Results 71 to 80 of about 6,799 (258)

Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment

Annals of Hepatology, 2017
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepa-totoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF ...
Sunil Taneja, Pramod Kumar, Sahaj Rathi, Ajay Duseja, Virendra Singh, Radha Krishan Dhiman, Yogesh Kumar Chawla   +6 more
doaj   +1 more source

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog [PDF]

, 2009
Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear.
Asahina, Kinji, Deshaies, Raymond, Duan, Lewei, Dynnyk, Alla, Govindarajan, Sugantha, Lai, Michael M.-C., Liu, Helene Minyi, Machida, Keigo, Miyake, Kensuke, Mkrtchyan, Hasmik, Ou, Jing-hsiung James, Ray, Ratna, Seki, Ekihiro, Tsukamoto, Hidekazu   +13 more
core   +2 more sources

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

eLife, 2018
Reparative hepatocyte replication is impaired in chronic liver disease, contributing to disease progression; however, the underlying mechanism remains elusive.
Yi Xiong, Adriana Souza Torsoni, Feihua Wu, Hong Shen, Yan Liu, Xiao Zhong, Mark J Canet, Yatrik M Shah, M Bishr Omary, Yong Liu, Liangyou Rui   +10 more
doaj   +1 more source

Toxic Cyanobacteria Aerosols: Tests of Filters for Cells [PDF]

, 2015
Aerosolization of toxic cyanobacteria released from the surface of lakes is a new area of study that could uncover a previously unknown route of exposure to toxic cyanobacteria.
Haney, James F, Mack, Alexis, Murby, Amanda, Perry, Sean R   +3 more
core   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

REMOÇÃO DA HEPATOTOXINA (D-Leu1 )-MICROCISTINA-LR POR FILTROS DE REMOVAL OF HEPATOTOXIN (D-Leu1 )-MICROCISTIN-LR BY [PDF]

Revista DAE, 2009
As microcistinas (MCs) são toxinas produzidas por cianobactérias e representam um problema as companhias de água devido sua difícil remoção nos processos convencionais de tratamento de água.
Alessandro Minillo, William Deodato Isique, Heloiza Ferreira Alves do Prado, Douglas Antônio Alvaredo Paixão , Mauricio Rocha Dimitrov, Eliana Gertrudes de Macedo Lemos, Edson Pereira Tangerino   +6 more
doaj  

Mussels as Biomonitors of Lake Water Microcystin: A Final Report for the Summer 2000 Microcystin Monitoring Study [PDF]

, 2001
Mussel surveys performed in Baboosic, Depot, Little Squam, Squam, Lovell, North River, Northeast ...
Hathaway, Richard A., II
core   +2 more sources

Multimedia distributions, bioaccumulation, and trophic transfer of microcystins in the Geum River Estuary, Korea: Application of compound-specific isotope analysis of amino acids [PDF]

, 2019
To determine distributions, bioaccumulation, and trophic transfer of freshwater cyanobacterial toxins such as microcystins (MCs), surface water, suspended solids, sediments, and coastal organisms were collected from seven stations in inner and outer ...
신경훈
core   +1 more source

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti‐inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies

Animal Models and Experimental Medicine, EarlyView.
Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Fahmina Binty Azim Nova, Nazmul Hasan Eshaque, Md. Hossain Rasel, Zobayed Islam, Md. Mahmudul Hasan, Md. Liakot Ali, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +10 more
wiley   +1 more source