general cytotoxic as
A. O. Bueverov
doaj   +1 more source

Studies of liver phosphorylase in hepatic injuries. I. Alteration in enzyme activity [PDF]

open access: yes, 1978
Phosphorylase activities (total and a form) were determined in the livers of experimental hepatic injuries with carbon tetrachloride or galactosamine and the livers of patients with liver diseases.
Kobayashi, Michio
core   +1 more source

Molecular detection of hepatotoxic cyanobacteria in inland water bodies of the Marmara Region, Turkey

open access: yesAdvances in Oceanography and Limnology, 2017
Blooms of cyanobacteria are an increasingly frequent phenomenon in freshwater ecosystems worldwide as a result of eutrophication. Many species can produce hepatotoxins that cause severe health hazards to humans.
Latife Köker   +3 more
doaj   +1 more source

Experimental models used for the study of antihepatotoxic agents

open access: yesJournal of Acute Disease, 2012
Both in vitro and in vivo liver models have been developed in the past years to study the hepatoprotective agents. These systems measure the ability of the test drug to prevent or cure liver toxicity (induced by various hepatotoxins) in experimental ...
Feroz Ahmad, Nahida Tabassum
doaj   +1 more source

Cloning and expression of first gene for biodegrading microcystins by Sphingopyxis sp. USTB-05 [PDF]

open access: yes, 2010
Harmful cyanobacterial blooms (HCBs) in natural waters are a growing environmental problem worldwide because microcystins (MCs) produced by cyanobacteria are potent hepatotoxins and tumor promoters. MCs are resistant against physical and chemical factors.
Hai Yan   +4 more
core   +2 more sources

Valproate (VPA)-Associated Hepatotoxicity

open access: yesPediatric Neurology Briefs, 1993
The metabolic pattern of VPA in 170 epileptic patients without symptoms or signs of hepatic side effects was compared to that in 11 patients with early symptoms and signs of hepatotoxicity and in 5 children with fulminant liver failure.
J Gordon Millichap
doaj   +1 more source

Syringic acid demonstrates better anti-apoptotic, anti-inflammatory and antioxidative effects than ascorbic acid via maintenance of the endogenous antioxidants and downregulation of pro-inflammatory and apoptotic markers in DMN-induced hepatotoxicity in rats

open access: yesBiochemistry and Biophysics Reports, 2023
Dimethyl nitrosamine (DMN) is a known hepatotoxin, carcinogen, and mutagen. This study is therefore carried out to investigate the therapeutic effects of syringic acid (SYRA) and ascorbic acid (ASCA) in DMN-induced hepatic injury in rats.
Olubisi E. Adeyi   +6 more
doaj   +1 more source

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