Results 111 to 120 of about 3,849 (286)

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

A novel microcystin-degrading bacterium, microbacterium sp. MA21 [PDF]

, 2013
A microcystin-degrading bacterium was isolated from Daechung reservoir, Korea. Theisolated bacterium was identified as Microbacterium sp. by 16S rRNA gene sequence analysis, anddesignated as Microbacterium sp. MA21.
So Ra Ko, Hee-Mock Oh, Chi-Yong Ahn, Y K Lee   +3 more
core   +1 more source

Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543

Frontiers in Microbiology, 2017
Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds.
Jouni Jokela, Lassi M. P. Heinilä, Tânia K. Shishido, Matti Wahlsten, David P. Fewer, Marli F. Fiore, Hao Wang, Esa Haapaniemi, Perttu Permi, Perttu Permi, Kaarina Sivonen   +10 more
doaj   +1 more source

Hepatotoxic slimming aids and other herbal hepatotoxins

Journal of Gastroenterology and Hepatology, 2008
AbstractPerceptions of safety and/or cultural mores prompt individuals to seek herbal slimming aids in preference to conventional dietary, physical activity and medication‐based protocols. In recent years, terpenoid‐containing dietary supplements have been implicated in causing severe and sometimes fatal hepatotoxicity.
Chitturi, Shivakumar, Farrell, Geoffrey
openaire   +3 more sources

Recombinant Human Thrombopoietin Reduces the Need for Platelet Transfusion in Patients With Chronic Liver Disease and Thrombocytopenia

American Journal of Hematology, EarlyView.
ABSTRACT Chronic liver disease (CLD)‐related thrombocytopenia can limit the feasibility of invasive procedures. Recombinant human thrombopoietin (rhTPO) has demonstrated a favorable safety profile without hepatotoxicity. We evaluated the efficacy and safety of rhTPO in patients with CLD‐related thrombocytopenia who were undergoing elective invasive ...
Yifan Han, Ning Lin, Jinghang Xu, Sikui Wang, Jinglan Jin, Jia Shang, Yongning Xin, Youwen Tan, Dazhi Zhang, Jinlin Hou, Ping An, Wen Xie, Yujuan Guan, Qingfang Xiong, Hong Wu, Huiguo Ding, Yu Chen, Rongkuan Li, Zhili Wen, Mingqin Lu, Jinhui Yang, Zhongyin Zhou, Yongjian Zhou, Zujiang Yu, Kecan Lin, Wei Wang, Yan Huang, Yuemin Nan, Xinhua Luo, Rongshu Shi, Yi Kang, Tao Han, Shiyan Chen, Kai Wang, Yunfeng Shan, Jiaping Li, Pingguo Liu, Zheng Lu, Jun Chen, Zhen Liu, Liaoyun Zhang, Li Yang, Jifang Sheng, Zhan Zeng, Yanyan Yu, Xiaoyuan Xu   +45 more
wiley   +1 more source

Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy

Mediators of Inflammation, 2015
TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and ...
David A. DeSantis, Chih-Wei Ko, Lan Wang, Peter Lee, Colleen M. Croniger   +4 more
doaj   +1 more source

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, EarlyView.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

Spectroscopic and In Silico Determination of the Structural and Antioxidant Properties of Essential Oils From Lavandula Species Cultivated in the Silivri Region of Istanbul

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plants are important sources of bioactive compounds that contribute to nutrition, health maintenance, and disease prevention. In this study, the chemical composition and antioxidant potential of essential oils obtained from Lavandula angustifolia “Sevtopolis” and Lavandula × intermedia cultivated in the Silivri region of Istanbul were ...
Bilge Bicak, Beray Kizilkaya, Serda Kecel Gunduz, Aliye Demet Demirag, Sabriye Percin Ozkorucuklu   +4 more
wiley   +1 more source

Development and Characterization of Ribes nigrum Extract‐Loaded PLGA/Chitosan Nanoparticles as a Vaginal Drug Delivery System for Vulvovaginal Candidiasis

Journal of Applied Polymer Science, EarlyView.
Ribes nigrum extract‐loaded PLGA/chitosan nanoparticles is developed as a vaginal drug delivery system for vulvovaginal candidiasis. The chitosan‐coated nanoparticles exhibit favorable physicochemical properties, strong mucoadhesion, sustained release for up to 2 weeks, excellent biocompatibility, and potent antifungal activity against Candida albicans,
Ayca Aslan Aras, Deniz Uygunoz, Emre Karaduman, Neslihan Merve Eren, Secil Gunay Avci, Mehmet Burcin Piskin, Emek Moroydor Derun   +6 more
wiley   +1 more source