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Update on hereditary breast cancer
Current Oncology Reports, 2006Women with BRCA1 or BRCA2 mutations are at substantial risk for breast and ovarian cancer. This review describes recent developments in the approach to hereditary breast cancer. Risk-reducing surgeries remain the most effective means of preventing breast cancer in mutation carriers.
Karen Lisa, Smith, Mark E, Robson
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Anticipation in hereditary breast cancer
Clinical Genetics, 2002To determine whether familial breast cancer occurs at a younger age in successive generations, we reviewed the clinical records of 435 Ashkenazi women with breast cancer referred to our cancer genetic clinic. Ninety‐eight who reported a maternal history of breast cancer were selected for further investigation. All women were genotyped for founder BRCA1/
E, Dagan, R, Gershoni-Baruch
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Hereditary predisposition to breast cancer
Current Opinion in Genetics & Development, 1996The breast cancer susceptibility gene on chromosome 17q, BRCA1, has now been isolated. Mutations in this gene have been detected in many families with a predisposition to breast cancer. Most of these mutations result in truncation and presumed inactivation of the BRCA1 protein.
M R, Stratton, R, Wooster
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Hereditary breast cancer: a review
Seminars in Cancer Biology, 2000Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. A positive family history of breast cancer is one of the strongest risk factors for the disease. In addition, many afflicted breast cancer families are characterized by early onset and bilateral tumors, and also, in some cases, associated malignancies ...
B, Arver +4 more
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Screening for Hereditary Breast Cancer
Seminars in Oncology, 2007Most women at risk for hereditary breast cancer opt for intensive breast screening rather than risk-reducing mastectomy. For this to be a rational choice, the vast majority of tumors must be detected either while still in situ or at a very early stage of invasion.
Rebecca, Dent, Ellen, Warner
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Hereditary breast cancer in Jews
Familial Cancer, 2004A family history of breast cancer poses higher risks for Jewish versus non-Jewish women, particularly for early-onset breast cancer. This appears to be due in large part to the high prevalence (2.5%) of three BRCA1 and BRCA2 founder mutations in Ashkenazi Jews. About 4 to 8% of non-Jewish male breast cancer cases versus 19% of Jewish male breast cancer
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Association of hereditary angioedema and hereditary breast cancer
Cancer Genetics and Cytogenetics, 1997A family is presented in whom hereditary angioedema (HAE) and hereditary breast cancer were coexistent, an association not previously reported. A potential for genetic and treatment-related interactions between the two conditions exists. The use of the hormonal agent danazol to suppress HAE is unlikely to adversely affect the development or outcome of ...
D R, Christie +3 more
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Praxis, 1996
Recently, genetic analyses in high risk families with several members suffering of breast and/or ovarian carcinoma led to the discovery of two genes, called BRCA1 and BRCA2, clearly responsible for hereditary predisposition of breast carcinoma. Another gene, p53, was also shown to be involved in hereditary predisposition of breast and other tumors in ...
L, Perey, D F, Schorderet
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Recently, genetic analyses in high risk families with several members suffering of breast and/or ovarian carcinoma led to the discovery of two genes, called BRCA1 and BRCA2, clearly responsible for hereditary predisposition of breast carcinoma. Another gene, p53, was also shown to be involved in hereditary predisposition of breast and other tumors in ...
L, Perey, D F, Schorderet
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Hereditary breast cancer and family cancer syndromes
World Journal of Surgery, 1994AbstractHereditary breast cancer (HBC) shows extant clinical and genetic heterogeneity. Clinically one finds the onset of breast cancer at an early age, an excess of bilaterality, and patterns of multiple primary cancer such as combinations of breast and ovarian carcinoma in the hereditary breast‐ovarian cancer (HBOC) syndrome. In addition to HBOC, one
H T, Lynch +7 more
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Treatment of Hereditary Breast Cancer
Seminars in Oncology, 2007Mutations in BRCA1 and BRCA2 are well-established causes of hereditary breast cancer. As genetic testing becomes more widespread, increasing numbers of women are known to have mutations at or shortly after their breast cancer diagnosis. Current evidence is insufficient to mandate different local or systemic treatment based upon the presence of a ...
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