Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury
Cell Death Discovery, 2023 Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired survival pathways contribute to liver injury caused by hepatotoxins.
Katherine Byrnes +9 more
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The role of 2ʹ–5ʹ-oligoadenylate synthase-like protein (OASL1) in biliary and hepatotoxin-induced liver injury in mice [PDF]
Scientific ReportsFollowing an injury, the liver embarks on a process that drives the accumulation and reformation of the extracellular matrix, leading to hepatic fibrosis. Type I interferons (IFNs), including IFN-α and IFN-β, play a crucial role in averting chronic liver
Mwense Leya +7 more
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Acute liver injury is triggered by dysbiosis and microbial translocation involving gut–liver axis [PDF]
Gut MicrobesAcute liver injury (ALI) is a severe clinical condition that can progress to chronic liver failure, cirrhosis, or hepatocellular carcinoma, yet therapeutic options remain limited.
Urmi Halder +6 more
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A HepG2 Cell-Based Biosensor That Uses Stainless Steel Electrodes for Hepatotoxin Detection
Biosensors, 2022 Humans are frequently exposed to environmental hepatotoxins, which can lead to liver failure. Biosensors may be the best candidate for the detection of hepatotoxins because of their high sensitivity and specificity, convenience, time-saving, low cost ...
Amirhossein Pakseresht +2 more
exaly +3 more sources
Prostanoids in Liver Repair and Regeneration: Biosynthesis, Receptors, and Intercellular CommunicationSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyProstanoids typically refer to prostaglandins, prostacyclin, and thromboxane, and are a series of bioactive lipid mediators primarily derived from arachidonic acid. Prostanoids play pivotal roles in various physiological processes, including liver repair
Xinzhi Li +5 more
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Biosynthesis of Strontium Nanoparticles Using Mimosa pudica and its Antioxidant Effect [PDF]
Journal of Pharmacy and Bioallied SciencesA new area of nanotechnology, “green synthesis” studies nanomaterials utilizing natural biomaterials like plants, flowers, and microbesGreen nanoparticle synthesis offers various benefits, such as cost efficiency, pollution reduction, and environmental ...
Vallinayaki KN +2 more
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Transcriptional changes impact hepatic proteome in autophagy‐impaired liver [PDF]
FEBS Open BioHepatic proteomes are intricately controlled through biosynthesis, extracellular secretion, and intrahepatic degradation. Autophagy governs lysosome‐mediated intrahepatic degradation and the hepatic proteome.
Kamal Baral +13 more
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Toxins, 2013 A two and a half year old spayed female Miniature Australian Shepherd presented to a Montana veterinary clinic with acute onset of anorexia, vomiting and depression. Two days prior, the dog was exposed to an algal bloom in a community lake. Within h, the
Michael J. Murray +5 more
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Marine Drugs, 2019 Microcystins are cyclic heptapeptides from cyanobacteria that are potent inhibitors of protein phosphatases and are toxic to animals and humans. At present, more than 250 microcystin variants are known, with variants reported for all seven peptide ...
Vittoria Mallia +4 more
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Impaired liver regeneration and lipid homeostasis in CCl4 treated WDR13 deficient mice
Laboratory Animal Research, 2020 WDR13 - a WD repeat protein, is abundant in pancreas, liver, ovary and testis. Absence of this protein in mice has been seen to be associated with pancreatic β-cell proliferation, hyperinsulinemia and age dependent mild obesity.
Arun Prakash Mishra +4 more
doaj +1 more source