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Hereditary Nonpolyposis Colorectal Cancer
2007Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until ...
Erik C. Thorland, Stephen N. Thibodeau
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Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer
The American Surgeon, 2003Approximately 80 per cent of patients with colorectal cancer have sporadic disease whereas the remaining 20 per cent seem to have a genetic component. Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common autosomal dominant hereditary syndrome predisposing to colorectal cancer.
Rebecca, Hoedema +6 more
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Hereditary nonpolyposis colorectal cancer: preventive management
Cancer Treatment Reviews, 2003Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. Inherited mutations in the mismatch repair genes associated with this syndrome have an approximate 80% lifetime risk of colorectal cancer. Since there are no premonitory signs of susceptibility to HNPCC, family history is the initial method for ...
Hwei-Ju, Annie Yu +3 more
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Hereditary Nonpolyposis Colorectal Cancer
2010Hereditary nonpolyposis colorectal cancer (HNPCC) is one of two distinct inherited colorectal cancer syndromes with known genetic defects. It is estimated to account for approximately 5% of all large bowel cancers. Originally called Lynch syndrome after Dr. Henry Lynch, it is an autosomal dominant disorder characterized by a predilection for colorectal
W. Donald Buie, Anthony R. MacLean
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[Hereditary nonpolyposis colorectal cancers].
Praxis, 1996Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited disease leading to a marked increase in cancer susceptibility, notably colorectal cancer, affecting up to one in 400 individuals in the Western world. Four genes responsible for the majority of cases have been identified.
S, Caplin, M T, Constanda, J C, Givel
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Segregation analysis of hereditary nonpolyposis colorectal cancer
Genetic Epidemiology, 1986AbstractSegregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a major autosomal dominant gene for hereditary nonpolyposis colorectal cancer. It was estimated that between 71% and 79% of the gene carriers were susceptible and had age of onset that was normally distributed with mean ...
Joan E. Bailey‐Wilson +7 more
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Recent Developments in Hereditary Nonpolyposis Colorectal Cancer
Scandinavian Journal of Gastroenterology, 1996Hereditary non-polyposis colorectal cancer (HNPCC) is characterized by early onset of colorectal carcinoma (CRC), usually located proximally to the splenic flexure and reportedly carrying a better survival as compared to sporadic-type CRC. Depending on the absence or presence of extracolonic tumours, particularly carcinomas of the endometrium, stomach ...
M E, Craanen +3 more
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[Hereditary nonpolyposis colorectal cancer].
Ugeskrift for laeger, 1996Hereditary non polypous colon cancer (HNPCC) is inherited in a dominant fashion, and accounts for 29-39% of all colon and rectum carcinomas occurring in people under 50 years of age. We present a case of a young male with a short history of fluctuating diarrhoea and bleeding per rectum. Family records showed a high incidence of colon and rectum cancer.
C, Eithz, H T, Vaesel, T A, Knudsen
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Establishment of a hereditary nonpolyposis colorectal cancer registry
Diseases of the Colon & Rectum, 1996Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition characterized by early age of onset colorectal cancer, right-sided predominance, excess of synchronous and metachronous colonic neoplasms, and extracolonic cancers. The purpose of this study is to report clinical characteristics of HNPCC families in our registry.This ...
M A, Rodríguez-Bigas +6 more
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Surgical Management of Hereditary Nonpolyposis Colorectal Cancer
Advances in Surgery, 2011HNPCC is a diverse disease with significant colorectal and extracolonic malignancy risk. A high index of suspicion is necessary to identify patients and families who potentially have this disease. Patients suspected with Lynch syndrome should be referred for genetic counseling and testing for accurate diagnosis. Timely surveillance and intervention are
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