Results 121 to 130 of about 34,396 (232)

Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis

Cell Proliferation, Volume 59, Issue 3, March 2026.
Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, Volume 293, Issue 6, Page 1587-1611, March 2026.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

What regulates hepcidin in poly-transfused β-Thalassemia Major: Erythroid drive or store drive?

Indian Journal of Pathology and Microbiology, 2014
Background: Hepcidin, a key regulator of iron homeostasis, is increased by iron overload and inflammation while suppressed by hypoxia. In spite of iron overload in β-Thalassemia Major (β-TM), a paradoxical decrease in hepcidin is observed. Aim: To assess
Richa Chauhan, Sunita Sharma, Jagdish Chandra   +2 more
doaj   +1 more source

Biochemical Responses to Experimentally Induced Short‐Term Low Energy Availability in Athletes: A Systematic Review

Scandinavian Journal of Medicine &Science in Sports, Volume 36, Issue 3, March 2026.
ABSTRACT Low energy availability (LEA) occurs when dietary energy intake is insufficient to meet the combined demands of exercise and essential physiological functions. Problematic LEA is recognized as the primary driver of Relative Energy Deficiency in Sport (RED‐S), but the short‐term physiological consequences of LEA remain less clearly defined ...
Isabel Guisado‐Cuadrado, Paula Recacha‐Ponce, Ana B. Peinado, Nuria Romero‐Parra   +3 more
wiley   +1 more source

Manipulation of the hepcidin pathway for therapeutic purposes

Haematologica, 2013
Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis. Abnormal hepcidin production has emerged as a causative factor in several common iron disorders.
Eileen Fung, Elizabeta Nemeth
doaj   +1 more source

Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron–sulphur cluster assembly pathways

The Journal of Physiology, Volume 604, Issue 5, Page 2229-2249, 1 March 2026.
Abstract figure legend Altered iron handling and mitochondrial pathways in FGR placentas. Placental tissue from FGR pregnancies showed increased expression of iron importers, transferrin and divalent metal transporter 1, and decreased expression of the iron exporter ferroportin, suggesting that the FGR placenta is retaining iron to meet its own ...
Veronica B. Botha, Heather C. Murray, Siddharth Acharya, Kirsty G. Pringle, Roger Smith, Joshua J. Fisher   +5 more
wiley   +1 more source

Reduced hepcidin level features osteoporosis

Experimental and Therapeutic Medicine, 2018
Osteoporosis (OP) is a common serious skeletal disorder marked by increased risk of bone fracture due to fragility. OP has been taken to be a disease linked with abnormal calcium metabolism that alone is obviously insufficient to explain the development of OP.
Liu, Bin, Liu, Caihua, Zhong, Weifeng, Song, Min, Du, Shouqin, Su, Jianli   +5 more
openaire   +3 more sources

Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson’s Disease

Parkinson's Disease, 2016
Background. Elevated brain iron levels have been implicated in the pathogenesis of Parkinson’s disease (PD). However, the precise mechanism underlying abnormal iron accumulation in PD is not clear.
Qi Xu, Anumantha G. Kanthasamy, Huajun Jin, Manju B. Reddy   +3 more
doaj   +1 more source

Rare autosomal dominant hereditary hemochromatosis associated with SLC40A1 gene: ferroportin disease or type 4 hereditary hemochromatosis? [PDF]

, 2019
Ferroportin (FPN1), encoded by the SLC40A1 gene, is the unique cellular iron exporter identified in mammals. FPN1 transfers iron from the intestine and macrophages into the bloodstream. This function is negatively regulated by hepcidin.
Faustino, Paula, Fleming, Rita, Lavinha, João, Machado, Miguel P., Mendonça, Joana, Simão, Rita, Tavares, Wilson, Vieira, Luís   +7 more
core  

Serum Hepcidin-25: A Predictor Of Response To Oral Iron Therapy.

Pakistan Journal of Medicine and Dentistry
Background: Discovery of hepcidin, and its receptor in year 2000 has revolutionized iron metabolism studies. Measurement of serum hepcidin, may supplement existing investigational parameters of iron status in anemias.
Ghazala Masood Farrukh, Adnan Zubairi, Amal Kamal, Syed Tauseef Ahmed   +3 more
doaj