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Blurring the Lines: Co-Occurrence of MSH6 Variant and MLH1 Constitutional Epimutation in a Young Colorectal Cancer Patient. [PDF]

Clin Genet
Shtaya AA, Hadid Y, Mahamid A, Kidron D, Halpern N, Shalata A, Levi Z, Goldberg Y.   +7 more
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[Hereditary nonpolyposis colorectal cancer].

Nihon rinsho. Japanese journal of clinical medicine, 2004
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer (CRC). The disease carries a >80% lifetime risk of CRC (mean age at diagnosis being 46 years). The CRCs that arise in HNPCC are usually right-sided and associated with synchronous and metachronous tumors.
Masaaki, Matsukawa, Terushige, Yamamoto, Takahiko, Kouda   +2 more
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Hereditary nonpolyposis colorectal cancer

Seminars in Surgical Oncology, 2000
Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, is the most common form of hereditary colorectal cancer (CRC). A well-orchestrated cancer family history is essential for its diagnosis since, unlike its familial adenomatous polyposis (FAP) hereditary cancer counterpart, HNPCC lacks distinguishing clinical stigmata of its cancer ...
H T, Lynch, J F, Lynch
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Hereditary Nonpolyposis Colorectal Cancer

Scandinavian Journal of Gastroenterology, 1994
(1994). Hereditary Nonpolyposis Colorectal Cancer. Scandinavian Journal of Gastroenterology: Vol. 29, No. 8, pp. 673-677.
J P, Mecklin, L B, Svendsen, P, Peltomäki, H F, Vasen   +3 more
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Identifying Hereditary Nonpolyposis Colorectal Cancer

New England Journal of Medicine, 1998
The recent discovery of the genetic basis of certain familial aggregations of colorectal cancer validated 90 years of clinical observation suggesting that such aggregations are hereditary.1 It also...
H T, Lynch, T C, Smyrk
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Extracolonic Cancer in Hereditary Nonpolyposis Colorectal Cancer

Cancer, 1990
It has been hypothesized that in some but not all families with hereditary nonpolyposis colorectal cancer (HNPCC) there is a high risk of certain cancers other than colon cancer.The authors compared the observed frequency of cancer at specific sites in more than 1300 high-risk members of 23 kindreds with HNPCC with expectations based on general ...
P, Watson, H T, Lynch
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