Results 51 to 60 of about 3,849 (286)
Advanced Science, EarlyView.This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha +5 more
wiley +1 more source
Advanced Science, EarlyView.Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang +10 more
wiley +1 more source
Early effects of the hepatotoxin, dimethylnitrosamine, on the control of protein synthesis initiation in liver [PDF]
, 1980 Following the administration of the hepatotoxin dimethyl nitrosamine (DMNA) to rats or mice, protein synthesis in the liver parenchymatous cells declines rapidly. The effect is due to a metabolic activation of the hepatotoxin in the endoplasmic membranes.
Nygård, Odd,
core
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
Advanced Science, EarlyView.An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng +17 more
wiley +1 more source
The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture
Acta Medica, 2006 D-galactosamine (GalN) is a highly selective hepatotoxin that causes liver damage similar to human viral hepatitis via depletion of uridine nucleotides, which subsequently diminishes synthesis of RNA and proteins. Model of galactosamine hepatotoxicity is
Otto Kučera +5 more
doaj +1 more source
Degradation of cyanobacterial hepatotoxins in batch experiments
Water Science and Technology, 2001 Bank filtration offers a cost effective and low maintenance technique for the removal of cyanobacterial hepatotoxins from drinking water. For bank filtration to be effective, the toxins must be degraded. The broad aim of this research was to determine whether the hepatotoxins, nodularin and microcystin-LR, could be completely removed from the soil ...
M J, Miller, H J, Fallowfield
openaire +2 more sources
Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal
Advanced Science, EarlyView.We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao +7 more
wiley +1 more source
Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy [PDF]
, 1995 Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and renal tubular epithelial cells. HGF is proteolytically activated in the tissue injured by hepatotoxin or nephrotoxin, suggesting that HGF functions as a crucial growth factor for ...
Miyazawa, Keiji +5 more
core +1 more source
A Screening Models of (In Vivo And In Vitro) Used for the Study of Hepatoprotective Agents [PDF]
, 2023 In order to evaluate hepatoprotective function, both in vitro and in vivo liver or hepatoprotective models have been constructed in the past. These methods examine a drug\u27s potential to prevent or minimize liver damage in test animals.
Samra, Samra +4 more
core +2 more sources