Results 21 to 30 of about 117,801 (299)

Feasibility of structured endurance training and Mediterranean diet in BRCA1 and BRCA2 mutation carriers – an interventional randomized controlled multicenter trial (LIBRE-1)

BMC Cancer, 2017
Background Women with pathogenic BRCA germline mutations have an increased risk for breast and ovarian cancer that seems to be modified by life-style factors.
Marion Kiechle, Ricarda Dukatz, Maryam Yahiaoui-Doktor, Anika Berling, Maryam Basrai, Vera Staiger, Uwe Niederberger, Nicole Marter, Jacqueline Lammert, Sabine Grill, Katharina Pfeifer, Kerstin Rhiem, Rita K. Schmutzler, Matthias Laudes, Michael Siniatchkin, Martin Halle, Stephan C. Bischoff, Christoph Engel   +17 more
doaj   +1 more source

Hereditary breast cancer

, 2021
The most important cause of developing hereditary breast cancer is germline? Two of the most common susceptibility genes are BRCA1 and BRCA2. Germline mutations in BRCA1 and BRCA2 genes are the main genetic and inherited factors for breast and ovarian cancer.
Minoru Miyashita, Takanori Ishida
openaire   +2 more sources

Hereditary Breast Cancer: Part I. Diagnosing Hereditary Breast Cancer Syndromes

The Breast Journal, 2008
Hereditary breast cancer (HBC) accounts for as much as 10% of the total BC burden. Most of these cases will be found to be due to a BRCA germline mutation. An estimated additional 15-20% of those affected with BC will have one or more first- and/or second-degree relatives with BC.
Henry T, Lynch, Edibaldo, Silva, Carrie, Snyder, Jane F, Lynch   +3 more
openaire   +2 more sources

Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)

Scientific Reports, 2022
Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality.
A. Berling-Ernst, M. Yahiaoui-Doktor, M. Kiechle, C. Engel, J. Lammert, S. Grill, R. Dukatz, K. Rhiem, F. T. Baumann, S. C. Bischoff, N. Erickson, T. Schmidt, U. Niederberger, M. Siniatchkin, M. Halle   +14 more
doaj   +1 more source

Hereditary Diffuse Gastric Cancer—Update Based on the Current Consort Recommendations

Current Oncology, 2022
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant inherited cancer syndrome that has been associated with a mutation of the CDH1, and rarely the CTNNA1 gene, respectively.
Christoph Treese, Britta Siegmund, Severin Daum   +2 more
doaj   +1 more source

Subjective versus objective risk in genetic counseling for hereditary breast and/or ovarian cancers [PDF]

, 2009
Background. Despite the fact that genetic counseling in oncology provides information regarding objective risks, it can be found a contrast between the subjective and objective risk.
Anita Caruso, Cristina Vigna, Bruna Marozzo, Fabio M Sega, Isabella Sperduti, Francesco Cognetti, Antonella Savarese, H Chaliki, RT Croyle, K Brain, C Lerman, KM Kash, M Watson, I Van Oostrom, AR Bradbury, G Rees, KJ Schlich-Bakker, K Kelly, KM Kelly, L D'Agincourt-Canning, MC Katapodi, MB Daly, FM Walter, JM Quillin, F Gil, A Caruso, DA Berry, G Parmigiani, M Federico, L Cortesi, A Caruso, A Caruso, C Lerman, D Ehus, DA Berry, TS Frank, FJ Couch, AS Zigmond, M Costantini, LG Bluman, J Cohen, JR Landis, C Foster, B Meiser, DG Evans, JT Heshka, C Condello, C Lerman   +47 more
core   +3 more sources

Clinical, Molecular and Geographical Features of Hereditary Breast/Ovarian Cancer in Latvia

Hereditary Cancer in Clinical Practice, 2005
Introduction The aim of the study is to evaluate the incidence and phenotype-genotype characteristics of hereditary breast and ovarian cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives ...
Gardovskis Andris, Irmejs Arvids, Miklasevics Edvins, Borosenko Viktors, Bitina Marianna, Melbarde-Gorkusa Inga, Vanags Andrejs, Kurzawski Grzegorz, Suchy Janina, Górski Bohdan, Gardovskis Janis   +10 more
doaj   +1 more source

Genetic anticipation is associated with telomere shortening in hereditary breast cancer. [PDF]

PLoS Genetics, 2011
There is increasing evidence suggesting that short telomeres and subsequent genomic instability contribute to malignant transformation. Telomere shortening has been described as a mechanism to explain genetic anticipation in dyskeratosis congenita and Li-
Beatriz Martinez-Delgado, Kira Yanowsky, Lucia Inglada-Perez, Lucia Inglada-Perez, Samuel Domingo, Miguel Urioste, Ana Osorio, Javier Benitez   +7 more
doaj   +1 more source

Training promotores to lead virtual hereditary breast cancer education sessions for Spanish-speaking individuals of Latin American heritage in California

BMC Women's Health, 2022
Background Awareness about hereditary breast cancer and the preventative steps to minimize disease risk is lower in Hispanic/Latina individuals than non-Hispanic White women in the United States.
Micaela Reyna, Rebeca Almeida, Alejandra Lopez-Macha, Shannon Fuller, Ysabel Duron, Laura Fejerman   +5 more
doaj   +1 more source

Optimizing the identification of risk-relevant mutations by multigene panel testing in selected hereditary breast/ovarian cancer families [PDF]

, 2017
The introduction of multigene panel testing for hereditary breast/ovarian cancer screening has greatly improved efficiency, speed, and costs. However, its clinical utility is still debated, mostly due to the lack of conclusive evidences on the impact of ...
Antoniou, Antoniou, Belardinilli, Bernstein, Broeks, Brown, Buffone, Capalbo, Capalbo, Castera, Chen, Coppa, Couch, Cybulski, Daly, Desmond, Easton, Economopoulou, Foulkes, Gad, Giannini, Giannini, Goldgar, Kurian, LaDuca, Li, Lincoln, Lindor, Neitzel, Nicolussi, Os, Plon, Prodosmo, Rebbeck, Renwick, Sandoval, Steffensen, Stratton, Telatar, Thompson, Thompson, Tung, Walsh, Walsh, Weischer, Williams   +45 more
core   +1 more source