Results 91 to 100 of about 16,555 (261)

Does sex of the patient play a role in survival for MSI colorectal cancer? [PDF]

, 2018
Microsatellite instability (MSI) is a feature of colorectal tumors that develops as a result of inactivation of the DNA mismatch repair system. It is found in about 15% of all colorectal cancers and is an important prognostic molecular marker when ...
Alecu, Lucian, Hainarosie, Razvan, Iaciu, Cristian I., Jecan, Radu C., Nitipir, Cornelia, Orlov, Cristina, Pantea Stoian, Anca, Pituru, Silviu, Slavu, Iulian, Stanculeanu, Dana L., Tulin, Adrian, Tulin, Raluca   +11 more
core   +3 more sources

Lung adenocarcinoma and colorectal cancer as double primary malignancies reveal lynch syndrome: a case report of germline MLH1 mutation with response to immunotherapy and familial aggregation

Frontiers in Immunology
Lynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer, is a genetic condition that increases the risk of developing colorectal cancer (CRC) and other cancers due to defective DNA mismatch repair (dMMR).
Menglei Wang, Haoyue Xue, Jiamin Hong, Qi Liu, Keke Hu, Chang Shu, Jinghua Wang, Yu Long, Yehong Han, Xuefei Yang, Jinhua Lu   +10 more
doaj   +1 more source

Three synchronous primary carcinomas in a patient with HNPCC associated with a novel germline mutation in MLH1: Case report

World Journal of Surgical Oncology, 2009
Background MLH1 is one of six known genes responsible for DNA mismatch repair (MMR), whose inactivation leads to HNPCC. It is important to develop genotype-phenotype correlations for HNPCC, as is being done for other hereditary cancer syndromes, in order
Yee Herman, Reich Elsa W, Huang William C, Moore Harvey G, Valenzuela Cristian D, Ostrer Harry, Pachter H Leon   +6 more
doaj   +1 more source

DNA Methylation and MicroRNAs as Biomarkers in Hereditary Nonpolyposis of Colorectal Cancer Patients: A Systematic Review

, 2023
Gregorio Rangel
openalex   +2 more sources

Pancreatic Cancer in Lynch Syndrome Patients [PDF]

, 2017
Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors.
Bujanda Fernández de Pierola, Luis, Herreros Villanueva, Marta   +1 more
core   +3 more sources

Hereditary Nonpolyposis Colorectal Cancer in Association with Crohn's Disease and Lynch Syndrome: The Importance of a Strict Endoscopic Surveillance. [PDF]

Case Rep Gastroenterol, 2022
Hahn GD, Wetwittayakhlang P, Afif W, Bessissow T, Lakatos PL.   +4 more
europepmc   +1 more source

The genetic basis of Lynch syndrome and its implications for clinical practice and risk management

The Application of Clinical Genetics, 2014
Stephanie A Cohen,1 Anna Leininger2 1Cancer Genetics Risk Assessment Program, St Vincent Health, Indianapolis, IN, USA; 2Minnesota Oncology, Woodbury, MN, USA Abstract: Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for
Cohen SA, Leininger A
doaj  

Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients

BMC Cancer, 2017
Background The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM.
Jasmine Lee, Yin-Yi Xiao, Yan Yu Sun, Jasminka Balderacchi, Bradley Clark, Jatin Desani, Vivek Kumar, Angela Saverimuthu, Khin Than Win, Yiwu Huang, Yiqing Xu   +10 more
doaj   +1 more source

Primary Sclerosing Epithelioid Fibrosarcoma of the Lung in a Patient with Lynch Syndrome [PDF]

, 2018
Sclerosing epithelioid fibrosarcoma (SEF) is a rare neoplasm arising mostly in limbs and limb girdles, with a high rate of recurrence and a strong tendency to metastasize.
Jungraithmayr, Wolfgang, Leisibach, Priska, Soltermann, Alex, Weder, Walter   +3 more
core  

Clinical and genetic aspects of differential diagnostics of hereditary non-polyposis colorectal cancer

Успехи молекулярной онкологии, 2019
Lynch syndrome was synonymous with hereditary non-polyposis colorectal cancer for a long time, however, mapping of the DNA mismatch repair (MMR) genes has led to distinguish Lynch syndrome as an independent syndromic unit from a number of Lynch-like ...
A. V. Semyanikhina, A. O. Rasulov, L. N. Lyubchenko   +2 more
doaj   +1 more source