Results 31 to 40 of about 16,258 (219)

A comprehensive custom panel evaluation for routine hereditary cancer testing: improving the yield of germline mutation detection

Journal of Translational Medicine, 2020
Background In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management.
Carolina Velázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante, Mercedes Durán   +9 more
doaj   +1 more source

Lynch Syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old. [PDF]

, 2014
BACKGROUND: In clinical practice, unexpected diagnosis of colorectal cancer in young patients requires prompt surgery, thus genetic testing for Lynch Syndrome is frequently missed, and clinical management may result incorrect.
Baiocchi GL, Baronchelli C, Gheza F, Giulini SM., Marchina E, Portolani N, Scaglia A, Tiberio GA, Vermi W, Zogno C   +9 more
core   +1 more source

Role of APC and DNA mismatch repair genes in the development of colorectal cancers

Molecular Cancer, 2003
Colorectal cancer is the third most common cause of cancer-related death in both men and women in the western hemisphere. According to the American Cancer Society, an estimated 105,500 new cases of colon cancer with 57,100 deaths will occur in the U.S ...
Roy Deodutta, Narayan Satya
doaj   +1 more source

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source

Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. [PDF]

PLoS ONE, 2013
Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.We
Mev Dominguez-Valentin, Christina Therkildsen, Srinivas Veerla, Mats Jönsson, Inge Bernstein, Ake Borg, Mef Nilbert   +6 more
doaj   +1 more source

Primary retroperitoneal nodal endometrioid carcinoma associated with Lynch syndrome: A case report

Frontiers in Oncology, 2023
We report a rare case of primary nodal, poorly differentiated endometrioid carcinoma associated with Lynch syndrome. A 29-year-old female patient was referred by her general gynecologist for further imaging with suspected right-sided ovarian endometrioid
Daniela Fischerova, Umberto Scovazzi, Natacha Sousa, Tatevik Hovhannisyan, Andrea Burgetova, Pavel Dundr, Kristýna Němejcová, Rosalie Bennett, Michal Vočka, Filip Frühauf, Roman Kocian, Tereza Indrielle-Kelly, David Cibula   +12 more
doaj   +1 more source

Colorectal Cancer in the Family: Psychosocial Distress and Social Issues in the Years Following Genetic Counselling [PDF]

, 2007
Background This study examined: (1) levels of cancer-specific distress more than one year after genetic counselling for hereditary nonpolyposis colorectal cancer (HNPCC); (2) associations between sociodemographic, clinical and psychosocial factors and ...
Bleiker Eveline MA, Menko Fred H, Kluijt Irma, Taal Babs G, Gerritsma Miranda A, Wever Lidwina DV, Aaronson Neil K   +6 more
core   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Mouse models of colorectal cancer. [PDF]

, 2011
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip, Tong, Yunguang, Yang, Wancai   +2 more
core   +2 more sources

A Review on Image Processing and Fractal Analysis in Oral Potentially Malignant Disorders

Oral Diseases, EarlyView.
ABSTRACT Aim The clinical evaluation of patients with oral potentially malignant disorders is primarily based on physical examination and observable clinical features. Clinical photographs play a key role in patient monitoring and help identify signs that may indicate malignant transformation.
André Goulart Poletto, Flaviana Silva de Souza, Lilian Bezerra, Thiago Pires Claudio, Jesse Parente Tocantins, Helena Miguel Cotter, Riéli Elis Schulz, Karin Berria Tomazelli, Elena Riet Correa Rivero, Fabio Luiz Coracin, Gustavo Davi Rabelo   +10 more
wiley   +1 more source