Results 71 to 80 of about 3,849 (286)

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

eLife, 2018
Reparative hepatocyte replication is impaired in chronic liver disease, contributing to disease progression; however, the underlying mechanism remains elusive.
Yi Xiong, Adriana Souza Torsoni, Feihua Wu, Hong Shen, Yan Liu, Xiao Zhong, Mark J Canet, Yatrik M Shah, M Bishr Omary, Yong Liu, Liangyou Rui   +10 more
doaj   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Evolution and detection of cyanobacterial hepatotoxin synthetase genes [PDF]

, 2007
Mass occurrences (blooms) of cyanobacteria are common in aquatic environments worldwide. These blooms are often toxic, due to the presence of hepatotoxins or neurotoxins. The most common cyanobacterial toxins are hepatotoxins: microcystins and nodularins.
Rantala, Anne
core  

REMOÇÃO DA HEPATOTOXINA (D-Leu1 )-MICROCISTINA-LR POR FILTROS DE REMOVAL OF HEPATOTOXIN (D-Leu1 )-MICROCISTIN-LR BY [PDF]

Revista DAE, 2009
As microcistinas (MCs) são toxinas produzidas por cianobactérias e representam um problema as companhias de água devido sua difícil remoção nos processos convencionais de tratamento de água.
Alessandro Minillo, William Deodato Isique, Heloiza Ferreira Alves do Prado, Douglas Antônio Alvaredo Paixão , Mauricio Rocha Dimitrov, Eliana Gertrudes de Macedo Lemos, Edson Pereira Tangerino   +6 more
doaj  

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug [PDF]

, 2020
: In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attempt to understand the differences in toxicological ...
Jonathan N Bauman, Ronald S Obach, Loretta M Cox, Amit S Kalgutkar, Kosea S Frederick, Aarti Sawant, Robert L Walsky   +6 more
core  

Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells

Toxins, 2019
Microcystin-LR is a cyclic heptapeptide hepatotoxin produced by harmful cyanobacteria. A panel of microRNAs containing miR-451a were found to be significantly changed in normal human liver cells HL7702 after exposure to microcystin-LR (MC-LR) in our ...
Lv Chen, Shu Yang, Cong Wen, Shuilin Zheng, Yue Yang, Xiangling Feng, Jihua Chen, Dan Luo, Ran Liu, Fei Yang   +9 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Hepatoprotective properties of new complex compound of germanium with a copper (medgerm) at experimental toxic hepatitis [PDF]

, 2011
На моделі експериментального токсичного гепатиту встановлено, що профілактично-курсове застосування медгерму підвищує толерантність щурів до гепатотоксину та забезпечує більш сприятливий перебіг патологічного процесу, ніж референс-препарат.It is ...
Даниленко, А.І., Тимчишин, О.Л., Годован, В.В., Кресюн, В.Й.   +3 more
core   +7 more sources

BLOOM OF PHYTOPLANKTONS IN ANZALI LAGOON AND IDENTIFICATION OF POISONOUS ALGAE

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2003
During the period of 1979-1980 in Abkenar and Hendkhaleh in Anzali lagoon, 67 I genus of phytoplanktons belong to 5 phylum were identified. The results showed that there is two peaks of phytoplankton blooms during a year (summer and, autumn) in which ...
P. Nijatkhah manavi1; Sh. Oryan2; A. Rostaeian2; R. Naghshine2; S.M. Fatemi
doaj