Results 41 to 50 of about 16,258 (219)

N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]

, 2006
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Brieger, Angela, Plotz, Guido, Raedle, Jochen, Trojan, Jörg, Zeuzem, Stefan   +4 more
core  

Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome. [PDF]

, 2008
Individuals with Lynch syndrome are predisposed to cancer due to an inherited DNA mismatch repair gene mutation. However, there is significant variability observed in disease expression likely due to the influence of other environmental, lifestyle, or ...
Amos, Christopher I, Broaddus, Russell, Chen, Jinyun, Frazier, Marsha L, Lynch, Patrick M, Osterwisch, Daniel R, Pande, Mala   +6 more
core   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

Hereditary Colorectal Cancer in China

Hereditary Cancer in Clinical Practice, 2005
The purpose of this article is to review basic research as well as clinical studies on Chinese hereditary colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) accounts for 2.2% of all colorectal cancer, and Chinese ...
Shu Zheng, Yanqin Huang, Ying Yuan
doaj   +1 more source

Investigating the Link between Lynch Syndrome and Breast Cancer

European Journal of Breast Health, 2020
Objective:Lynch syndrome is an inherited genetic disorder associated with a predisposition to early-onset colorectal and endometrial cancers, but breast cancer risk in these patients is debated. The aim of this study is to evaluate breast cancer rates in
Megan Sheehan, Brandie Heald, Courtney Yanda, Erinn Downs Kelly, Stephen Grobmyer, Charis Eng, Matthew Kalady, Holly Pederson   +7 more
doaj   +1 more source

Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation [PDF]

, 2018
Lynch syndrome is one of the most common hereditary colorectal cancer (CRC) syndrome and is caused by germline mutations of MLH1, MSH2 and more rarely MSH6, PMS2, MLH3 genes.
Benhattar, Jean, Bouzourene, Hanifa, Hutter, Pierre, Losi, Lorena, Martin, Patricia   +4 more
core  

Bacterial Infections Role in Gynecological Cancers Development: Narrative Review

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Gynecological cancers are among the most common cancers in women that affect female reproductive organs. The most common gynecological cancers are ovarian, cervical, uterine/endometrial, vaginal, and vulvar cancer. Women's reproductive organs have a dynamic and relative microbial balance.
Robab Azargun, Maryam Azargoon, Zahra Asefy, Mina Yekani, Vahideh Tarhriz, Fatemeh Yeganeh, Mohammad Yousef Memar, Shirin Eyvazi   +7 more
wiley   +1 more source

MT1XT20 single quasi-monomorphic mononucleotide marker for detection of microsatellite instability in iranian patients with hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]

, 2016
Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary or sporadic, demonstrate better prognosis, altered response to fluorouracil (5FU) chemotherapy and altered operative approach.
Emami, Mohammad Hassan., Farahani, Najmeh., Hashemzadeh-Chaleshtori, Morteza., Nikpour, Parvaneh., Salehi, Rasoul., Zeinalian, Mehrdad.   +5 more
core  

Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes.
Mahmood Rasool, Absarul Haque, Mohammed Alharthi, Tainus Ali, Sajjad Karim, Loubna Siraj Mira, Fahd Al‐Abbasi, Murad Aljiffry, Mohammed Ghunaim, Abdulrahman Sibiany, Peter Natesan Pushparaj   +10 more
wiley   +1 more source

Analysis of extended genomic rearrangements in oncological research. [PDF]

, 2007
Screening for genomic rearrangements is a fundamental task in the genetic diagnosis of many inherited disorders including cancer-predisposing syndromes.
ACETO GM, CAMA A., COLUCCI G, CURIA MC, DE LELLIS L, MARIANI COSTANTINI R, RUSSO, Antonio, TORACCHIO S   +7 more
core   +1 more source