Results 251 to 260 of about 117,801 (299)
Advanced Robotics Research, EarlyView.An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma +10 more
wiley +1 more source
Advanced Robotics Research, EarlyView.To achieve efficient cancer cell death, a bowl‐shaped PDA@UiO‐66@DOX nanorobot drug‐delivery nanoplatform was developed. Near‐infrared irradiation not only drives the nanorobot to exhibit self‐thermophoretic motion and elevates temperature but also triggers Doxorubicin (DOX) release via hyperthermia, enhancing cancer cells uptake of DOX and thereby ...
Tong Lin +6 more
wiley +1 more source
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British Journal of Surgery, 1997
Hereditary breast cancer is thought to account for less than 10 per cent of all breast cancers. Recently there have been significant advances in understanding of the genetics, with the sequencing of the genes BRCA1 and BRCA2 which are associated with hereditary breast cancer.Current understanding of hereditary breast cancer and its impact on the ...
A D, Hill +3 more
openaire +3 more sources
Hereditary breast cancer is thought to account for less than 10 per cent of all breast cancers. Recently there have been significant advances in understanding of the genetics, with the sequencing of the genes BRCA1 and BRCA2 which are associated with hereditary breast cancer.Current understanding of hereditary breast cancer and its impact on the ...
A D, Hill +3 more
openaire +3 more sources
Current Problems in Surgery, 2001
The clustering of breast cancers in family members has been known since Roman times. This observation has been given added clinical significance with the discovery of a family of breast cancer genes, BRCA1 and BRCA2. The BRCA1 gene is the first adult-onset cancer gene mapped to a single gene locus.
M E, Robson +3 more
openaire +2 more sources
The clustering of breast cancers in family members has been known since Roman times. This observation has been given added clinical significance with the discovery of a family of breast cancer genes, BRCA1 and BRCA2. The BRCA1 gene is the first adult-onset cancer gene mapped to a single gene locus.
M E, Robson +3 more
openaire +2 more sources
Hereditary Premenopausal Breast Cancer
Oncology Research and Treatment, 2002Less than 1% of breast cancers occur between the age of 20 and 30 years, but more than 50% of breast cancers under the age of 30 years are hereditary. Breast cancer mainly occurs sporadically, however, in 5 to maximally 10% of cases a genetic predisposition is present.
E-S, Strobel, E, Fritschka
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European Journal of Cancer Care, 1996
An overview is provided of the genetics of hereditary breast cancer, as well as the clinical aspects and the management of this disease. In September 1994 a new breast cancer gene, BRCA 2, was located and BRCA 1, discovered in 1990, was sequenced (Miki et al., 1994; Wooster et al., 1994). The implications of these discoveries are immense. Tests are now
openaire +2 more sources
An overview is provided of the genetics of hereditary breast cancer, as well as the clinical aspects and the management of this disease. In September 1994 a new breast cancer gene, BRCA 2, was located and BRCA 1, discovered in 1990, was sequenced (Miki et al., 1994; Wooster et al., 1994). The implications of these discoveries are immense. Tests are now
openaire +2 more sources
2017
Advances in next-generation sequencing have made panel testing an evolving tool when looking for mutations in others than the BRCA1/BRCA2 genes. However, the uncertainty about clinical utility and the possibility of unexpected results stresses the relevancy of appropriate pretest and post-test counselling by a knowledgeable genetics professional.
Teresa Ramón y Cajal +2 more
openaire +1 more source
Advances in next-generation sequencing have made panel testing an evolving tool when looking for mutations in others than the BRCA1/BRCA2 genes. However, the uncertainty about clinical utility and the possibility of unexpected results stresses the relevancy of appropriate pretest and post-test counselling by a knowledgeable genetics professional.
Teresa Ramón y Cajal +2 more
openaire +1 more source
Brca2 hereditary breast cancer pathophenotype
Breast Cancer Research and Treatment, 1997Four BRCA2 hereditary breast cancer (HBC) families manifested significant excesses of ‘tubular-lobular group’ (TLG) invasive carcinomas and lobular carcinoma in situ/atypical lobular hyperplasia in comparison to BRCA1-HBC cases.
J N, Marcus +7 more
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Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2009
Ten per cent of all breast cancer cases have a strong hereditary component in which half carry a deleterious mutation in the high penetrance genes BRCA1 or BRCA2. These genes confer a lifetime risk of 60-80% for breast cancer and 20-40% for ovarian cancer.
B, Schlehe, R, Schmutzler
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Ten per cent of all breast cancer cases have a strong hereditary component in which half carry a deleterious mutation in the high penetrance genes BRCA1 or BRCA2. These genes confer a lifetime risk of 60-80% for breast cancer and 20-40% for ovarian cancer.
B, Schlehe, R, Schmutzler
openaire +1 more source