Results 11 to 20 of about 9,611 (131)

A Rare Case of Seminoma in an Elderly Patient With Suspected Lynch Syndrome. [PDF]

Clin Case Rep
ABSTRACT Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer, is caused by mutations in the mismatch repair genes and confers genetic predisposition to colorectal and other cancers. Germ cell tumors, the majority of which are seminomas, usually arise sporadically and predominantly occur in younger patients; their association ...
Kamandi M, Boozari M, Soltani E, Soltani S.   +3 more
europepmc   +2 more sources

Hereditary nonpolyposis colorectal cancer and familial colorectal cancer in Central part of Iran, Isfahan

Journal of Research in Medical Sciences, 2012
Background: There is a lack of data on familial aggregation of colorectal cancer (CRC) in Iran. We aimed to deter-mine the frequency of hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) and to determine the frequency ...
Amin Nemati, Zahra Kazemi Rahmatabadi, Alimohammad Fatemi, Mohammad Hassan Emami   +3 more
doaj   +1 more source

Syndrome in question [PDF]

Anais Brasileiros de Dermatologia, 2015
Muir-Torre syndrome is a rare genodermatosis characterized by the occurrence of at least one sebaceous tumor associated with visceral neoplasia, but with no predisposing factors.
Catharina Maria Freire de Lucena Pousa, Fernanda Guedes Lavorato, Fernanda Valente Rehfeldt, Danielle Mann, Maria de Fátima Gonçalves Scotelaro Alves   +4 more
doaj   +1 more source

Advanced Colon Cancer Before the Age of 20 Years: A Case for Extension of the Current Colonscopy Surveillance Guidelines in Hereditary Nonpolyposis Colorectal Cancer Syndrome

Canadian Journal of Gastroenterology, 2004
BACKGROUND: Hereditary nonpolyposis colorectal cancer (HNPCC) currently accounts for between 2% to 6% of all colorectal adenocarcinomas. Controversies exist regarding the current guidelines for colonoscopic screening for colon cancer.
Victor K Wong, Eric M Yoshida, Anthony G Ryan, Stephen GF Ho, Baljinder Salh   +4 more
doaj   +1 more source

High Grade Dysplastic Rectal Adenoma in a Young Patient With Café-Au-Lait Spots: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Colorectal cancer screening guidelines typically focus on familial history and age‐related risk factors, yet Café‐au‐lait macules could serve as early indicators for tailored surveillance protocols. This case underscores the importance of considering extracolonic manifestations in young patients presenting with colorectal symptoms.
Hamdan A, Zeid RA, Khalil J, Karam K, Fiani E.   +4 more
europepmc   +2 more sources

Hereditary Colon Cancer

Canadian Journal of Gastroenterology, 1997
Hereditary colon cancer comprises approximately 10% of total colon cancer, a disease that affects 6% of the North American population.
Dawna M Gilchrist
doaj   +1 more source

Muir-Torre Syndrome: The Importance of a Detailed Family History

Case Reports in Ophthalmology, 2019
Muir-Torre syndrome, a variant of Lynch syndrome or hereditary nonpolyposis colorectal cancer, is an autosomal dominant disease characterized by skin neoplasms (sebaceous or keratoacanthomas) and visceral malignancies.
Christopher K.H. Burris, Maria E. Rodriguez, Meisha L. Raven, Devasis N. Reddy, Yaohui G. Xu, Janey L. Wiggs, Heather D. Potter, Daniel M. Albert   +7 more
doaj   +1 more source

A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer

Kaohsiung Journal of Medical Sciences, 2011
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant inherited disease predisposing to the development of colorectal cancers and several other malignancies (endometrium, ovaries, stomach, small bowel, hepatobiliary, and urinary ...
Wen-Chau Chen, Shao-Chieh Lin, Jenq-Chang Lee, 陳文超, 林劭潔, 李政昌   +5 more
doaj   +1 more source

Differential diagnosis of small bowel occlusions

Clinical Management Issues, 2009
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI).
Paolo Ghiringhelli
doaj   +1 more source

HISTORY OF HEREDITARY NONPOLYPOSIS COLORECTAL CANCER OR “LYNCH SYNDROME”

Revista Médica Clínica Las Condes, 2017
Hereditary Nonpolyposis Colorectal Cancer (HNPCC or “Lynch syndrome”), involving pathogenic variants in the Mismatch Repair (MMR) genes, is the most common inherited condition that predisposed to colorectal adenomas and colorectal cancer. In this chapter
Patrick M Lynch, JD, MD
doaj   +1 more source