Results 51 to 60 of about 16,165 (220)

Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome

Dermatology Research and Practice, 2010
Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS).
Michael C. Lynch, Bryan E. Anderson
doaj   +1 more source

Sebaceous gland tumors and internal malignancy in the context of Muir-Torre syndrome. A case report and review of the literature

World Journal of Surgical Oncology, 2006
Background The Muir-Torre syndrome is a rare autosomal dominant condition and is currently considered a subtype of the more common hereditary nonpolyposis colorectal cancer syndrome, in which multiple primary malignancies occur together with sebaceous ...
Tsachalis T, Vasiliadis K, Blouhos K, Tsalis K, Angelopoulos S, Betsis D   +5 more
doaj   +1 more source

Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation [PDF]

, 2018
Lynch syndrome is one of the most common hereditary colorectal cancer (CRC) syndrome and is caused by germline mutations of MLH1, MSH2 and more rarely MSH6, PMS2, MLH3 genes.
Benhattar, Jean, Bouzourene, Hanifa, Hutter, Pierre, Losi, Lorena, Martin, Patricia   +4 more
core  

Molecular testing for Lynch syndrome in people with colorectal cancer: systematic reviews and economic evaluation [PDF]

, 2017
This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Inherited mutations in deoxyribonucleic acid (DNA) mismatch repair (MMR) genes lead to an increased risk of colorectal cancer (CRC ...
Aarnio, Ahadova, Arends, Balmana, Barnetson, Barrow, Barrow, Barrow, Barzi, Boland, Bonadona, Bonis, Bouzourene, Bowel Cancer UK, Burn, Cairns, Caldes, Calvert, Cancer Research, Cancer Research UK, Cancer Research UK, Centre for Reviews and Dissemination, Chang, Chen, Colling, Commercial Medicines Unit, Curtis, Curtis, Cuzick, de Boer, Department of Health, Desouza, Dietmaier, Dineen, Dinh, Doble, Dolan, Domingo, Dove-Edwin, Drummond, East of Scotland Regional Genetic Service, Eccleston, Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group, Evers, Fajobi, Ferrandina, Finan, Frayling, Färkkilä, Gallego, Gallego, Gallego, Gavin, George, Giardiello, Goker, Goldstein, Great Britain, Grosse, Haanstra, Hall, Hampel, Hampel, Hanly, Haraldsdottir, Haraldsdottir, Havrilesky, Hendriks, Hildebrandt, Hornbrook, Hung, Ibrahim, Janus, Jenkins, John, Joint Formulary Committee, Järvinen, Järvinen, Kalady, Kaur, Kempers, Kloor, Kuppermann, Labianca, Ladabaum, Ladabaum, Le, Lewin, Ligtenberg, Lijmer, Limburg, Lin, Longworth, Loughrey, Lynch, Maeda, Mecklin, Mhaidat, Mittmann, Moher, Morak, Mueller, Mulder, Munoz, Mvundura, Møller, Møller, National Cancer Intelligence Network, National Cancer Intelligence Network, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, Ness, Newton, NHS, NHS Prescription Services, Niessen, Niv, Nout, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Office for National Statistics, Okkels, Overbeek, Overbeek, Palomaki, Pande, Parsons, Pawlik, Peninsula Technology Assessment Group (PenTAG), Philips, Pollett, Poulogiannis, Poynter, Ramsey, Ramsey, Ransohoff, Renkonen-Sinisalo, Sacco, Schmeler, Schnell, Senter, Severin, Sharp, Shia, Shlien, Sjursen, Sjursen, Slade, Snowsill, Snowsill, Southey, Stein, Sundar, The Stationery Office, Thompson, Thong, Trueman, UK Genetic Testing Network, Umar, US National Library of Medicine, Vasen, Vasen, Vasen, Vasen, Veysey, Wang, Ward, Webber, Welsh Cancer Intelligence and Surveillance Unit, Whiting, Whiting, Whiting, Wong, Wong, Wong, Zhang   +193 more
core   +2 more sources

Inaccuracy of Ureteroscopic Biopsy in Upper Tract Urothelial Carcinoma Can Lead to False Therapeutic Decisions: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Do not rely solely on negative endoscopic biopsies when diagnosing upper tract urothelial carcinoma (UTUC). Repeat ureteroscopy with biopsy if initial results are negative to reduce false negatives. Frozen section analysis (FSA) can provide rapid intraoperative confirmation and guide treatment decisions.
Ayoub Hidayat‐Allah, Frank Friedersdorff   +1 more
wiley   +1 more source

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2021
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various ...
Mohammad Hassan Jokar, Sima Sedighi, Maliheh Moradzadeh   +2 more
doaj  

MT1XT20 single quasi-monomorphic mononucleotide marker for detection of microsatellite instability in iranian patients with hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]

, 2016
Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary or sporadic, demonstrate better prognosis, altered response to fluorouracil (5FU) chemotherapy and altered operative approach.
Emami, Mohammad Hassan., Farahani, Najmeh., Hashemzadeh-Chaleshtori, Morteza., Nikpour, Parvaneh., Salehi, Rasoul., Zeinalian, Mehrdad.   +5 more
core  

A rare case of colonic adenocarcinoma in a pediatric patient

JPGN Reports, Volume 6, Issue 4, Page 400-403, November 2025.
Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Christine Kaba, Kelsey Chatman, Nicole Hames, Jose E. Velazquez Vega, Hillary Bashaw   +4 more
wiley   +1 more source

Assessing pathogenicity of MLH1 variants by co-expression of human MLH1 and PMS2genes in yeast [PDF]

, 2009
Background Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the hMLH1 gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC).
Matjaz Vogelsang, Aleksandra Comino, Neja Zupanec, Petra Hudler, Radovan Komel, B Vogelstein, LA Loeb, M Nystrom-Lahti, J Jiricny, JE Clodfelter, L Belvederesi, E Kondo, M Mac Partlin, TE Raevaara, AR Ellison, M Takahashi, J Trojan, H Shimodaira, K Drotschmann, PV Shcherbakova, A Brieger, RJ Rothstein, F Storici, M Strand, R Parsons, RD Gietz, A Wach, P Polaczek, RD Gietz, DE Lea, A Nicholson, MA Caligo, C Ishioka, S Yamane, P Hudler, IP Tomlinson, Y Hendriks, B Quaresima, J Raedle, JM Buerstedde, R Ward, B Liu, B Dieumegard, P Plevova, J Plaschke, Z Yuan, S Guerrette, M Genuardi, M Cravo, BM Rossi, M Scartozzi, H Nakagawa   +51 more
core   +2 more sources

Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin

International Journal of Cancer, Volume 157, Issue 7, Page 1481-1495, 1 October 2025.
What's New? Integrins are critical mediators of cell adhesion and migration and have been implicated in cancer progression. Here, the authors show that endothelial cells in target organs of colorectal cancer metastasis express fibronectin, and that colorectal cancer tumour cells can bind fibronectin through integrin β6. This interaction is resistant to
Chiara Van Passen, Julia Krug, Luisa Weiß, Mariam Mohamed Abdou, Philipp Tripal, Benjamin Schmid, René Krüger, Yanmin Lyu, Bisan Abdalfatah Zohud, Katja Petter, Carol Geppert, Susanne Merkel, Barbara Bärthlein, Philipp Busenhart, Michael Scharl, Elisabeth Naschberger, Michael Stürzl   +16 more
wiley   +1 more source