Results 121 to 130 of about 6,799 (258)
Clinical Pharmacology &Therapeutics, EarlyView.Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries +8 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Busulfan's narrow therapeutic index and high pharmacokinetic (PK) variability warrant investigation of its exposure–toxicity relationship. We retrospectively analyzed 334 pediatric and young adult patients who underwent allogeneic hematopoietic stem cell transplantation at Seoul National University Children's Hospital between 2009 and 2020 and received
Sungyeun Bae +7 more
wiley +1 more source
New Zealand Guidelines for cyanobacteria in recreational fresh waters: Interim Guidelines [PDF]
, 2009 This document is divided into four main sections, plus 14 appendices. Section 1. Introduction provides an overview of the purpose and status of the document as well as advice on who should use it. Section 2.
Hamilton, David P. +4 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte +15 more
wiley +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Microcystins in components of twelve New Hampshire lakes of varied trophic status [PDF]
, 1999 Cyanobacteria toxins, called microcystins (MCs), were found in components of twelve, stratified New Hampshire (USA) lakes of varied trophic status during the summer of 1998.
Johnson, Kimberly M.
core +1 more source
, 2010 The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the
Cunha, Sergio S +2 more
core +1 more source
Food Chemistry International, EarlyView.After collecting Musa paradisiaca leaves, some were dried and others were used to produce aqueous extracts. The extracts and powders were characterized and then administered to rats made anaemic by PHZ. After 14 days of administration of the two samples, the rats were euthanized and it was observed that after 9 days of treatment, the aqueous extract ...
Josée Rebeca Nombo +8 more
wiley +1 more source
Occurrence and Distribution of Cyanobacteria and their Toxins in Silver Lake, New Hampshire [PDF]
, 2008 A study of Silver Lake, NH was performed as part of a 5-lake assessment of cyanobacteria prevalence and distribution. Multi-parameter fluorescence probe measurements of chlorophyll a and cyanobacteria concentrations (PC, phycocyanin fluorescence) were ...
Morison, Françoise
core +1 more source
Flavour and Fragrance Journal, EarlyView.Investigation of four medicinal plants of the family Myrtaceae. ABSTRACT Compounds derived from natural sources continue to serve as chemical scaffolds for designing prophylactic/therapeutic options for human healthcare. This study aimed to evaluate the phytochemical composition, antioxidant potential, in vitro anti‐inflammatory, antibacterial and ...
Archana Joshi +8 more
wiley +1 more source