Results 31 to 40 of about 117,801 (299)

Survival outcome in endometrial cancer patients according to hereditary predisposition

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: A familial history of ovarian cancer/breast cancer is considered a significant prognostic factor for ovarian cancer. We investigated hereditary factors by examining the incidence of synchronous malignancy in patients with endometrial cancer ...
Heon Jong Yoo, Myong Cheol Lim, Yedong Son, Sang-Soo Seo, Sokbom Kang, Sun Ho Kim, Chong Woo Yoo, Sang-Yoon Park   +7 more
doaj   +1 more source

NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]

, 2013
Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S, Kurzrock, Razelle, Schroeder, Rebecca Dunbar   +2 more
core   +3 more sources

Polymorphisms in Cancer Susceptibility Genes XRCC1, RAD51 and TP53 and the Risk of Breast Cancer in Serbian Women

The International Journal of Biological Markers, 2016
Background Thanks to immense improvements in technology over the past few decades, we have witnessed a major shift towards the idea that breast cancer results from a combined effect of multiple common alleles conferring low risk.
Ana M. Krivokuca PhD, Milena R. Cavic, Emina J. Malisic, Jelena D. Rakobradovic, Daniela Kolarevic-Ivankovic, Zorica I. Tomasevic, Mirjana V. Brankovic-Magic   +6 more
doaj   +1 more source

The withdrawal from oncogenetic counselling and testing for hereditary and familial breast and ovarian cancer. A descriptive study of an Italian sample [PDF]

, 2008
Background. Oncogenetic counselling is seldom followed through, even when individuals are eligible according to the test criteria. The basic variables which influence the decision to undergo the genetic counselling process are: risk perception, expected ...
Anita Caruso, Cristina Vigna, Gabriella Maggi, Fabio Massimo Sega, Francesco Cognetti, Antonella Savarese, JP Struewing, LG Bluman, C Lerman, KA Donovan, C Lerman, K Brain, JL Bottorff, I VanOostrom, M Bruno, K Glanz, KA Johnson, C Lerman, C Lerman, F Gil, K Kelly, AS Zigmond, M Costantini, DH Olson, C Galimberti, C Foster, MJ Esplen, R Kenen, DJ Bowen, D Braithwaite, SJ Durfy, AM Codori, C Lerman, IM Van Der Steenstraten, C Lerman, S Wiggins, C Lerman   +36 more
core   +2 more sources

Path Analysis of the Effect of Biological and Social Factors on the Case of Breast Cancer

Jurnal Info Kesehatan, 2019
Breast cancer is the number one cancer as the cause of death in women in developed and developing countries. Breast cancer has the highest case in women in 161 countries.
Nunik Ike Yunia Sari, Estin Gita Maringga, Wuri Widi Astuti   +2 more
doaj   +1 more source

Identification of a comprehensive spectrum of genetic factors for hereditary breast cancer in a Chinese population by next-generation sequencing. [PDF]

PLoS ONE, 2015
The genetic etiology of hereditary breast cancer has not been fully elucidated. Although germline mutations of high-penetrance genes such as BRCA1/2 are implicated in development of hereditary breast cancers, at least half of all breast cancer families ...
Xiaochen Yang, Jiong Wu, Jingsong Lu, Guangyu Liu, Genhong Di, Canming Chen, Yifeng Hou, Menghong Sun, Wentao Yang, Xiaojing Xu, Ying Zhao, Xin Hu, Daqiang Li, Zhigang Cao, Xiaoyan Zhou, Xiaoyan Huang, Zhebin Liu, Huan Chen, Yanzi Gu, Yayun Chi, Xia Yan, Qixia Han, Zhenzhou Shen, Zhimin Shao, Zhen Hu   +24 more
doaj   +1 more source

Germline copy number variations in BRCA1/2 negative families: Role in the molecular etiology of hereditary breast cancer in Tunisia.

PLoS ONE, 2021
Hereditary breast cancer accounts for 5-10% of all breast cancer cases. So far, known genetic risk factors account for only 50% of the breast cancer genetic component and almost a quarter of hereditary cases are carriers of pathogenic mutations in BRCA1 ...
Maroua Boujemaa, Yosr Hamdi, Nesrine Mejri, Lilia Romdhane, Kais Ghedira, Hanen Bouaziz, Houda El Benna, Soumaya Labidi, Hamza Dallali, Olfa Jaidane, Sonia Ben Nasr, Abderrazek Haddaoui, Khaled Rahal, Sonia Abdelhak, Hamouda Boussen, Mohamed Samir Boubaker   +15 more
doaj   +1 more source

Mutation screening of germline TP53 mutations in high-risk Chinese breast cancer patients

BMC Cancer, 2020
Background Germline TP53 mutations are associated with Li-Fraumeni syndrome, a severe and rare hereditary cancer syndrome. Despite the rarity of germline TP53 mutations, the clinical implication for mutation carriers and their families is significant ...
Ava Kwong, Vivian Yvonne Shin, Cecilia Y. S. Ho, Chun Hang Au, Thomas P. Slavin, Jeffrey N. Weitzel, Tsun-Leung Chan, Edmond S. K. Ma   +7 more
doaj   +1 more source

Pathology of hereditary breast cancer [PDF]

Modern Pathology, 2010
Patients with germline mutations in BRCA1 or BRCA2 genes are predisposed to breast cancer. The BRCA1-associated breast cancers have distinct morphology, being more often medullary-like, triple negative and showing a 'basal' phenotype. On the other hand, BRCA2 and BRCAX cancers are a heterogeneous group without a specific phenotype.
Da Silva, Leonard, Lakhani, Sunil R.
openaire   +3 more sources

Phenotype analysis of families with TP53 germline variants at the Center for Familial Breast and Ovarian Cancer, Cologne

Cancer Medicine
Purpose Tumor protein p53 (TP53) pathogenic variant (PV) carriers are identified during genetic testing for hereditary causes of cancer. PVs in TP53 are associated with the Li‐Fraumeni syndrome (LFS), and thus, surveillance and preventive measures are ...
K. Kast, K. Rhiem, M. Larsen, B. Wappenschmidt, R. Schmutzler   +4 more
doaj   +1 more source