Results 11 to 20 of about 10,784 (208)

Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term results [PDF]

Journal of Coloproctology, 2019
Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that ...
Marisa D. Santos, Cláudio Silva, João Oliveira, Pedro Brandão, Mónica Sampaio, Ana Cristina Silva, Anabela Rocha, Eduarda Matos, Ricardo Marcos-Pinto   +8 more
doaj   +2 more sources

Advanced Colon Cancer Before the Age of 20 Years: A Case for Extension of the Current Colonscopy Surveillance Guidelines in Hereditary Nonpolyposis Colorectal Cancer Syndrome [PDF]

Canadian Journal of Gastroenterology, 2004
BACKGROUND: Hereditary nonpolyposis colorectal cancer (HNPCC) currently accounts for between 2% to 6% of all colorectal adenocarcinomas. Controversies exist regarding the current guidelines for colonoscopic screening for colon cancer.
Victor K Wong, Eric M Yoshida, Anthony G Ryan, Stephen GF Ho, Baljinder Salh   +4 more
doaj   +2 more sources

Hereditary Colon Cancer [PDF]

Canadian Journal of Gastroenterology, 1997
Hereditary colon cancer comprises approximately 10% of total colon cancer, a disease that affects 6% of the North American population.
Dawna M Gilchrist
doaj   +2 more sources

Hyperplastic Polyps in Hereditary Nonpolyposis Colorectal Cancer

American Journal of Gastroenterology, 2003
Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, in particular hMLH1, hMSH2, and hMSH6. Dysfunction of MMR genes leads to loss of MMR protein expression and to microsatellite instability (MSI).
Rijcken, FEM, Van der Sluis, T, Hollema, H, Kleibeuker, JH   +3 more
openaire   +4 more sources

Dominantly Inherited Hereditary Nonpolyposis Colorectal Cancer Not Caused by MMR Genes. [PDF]

J Clin Med, 2020
In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their
Terradas M, Capellá G, Valle L.
europepmc   +2 more sources

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance The discovery of MLH1 -rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques ( MLH1 -rheMac HNPCC), which is an orthologue of Lynch syndrome in ...
Brammer DW, Gillespie PJ, Tian M, Young D, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG.   +20 more
europepmc   +2 more sources

Hereditary nonpolyposis colorectal cancer

Annals of Oncology, 1997
Colorectal cancer is a leading cause of cancer related death in both Europe and the United States. Approximately 20% of cases occur in familial aggregations making this disorder the most frequent form of hereditary neoplasia [1]. Consequently, patients with colorectal cancer often present with a positive family history which may have significant ...
S, O'Reilly, K A, Johnson, J D, Brensinger, F M, Giardiello   +3 more
openaire   +4 more sources

Hereditary Nonpolyposis Colorectal Cancer and Cancer Syndromes: Recent Basic and Clinical Discoveries. [PDF]

J Oncol, 2018
Approximately one-third of individuals diagnosed with colorectal cancer have a family history of cancer, suggesting that CRCs may result from a heritable component.
Chen E, Xu X, Liu T.
europepmc   +2 more sources

Extended microsatellite analysis in microsatellite stable, MSH2 and MLH1 mutation-negative HNPCC patients: Genetic reclassification and correlation with clinical features [PDF]

, 2004
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder predisposing to predominantly colorectal cancer (CRC) and endometrial cancer frequently due to germline mutations in DNA mismatch repair (MMR) genes, mainly ...
Gross, M., Lohse, P., Muders, M., Müller-Koch, Y., Daum, J., Mussack, T., Baretton, G., Kopp, R., Schiemann, Uwe, Holinski-Feder, E.   +9 more
core   +1 more source

Hereditary colorectal cancer : assessment of genotype-phenotype correlations and analysis of rare susceptibility genes in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]

, 2008
Each year 3500 people in Switzerland are diagnosed with colorectal cancer. Approximately 20 percent of all affected patients have two or more first or second-degree relatives with colorectal cancer (at-risk family members). About five percent of these
Necker, Judith
core   +1 more source