Differential diagnosis of small bowel occlusions
Clinical Management Issues, 2009 Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, and microsatellite instability (MSI).
Paolo Ghiringhelli
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Annual outpatient hysteroscopy and endometrial sampling (OHES) in HNPCC/Lynch syndrome (LS) [PDF]
, 2012 Background: LS women have a 40-60 % lifetime risk of endometrial cancer (EC). Most international guidelines recommend screening. However, data on efficacy are limited.
Adam N. Rosenthal +43 more
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HISTORY OF HEREDITARY NONPOLYPOSIS COLORECTAL CANCER OR “LYNCH SYNDROME”
Revista Médica Clínica Las Condes, 2017 Hereditary Nonpolyposis Colorectal Cancer (HNPCC or “Lynch syndrome”), involving pathogenic variants in the Mismatch Repair (MMR) genes, is the most common inherited condition that predisposed to colorectal adenomas and colorectal cancer. In this chapter
Patrick M Lynch, JD, MD
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Frontiers in Oncology, 2022 It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist ...
Adewale Adeoba Ayeni +5 more
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Mutation prediction models in Lynch syndrome: evaluation in a clinical genetic setting [PDF]
, 2009 Background/aims: The identification of Lynch syndrome is hampered by the absence of specific diagnostic features and underutilization of genetic testing.
Kuipers, E.J. (Ernst) +4 more
core +7 more sources
A Comparison Between Denaturing Gradient Gel Electrophoresis and Denaturing High Performance Liquid Chromatography in Detecting Mutations in Genes Associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and the Identification of 9 New Mutations Previously Unidentified by DGGE [PDF]
, 2003 Denaturing high performance liquid chromatography is a relatively new method by which heteroduplex structures formed during the PCR amplification of heterozygote samples can be rapidly identified.
Meldrum Cliff J +8 more
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Historical review of Lynch syndrome
Journal of Coloproctology, 2013 Lynch syndrome was formerly known as Hereditary Nonpolyposis Colorectal Cancer. Currently, these two nomenclatures each have their unique definitions and are no longer used interchangeably.
Andrew I. Wolf +2 more
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Cancer Medicine, 2023 Background Persons with hereditary cancer syndromes (carriers) have a higher risk of developing cancer early. They are confronted with decisions regarding prophylactic surgeries, communication within their families, and childbearing.
Anna Maria Kastner +4 more
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Prevalence of Lynch Syndrome among Patients with Newly Diagnosed Endometrial Cancers [PDF]
, 2013 Background: Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial and other cancers. The identification of endometrial cancer (EC) patients with LS has the potential to influence life-saving interventions.
Alenda, Cristina +17 more
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Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)
Revista de la Facultad de Medicina, 2016 Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
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