Results 161 to 170 of about 10,129 (212)

Rectal cancer in hereditary nonpolyposis colorectal cancer

American Journal of Surgery, 2001
Hereditary nonpolyposis colorectal cancer (HNPCC) accounts for approximately 2% to 5% of all colorectal cancers. Rectal cancer in HNPCC is not well characterized.A retrospective medical record review of HNPCC patients with colorectal cancer diagnosis from December 1948 to December 1999 was performed in an attempt to elucidate the natural history of ...
Nicholas J Petrelli, MIGUEL A Rodriguez-Bigas   +1 more
exaly   +3 more sources

A role for MLH3 in hereditary nonpolyposis colorectal cancer

Nature Genetics, 2001
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for mutations in 39 HNPCC families and in 288 patients suspected of having HNPCC. We identified ten different germline MLH3 variants, one frameshift and nine missense mutations, in 12 patients suspected of HNPCC.
Wu, Y, Berends, MJW, Sijmons, RH, Mensink, RGJ, Verlind, E, Kooi, KA, van der Sluis, T, Kempinga, C, van der Zee, AGJ, Hollema, H, Buys, CHCM, Kleibeuker, JH, Hofstra, RMW   +12 more
core   +5 more sources

Hereditary nonpolyposis colorectal cancer

Seminars in Surgical Oncology, 2000
Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, is the most common form of hereditary colorectal cancer (CRC). A well-orchestrated cancer family history is essential for its diagnosis since, unlike its familial adenomatous polyposis (FAP) hereditary cancer counterpart, HNPCC lacks distinguishing clinical stigmata of its cancer ...
H T, Lynch, J F, Lynch
openaire   +4 more sources

Hereditary Nonpolyposis Colorectal Cancer

Scandinavian Journal of Gastroenterology, 1994
(1994). Hereditary Nonpolyposis Colorectal Cancer. Scandinavian Journal of Gastroenterology: Vol. 29, No. 8, pp. 673-677.
J P, Mecklin, L B, Svendsen, P, Peltomäki, H F, Vasen   +3 more
openaire   +2 more sources

[Hereditary nonpolyposis colorectal cancer].

Nihon rinsho. Japanese journal of clinical medicine, 2004
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer (CRC). The disease carries a >80% lifetime risk of CRC (mean age at diagnosis being 46 years). The CRCs that arise in HNPCC are usually right-sided and associated with synchronous and metachronous tumors.
Masaaki, Matsukawa, Terushige, Yamamoto, Takahiko, Kouda   +2 more
  +5 more sources

Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer

Cancer, 1990
It has been hypothesized that in some but not all families with hereditary nonpolyposis colorectal cancer (HNPCC) there is a high risk of certain cancers other than colon cancer.The authors compared the observed frequency of cancer at specific sites in more than 1300 high-risk members of 23 kindreds with HNPCC with expectations based on general ...
P, Watson, H T, Lynch
openaire   +2 more sources

Identifying Hereditary Nonpolyposis Colorectal Cancer

New England Journal of Medicine, 1998
The recent discovery of the genetic basis of certain familial aggregations of colorectal cancer validated 90 years of clinical observation suggesting that such aggregations are hereditary.1 It also...
H T, Lynch, T C, Smyrk
openaire   +2 more sources

Hyperplastic Polyps in Hereditary Nonpolyposis Colorectal Cancer

American Journal of Gastroenterology, 2003
Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, in particular hMLH1, hMSH2, and hMSH6. Dysfunction of MMR genes leads to loss of MMR protein expression and to microsatellite instability (MSI).
Rijcken, FEM, Van der Sluis, T, Hollema, H, Kleibeuker, JH   +3 more
openaire   +3 more sources

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

New England Journal of Medicine, 1998
Background Genetic disorders that predispose people to colorectal cancer include the polyposis syndromes and hereditary nonpolyposis colorectal cancer.
Lauri A Aaltonen, Reijo Salovaara, P Kristo   +2 more
exaly   +3 more sources

Pathology of Hereditary Nonpolyposis Colorectal Cancer

Annals of the New York Academy of Sciences, 2000
Abstract: The magnitude of the pathologist's role in the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) is underestimated. The diagnostic features are not specific to HNPCC cancers, but relate to all cancers showing high levels of DNA microsatellite instability (MSI‐H).
openaire   +6 more sources