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HEREDITARY BREAST CANCER

Сибирский онкологический журнал, 2016
Hereditary breast cancer occurs in 5–20 % of cases and it is associated with inherited mutations in particular genes, such as BRCA1 и BRCA2 in most cases.
E. M. Bit-Sava, N. B. Belogurova
doaj   +1 more source

Hereditary Breast Cancer [PDF]

Acta Oncologica, 1999
Information on genetics is in process of exponential growth, with a corresponding recognition that most medical information, screening and diagnostic tests, and disease processes have a genetic component. Hereditary breast cancer is a good example, showing the complexity of cancer genetics in a clinical context.
Brian P. Whooley, Patrick I. Borgen
openaire   +4 more sources

Hereditary Breast Cancer

Annual Review of Medicine, 1998
Genetic predisposition is responsible for 5–10% of all breast cancer, and a much larger percent of early-onset disease. Within the past few years, a number of genes associated with a high risk of breast cancer have been identified, including BRCA1, BRCA2, p53, and the Cowden disease gene PTEN/MMAC1. These genes appear to function as tumor suppressors,
L W, Ellisen, D A, Haber
  +6 more sources

Hereditary breast cancer

Russian Journal of Oncology, 2014
Ten million new cases of a cancer and more than 6,2 million death from diseases of this group are registered annually in the world. From 5 to 40% of malignant new growths of all anatomic localizations have a hereditary etiology, and this percent increases in connection with growth of the general incidence.
A. F Lazarev, N. S. Zadontseva, A. A. Gofman   +2 more
  +4 more sources

Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. [PDF]

, 2017
PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing.
Adams, Sophie B, Chan, Salina, Crawford, Beth, Gil, Elad, Leitner, Ofri, Ryan, Lauren, Sittler, Taylor, van 't Veer, Laura, van den Akker, Jeroen   +8 more
core   +1 more source

Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history

BMC Cancer, 2018
Background There is no international consensus up to which age women with a diagnosis of triple-negative breast cancer (TNBC) and no family history of breast or ovarian cancer should be offered genetic testing for germline BRCA1 and BRCA2 (gBRCA ...
Christoph Engel, Kerstin Rhiem, Eric Hahnen, Sibylle Loibl, Karsten E. Weber, Sabine Seiler, Silke Zachariae, Jan Hauke, Barbara Wappenschmidt, Anke Waha, Britta Blümcke, Marion Kiechle, Alfons Meindl, Dieter Niederacher, Claus R. Bartram, Dorothee Speiser, Brigitte Schlegelberger, Norbert Arnold, Peter Wieacker, Elena Leinert, Andrea Gehrig, Susanne Briest, Karin Kast, Olaf Riess, Günter Emons, Bernhard H. F. Weber, Jutta Engel, Rita K. Schmutzler, on behalf of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC)   +28 more
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Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer

Breast Cancer Research, 2019
Background The role of the BARD1 gene in breast cancer (BC) and ovarian cancer (OC) predisposition remains elusive, as published case-control investigations have revealed controversial results.
Nana Weber-Lassalle, Julika Borde, Konstantin Weber-Lassalle, Judit Horváth, Dieter Niederacher, Norbert Arnold, Silke Kaulfuß, Corinna Ernst, Victoria G. Paul, Ellen Honisch, Kristina Klaschik, Alexander E. Volk, Christian Kubisch, Steffen Rapp, Nadine Lichey, Janine Altmüller, Louisa Lepkes, Esther Pohl-Rescigno, Holger Thiele, Peter Nürnberg, Mirjam Larsen, Lisa Richters, Kerstin Rhiem, Barbara Wappenschmidt, Christoph Engel, Alfons Meindl, Rita K. Schmutzler, Eric Hahnen, Jan Hauke   +28 more
doaj   +1 more source

Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene. [PDF]

PLoS ONE, 2012
Aberrant miRNA expression has been previously established in breast cancer and has clinical relevance. However, no studies so far have defined miRNAs deregulated in hereditary breast tumors.
Miljana Tanic, Kira Yanowsky, Cristina Rodriguez-Antona, Raquel Andrés, Iván Márquez-Rodas, Ana Osorio, Javier Benitez, Beatriz Martinez-Delgado   +7 more
doaj   +1 more source

Germ line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients [PDF]

, 2000
Cataloged from PDF version of article.Germ line BRCA1 and/or BRCA2 mutations were screened in 50 Turkish breast and/or ovarian cancer patients composed of hereditary, familial, early onset and male cancer groups.
Icli, F., Muslumanoglu, M., Ozcelik, T., Ozdag, H., Ozturk, M., Sayek, I., Tarcan, O., Tez, M.   +7 more
core   +1 more source

Hereditary Breast Cancer [PDF]

, 2015
Kwong, A
core   +2 more sources