Results 51 to 60 of about 9,611 (131)

Risk of colorectal cancer by family history of both colorectal carcinomas and colorectal polyps: a nationwide cohort study

Cancer Communications, Volume 45, Issue 11, Page 1407-1416, November 2025.
Abstract Background The increased risk of colorectal cancer (CRC) associated with family history of both colorectal in situ or invasive carcinomas (Stage 0 to IV) and colorectal polyps is attributed solely to family history of CRC, resulting in an underestimation of the actual risk. We aimed to assess the association between overall and early‐onset CRC
Yuqing Hu, Elham Kharazmi, Qunfeng Liang, Hermann Brenner, Jan Sundquist, Kristina Sundquist, Mahdi Fallah   +6 more
wiley   +1 more source

Inaccuracy of Ureteroscopic Biopsy in Upper Tract Urothelial Carcinoma Can Lead to False Therapeutic Decisions: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Do not rely solely on negative endoscopic biopsies when diagnosing upper tract urothelial carcinoma (UTUC). Repeat ureteroscopy with biopsy if initial results are negative to reduce false negatives. Frozen section analysis (FSA) can provide rapid intraoperative confirmation and guide treatment decisions.
Ayoub Hidayat‐Allah, Frank Friedersdorff   +1 more
wiley   +1 more source

A rare case of colonic adenocarcinoma in a pediatric patient

JPGN Reports, Volume 6, Issue 4, Page 400-403, November 2025.
Abstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Christine Kaba, Kelsey Chatman, Nicole Hames, Jose E. Velazquez Vega, Hillary Bashaw   +4 more
wiley   +1 more source

Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels

BMC Medical Genetics, 2009
Background Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality.
Bendahl Pär-Ola, Carlsson Christina, Domanska Katarina, Nilbert Mef   +3 more
doaj   +1 more source

Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin

International Journal of Cancer, Volume 157, Issue 7, Page 1481-1495, 1 October 2025.
What's New? Integrins are critical mediators of cell adhesion and migration and have been implicated in cancer progression. Here, the authors show that endothelial cells in target organs of colorectal cancer metastasis express fibronectin, and that colorectal cancer tumour cells can bind fibronectin through integrin β6. This interaction is resistant to
Chiara Van Passen, Julia Krug, Luisa Weiß, Mariam Mohamed Abdou, Philipp Tripal, Benjamin Schmid, René Krüger, Yanmin Lyu, Bisan Abdalfatah Zohud, Katja Petter, Carol Geppert, Susanne Merkel, Barbara Bärthlein, Philipp Busenhart, Michael Scharl, Elisabeth Naschberger, Michael Stürzl   +16 more
wiley   +1 more source

Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average‐Risk Women

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Objective The gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case–control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi‐center Colorectal Neoplasia Screening with ...
Doratha A. Byrd, Maria F. Gomez, Stephanie R. Hogue, Jessica R. Burns, Nate Smith, Joshua Sampson, Erikka Loftfield, Patricia G. Wolf, Yunhu Wan, Andrew Warner, Belynda Hicks, Casey Dagnall, Kristine Jones, Youngchul Kim, Jin Xu, Jianxin Shi, Rashmi Sinha, Emily Vogtmann   +17 more
wiley   +1 more source

The genetic basis of Lynch syndrome and its implications for clinical practice and risk management

The Application of Clinical Genetics, 2014
Stephanie A Cohen,1 Anna Leininger2 1Cancer Genetics Risk Assessment Program, St Vincent Health, Indianapolis, IN, USA; 2Minnesota Oncology, Woodbury, MN, USA Abstract: Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for
Cohen SA, Leininger A
doaj  

Quality of Life in Adult Individuals Living With or at Risk of a Hereditary Cancer Predisposition Syndrome: A Scoping Review of the Qualitative Literature

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background The in‐depth understanding of the impact of a hereditary cancer predisposition syndrome (HCPS) on the health‐related quality of life (HRQOL) of individuals with a hereditary cancer burden contributes to the improvement of counselling strategies as well as care planning and informs the development of patient‐reported outcome measures
M. Sztankay, S. Wheelwright, V. Vassiliou, E. M. A. Bleiker, B. Rahman, B. Holzner, A. Yener, V. Engele, A. S. Oberguggenberger, EORTC Quality of Life Group   +9 more
wiley   +1 more source

Detección de mutaciones de los genes hMLH1 y hMSH2 del sistema de reparación de malos apareamientos del ADN en familias colombianas sospechosas de cancer colorrectal no polipósico hereditario (síndrome de Lynch).

Biomédica: revista del Instituto Nacional de Salud, 2005
Introducción. El cáncer colorrectal es la segunda causa de morbilidad y mortalidad por cáncer en los países desarrollados. En Colombia es la quinta causa de muerte entre los diferentes cánceres.
Andrea Gómez, Gustavo Salguero, Herbert García, Fabio Aristizábal, Oscar Gutiérrez, Luis Alberto Angel, Jorge Padrón, Carlos Martínez, Humberto Martínez, Omar Malaver, Rosa Barvo, Alejandro Giraldo   +11 more
doaj   +1 more source

Narrative review comparing the epidemiology, characteristics, and survival in sporadic colorectal carcinoma/Lynch syndrome

Journal of Coloproctology, 2020
Introduction: Colorectal carcinoma is the third most prevalent neoplasm in the world, and the second cause of death by cancer. The most part of these neoplasms are sporadic by somatic mutations, but around 15% are hereditary, such as Lynch syndrome or ...
Maria Beatriz de Matos, Laura Elisabete Barbosa, João Paulo Teixeira   +2 more
doaj   +1 more source