Results 71 to 80 of about 16,258 (219)

Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average‐Risk Women

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Objective The gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case–control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi‐center Colorectal Neoplasia Screening with ...
Doratha A. Byrd, Maria F. Gomez, Stephanie R. Hogue, Jessica R. Burns, Nate Smith, Joshua Sampson, Erikka Loftfield, Patricia G. Wolf, Yunhu Wan, Andrew Warner, Belynda Hicks, Casey Dagnall, Kristine Jones, Youngchul Kim, Jin Xu, Jianxin Shi, Rashmi Sinha, Emily Vogtmann   +17 more
wiley   +1 more source

Quality of Life in Adult Individuals Living With or at Risk of a Hereditary Cancer Predisposition Syndrome: A Scoping Review of the Qualitative Literature

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background The in‐depth understanding of the impact of a hereditary cancer predisposition syndrome (HCPS) on the health‐related quality of life (HRQOL) of individuals with a hereditary cancer burden contributes to the improvement of counselling strategies as well as care planning and informs the development of patient‐reported outcome measures
M. Sztankay, S. Wheelwright, V. Vassiliou, E. M. A. Bleiker, B. Rahman, B. Holzner, A. Yener, V. Engele, A. S. Oberguggenberger, EORTC Quality of Life Group   +9 more
wiley   +1 more source

Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels

BMC Medical Genetics, 2009
Background Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality.
Bendahl Pär-Ola, Carlsson Christina, Domanska Katarina, Nilbert Mef   +3 more
doaj   +1 more source

Recognition and management of hereditary colorectal cancer syndromes [PDF]

, 2009
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing
Herraiz-Bayod, M.J. (Maite J.), Muñoz-Navas, M. (Miguel)   +1 more
core  

Frequency of the Common MYH Mutations (G382D and Y165C) in MMR Mutation Positive and Negative HNPCC Patients [PDF]

, 2005
Recently mutations in the MYH gene have been associated with a milder form of adenomatous polyposis which is characterized by a variable level of colonic polyps ranging from a few to several hundred.
Katie A Ashton, Cliff J Meldrum, Mary L McPhillips, Carla F Kairupan, Rodney J Scott   +4 more
core   +1 more source

Germline Cancer Susceptibility Variants in Patients With Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 38, Issue 5, September 2025.
Germline exome sequencing of 106 Finnish patients with UM, considered at higher risk for genetic cancer predisposition, identified pathogenic or likely pathogenic variants associated with varying risk of malignancies in 16 patients (15%). Six patients (6%) carried multiple variants and had a median diagnosis age of 51, compared to 60 in the full cohort
Pauliina E. Repo, Eveliina Jakkula, Juho Hiltunen, Heidi Putkuri, Aleksandra Staskiewicz‐Tuikkanen, Reetta‐Stiina Järvinen, Martin Täll, Virpi Raivio, Rana'a T. Al‐Jamal, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Narrative review comparing the epidemiology, characteristics, and survival in sporadic colorectal carcinoma/Lynch syndrome

Journal of Coloproctology, 2020
Introduction: Colorectal carcinoma is the third most prevalent neoplasm in the world, and the second cause of death by cancer. The most part of these neoplasms are sporadic by somatic mutations, but around 15% are hereditary, such as Lynch syndrome or ...
Maria Beatriz de Matos, Laura Elisabete Barbosa, João Paulo Teixeira   +2 more
doaj   +1 more source

Primary Sclerosing Epithelioid Fibrosarcoma of the Lung in a Patient with Lynch Syndrome [PDF]

, 2018
Sclerosing epithelioid fibrosarcoma (SEF) is a rare neoplasm arising mostly in limbs and limb girdles, with a high rate of recurrence and a strong tendency to metastasize.
Jungraithmayr, Wolfgang, Leisibach, Priska, Soltermann, Alex, Weder, Walter   +3 more
core  

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2. [PDF]

, 2018
BACKGROUND: Variation in an individual\u27s genetic status can impact the development of pancreatic ductal adenocarcinoma; however, the majority of familial pancreatic cancers (FPC) cannot yet be attributed to a specific inherited mutation.
Brody, Jonathan, Cozzitorto, Joseph A., Goetz, Austin, Lavu, Harish, Muller, Alexander J., Nevler, Avinoam, Prendergast, George C., Winter, Jordan M., Yeo, Charles, Yeo, Theresa P.   +9 more
core   +2 more sources

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source