The genetic basis of Lynch syndrome and its implications for clinical practice and risk management
The Application of Clinical Genetics, 2014 Stephanie A Cohen,1 Anna Leininger2 1Cancer Genetics Risk Assessment Program, St Vincent Health, Indianapolis, IN, USA; 2Minnesota Oncology, Woodbury, MN, USA Abstract: Lynch syndrome is the most common cause of hereditary colon cancer, and accounts for
Cohen SA, Leininger A
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BMC Cancer, 2017 Background The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM.
Jasmine Lee +10 more
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Hereditary Nonpolyposis Colorectal Cancer in Association with Crohn's Disease and Lynch Syndrome: The Importance of a Strict Endoscopic Surveillance. [PDF]
Case Rep Gastroenterol, 2022 Hahn GD +4 more
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Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer [PDF]
, 2000 Heikki Järvinen +7 more
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PLoS ONE, 2014 Aberrant telomere length measured in blood has been associated with increased risk of several cancer types. In the field of hereditary non-polyposis colorectal cancer (CRC), and more particularly in Lynch syndrome, caused by germline mutations in the ...
Nuria Seguí +9 more
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Deficient DNA mismatch repair and persistence of SARS-CoV-2 RNA shedding: a case report of hereditary nonpolyposis colorectal cancer with COVID-19 infection. [PDF]
BMC Infect Dis, 2021 Haque F, Lillie P, Haque F, Maraveyas A.
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Deciding the operation type according to mismatch repair status among hereditary nonpolyposis colorectal cancer patients: should a tailored approach be applied, or does one size fit all? [PDF]
Hered Cancer Clin Pract, 2021 Liao CK +5 more
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Journal of Research in Medical Sciences, 2012 Background: There is a lack of data on familial aggregation of colorectal cancer (CRC) in Iran. We aimed to deter-mine the frequency of hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) and to determine the frequency ...
Amin Nemati +3 more
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GSTM1 Polymorphism Does Not Affect Hereditary Nonpolyposis Colorectal Cancer Age of Onset [PDF]
, 2004 J. Shawn Jones +5 more
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