Results 61 to 70 of about 117,801 (299)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Cancer Medicine, 2018 The prevalence of germ line mutations in non‐BRCA1/2 genes associated with hereditary breast cancer (BC) is low, and the role of some of these genes in BC predisposition and pathogenesis is conflicting.
Jan Hauke +44 more
doaj +1 more source
MEDICAL AND GENETIC COUNSELING OF HEREDITARY BREAST AND OVARIAN CANCER
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2018 Hereditary breast and ovarian cancer is one of the most common genetic pathology. Medical and genetic counseling of patients with hereditary breast and ovarian cancer and their families plays the important role in cancer care, as it helps to develop the ...
S. A. Laptiev +4 more
doaj +1 more source
Identification of the BRCA1 Gene Mutations in Exons 6, 13, and 20 in Patients with Breast Cancer, South Khorasan Province, Iran [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018 Introduction: Breast cancer is the most prevalent malignancy among females and the first leading cause of death from cancer in women. This highly heterogeneous disease is multifactorial. Mutations in BRCA1 and BRCA2 genes, which contribute to DNA repair,
Ghazaleh Khalili Tanha +3 more
doaj +1 more source
NGS Panels applied to Hereditary Cancer Syndromes [PDF]
, 2019 Cancer is among the leading causes of morbidity and mortality worldwide (Okur et al, 2017). Germline pathogenic variants for monogenic, highly penetrant cancer susceptibility genes are observed in 5%–10% of all cancers (Lu et al, 2014).
Gonçalves, João +4 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]
, 2018 Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core +1 more source
Disparities in Breast Cancer and African Ancestry: A Global Perspective [PDF]
, 2015 Recognition of breast cancer disparities between African‐American and White American women has generated exciting research opportunities investigating the biologic and hereditary factors that contribute to the observed outcome differences, leading to ...
Newman, Lisa A.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Functional consequence of the MET-T1010I polymorphism in breast cancer. [PDF]
, 2014 Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk.
Brown, Powel H +18 more
core +2 more sources