Results 41 to 50 of about 9,611 (131)

Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes.
Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Tainus Ali, Sajjad Karim, Loubna Siraj Mira, Fahd Al‐Abbasi, Murad Aljiffry, Mohammed Ghunaim, Abdulrahman Sibiany, Peter Natesan Pushparaj   +10 more
wiley   +1 more source

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 895-913, March 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain, Sana Qammar, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Patient‐Reported‐Outcome‐Measures (PROMs) After Gastrointestinal Endoscopic Resections

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background Data on patient‐reported outcome measures (PROMs) of patients undergoing endoscopic resections have been sparse. The aim of our study was the prospective assessment of the Gastrointestinal Quality of Life Index (GIQLI) as a baseline and post‐endoscopic resection (ER) measurement in patients with epithelial mucosal neoplasms ...
Laura Retzbach, Karl‐Hermann Fuchs, Markus Brand, Thomas J. Lux, Alexander Meining   +4 more
wiley   +1 more source

Algunos aspectos genéticos, moleculares y clínicos del cáncer colorrectal hereditario no polipoideo Some genetic, molecular and clinical aspects of nonpolyposis hereditary colorectal cancer

Revista Cubana de Investigaciones Biomédicas, 2004
Se hizo una revisión con el objetivo de profundizar en el conocimiento del cáncer colorrectal hereditario no polipoideo; resaltando su evolución histórica, así como sus características genéticas, moleculares y clínicas que condicionan el manejo clínico ...
Silvia Gra Menéndez, Diana Cruz-Bustillo Clarens   +1 more
doaj  

HEREDITARY NON-POLYPOSIS COLORECTAL CANCER (LYNCH SYNDROME) PADA WANITA UMUR 16 TAHUN

Majalah Kedokteran Andalas, 2011
AbstrakKanker kolorektal menduduki peringkat ketiga jenis kanker yang paling sering terjadi di dunia. Sekitar 3% kasus kanker kolorektal merupakan jenis hereditary non polyposis colorectal cancer (HNPCC)/Lynch syndrome, yang sering muncul pada usia muda.
Asril Zahari, Sudiyatmo Sudiyatmo
doaj   +1 more source

Colorectal Adenocarcinoma: A Comprehensive Narrative Review of Molecular Pathogenesis, Metabolic Vulnerabilities, and Therapeutic Potential of Sorghum Polyphenols

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Colorectal cancer (CRC) remains a formidable global health challenge, characterized by uncontrolled cell proliferation and significant socioeconomic burden. Projections anticipate a substantial increase in new cases, straining healthcare systems worldwide.
Birhanemaskal Malkamu, Maria Beatrice Morelli   +1 more
wiley   +1 more source

DNA Mismatch Repair in Eukaryotes and Bacteria

Journal of Nucleic Acids, 2010
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human ...
Kenji Fukui
doaj   +1 more source

Malignant phyllodes tumor in Lynch syndrome: a case report

Journal of Medical Case Reports, 2019
Background Lynch syndrome, or hereditary nonpolyposis colorectal cancer, is an autosomal dominant genetic syndrome that predisposes individuals to multiple cancer types.
Shayma Kazmi, Steven Wagner, Rebecca Heintzelman, Melanie Corbman   +3 more
doaj   +1 more source

Urothelial carcinoma: Perioperative considerations from top to bottom

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 528-551, November/December 2025.
Abstract Urothelial carcinoma is an aggressive entity that is associated with significant morbidity, but there have been major advances in both our understanding of and treatment options for patients with this disease. In this review, the authors focus on novel therapeutic and diagnostic approaches in the perioperative setting, with an emphasis on ...
Wesley Yip, Salvador Jaime‐Casas, Anjaney Kothari, Mary Sullivan, Leslie K. Ballas, Domenique Escobar, Anne K. Schuckman, Jonathan E. Rosenberg, Jonathan A. Coleman   +8 more
wiley   +1 more source

The Quality of Life of Patients with Hereditary Nonpolyposis Colorectal Cancer Undergoing Preoperative Chemoradiation

Applied Sciences, 2020
Of all the neoplastic sites, colorectal cancer (CRC) is one of the most common cancers in the family. Studies estimate that approximately 30% of all the CRC cases are a hereditary form of the disease with a potentially high impact on the quality of life (
Valeriu Aurelian Chirica, Mioara Matei, Roxana Postolica, Liliana Chelaru, Irina Mihaela Esanu, Lidia Sanduleac, Vlad Porumb, Mihaela Boanca, Elena Adorata Coman, Doina Azoicai   +9 more
doaj   +1 more source