Results 41 to 50 of about 117,801 (299)

Laboratory assessment of the risks of malignant neoplasms of the mammary gland and ovaries

Репродуктивная эндокринология, 2018
In most cases, oncological diseases are hereditary: for breast cancer – 5–10%, and for ovarian cancer – 10–17%, and associated with the support of mutations in certain genes derived from one of the parents.
А. В. Шумицький, О. А. Бурка, І. В. Сідорова   +2 more
doaj   +1 more source

Healthcare Predictors of Information Dissemination About Genetic Risks

Cancer Control, 2022
Objectives Despite the benefits of genetic counseling and testing (GCT), utilization is particularly low among African American (AA) women who exhibit breast cancer features that are common in BRCA-associated cancer.
Vida Henderson PhD, PharmD, MPH, MFA, Shaila M. Strayhorn PhD, MPH, Nyahne Q. Bergeron MPH, Desmona C. Strahan MPH, Pamela S Ganschow MD, Aditya S. Khanna PhD, Karriem Watson DHSc, MS, MPH, Kent Hoskins MD, Yamile Molina PhD, MPH, MS   +8 more
doaj   +1 more source

Preventing hereditary cancers caused by opportunistic carcinogens [PDF]

, 2011
Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
core   +2 more sources

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

miRNA expression profiling of formalin-fixed paraffin-embedded (FFPE) hereditary breast tumors

Genomics Data, 2015
Hereditary breast cancer constitutes only 5–10% of all breast cancer cases and is characterized by strong family history of breast and/or other associated cancer types.
Miljana Tanić, Kira Yanowski, Eduardo Andrés, Gonzalo Gómez-López, María Rodríguez-Pinilla Socorro, David G. Pisano, Beatriz Martinez-Delgado, Javier Benítez   +7 more
doaj   +1 more source

Germline TP53 mutational spectrum in French Canadians with breast cancer [PDF]

, 2012
Background Specific germline mutations in the hereditary breast-ovarian cancer susceptibility (HBC/HBOC) genes, BRCA1, BRCA2 and PALB2, have been shown to recur in French Canadians of Quebec, Canada, and this has been attributed to common
Suzanna L Arcand, Mohammed R Akbari, Anne-Marie Mes-Masson, Diane Provencher, William D Foulkes, Steven A Narod, Patricia N Tonin   +6 more
core   +1 more source

Hereditary breast and ovarian cancer [PDF]

Hereditary Cancer in Clinical Practice, 2008
Familial breast cancer was first recognized in the Roman medical literature of 100 AD [1]. The first documentation of familial clustering of breast cancer in modern times was published by Broca, who reported 10 cases of breast cancer in 4 generations of his wife's family [2].
Gronwald Jacek, Byrski Tomasz, Huzarski Tomasz, Oszurek Oleg, Janicka Anna, Szymańska-Pasternak Jolanta, Górski Bohdan, Menkiszak Janusz, Rzepka-Górska Izabella, Lubiński Jan   +9 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Novel BRCA2 pathogenic variant c.5219 T > G; p.(Leu1740Ter) in a consanguineous Senegalese family with hereditary breast cancer

BMC Medical Genetics, 2019
Background Pathogenic variants associated with hereditary breast cancer have been reported for BRCA1 and BRCA2 (BRCA1/2) genes in patients from multiple ethnicities, but limited information is available from sub-Saharan African populations.
Jean Pascal Demba Diop, Rokhaya Ndiaye Diallo, Violaine Bourdon-Huguenin, Ahmadou Dem, Doudou Diouf, Mamadou Moustapha Dieng, Seydi Abdoul Ba, Yacouba Dia, Sidy Ka, Babacar Mbengue, Alassane Thiam, Oumar Faye, Papa Amadou Diop, Hagay Sobol, Alioune Dieye   +14 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source