, 1996 Background & Aims: Hereditary nonpolyposis colorectal cancer is characterized by early-onset colorectal cancer and the occurrence of various other cancers, The recent isolation of four mismatch repair genes responsible for hereditary nonpolyposis ...
Kleibeuker, JH +13 more
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Two Cases of Bladder Cancer with Hereditary Nonpolyposis Colorectal Cancer [PDF]
, 2011 Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by an excess of extracolonic malignancies including those of the urinary tract. We report two cases of bladder tumor associated with HNPCC.
辻畑, 正雄 +5 more
core
Small bowel carcinoma in hereditary nonpolyposis colorectal cancer
, 1998 A 53-yr-old man, a member of a hereditary nonpolyposis colorectal cancer (HNPCC) family, with previous colonoscopic polypectomies, presented for persisting vomiting and marked signs of dehydration. Previous radiological and endoscopic examinations of the
Fante, Rossella +14 more
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The story of hereditary nonpolyposis colorectal cancer: celebrating the spirit of investigation. [PDF]
IGIE, 2023 Lynch PM, Ge PS.
europepmc +1 more source
A cost-effective algorithm for hereditary nonpolyposis colorectal cancer detection.
, 2006 Colorectal cancer with microsatellite instability (MSI) may occur sporadically or be inherited in cases of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. However, there is no consensus as to which patients must be tested and how to test MSI.
Bouzourene, H. +9 more
core +1 more source
SPECIAL FEATURES OF CARCINOGENESIS OF COLON ADENOCARCINOMA
Сибирский онкологический журнал, 2016 Colorectal cancer is one of the most common malignancies and the leading cause of cancer-related death. There are 4 basic colon carcinogenic steps: malignant transformation of adenoma into carcinoma; HNPCC (hereditary nonpolyposis colon cancer); cancer ...
G. A. Raskin, S. V. Petrov, R. V. Orlova
doaj
Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer. [PDF]
Cancer Med, 2023 Ha YJ +9 more
europepmc +1 more source
Urinary tract cancer and hereditary nonpolyposis colorectal cancer:Risks and screening options
, 1998 Purpose: We investigate the risk of the different types of urinary tract cancer in hereditary nonpolyposis colorectal cancer families and review screening options.Materials and Methods: We retrospectively calculated the relative and cumulative risks of ...
Witjes, JA +3 more
core
N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα
, 2006 Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Trojan, Jörg +4 more
core +1 more source
Numbers of mutations to different types of colorectal cancer
BMC Cancer, 2005 Background The numbers of oncogenic mutations required for transformation are uncertain but may be inferred from how cancer frequencies increase with aging. Cancers requiring more mutations will tend to appear later in life.
Tavaré Simon +5 more
doaj +1 more source