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Hereditary Nonpolyposis Colorectal Cancer
2007Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant colon cancer syndrome. The first description of a cancer-prone family with HNPCC dates back to the late 1800s.1 However, it was not until the work of Lynch in the 1970s that a more complete clinical picture of this disorder began to emerge.2,3 The diagnosis of HNPCC has, until ...
Erik C. Thorland, Stephen N. Thibodeau
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Genetic testing for hereditary nonpolyposis colorectal cancer
Current Opinion in Gastroenterology, 2003Colorectal cancer remains a major cause of morbidity and mortality in United States. While most newly diagnosed cases are sporadic, a small percent of colorectal cancers are due to hereditary cancer syndromes, of which hereditary nonpolyposis colorectal cancer (HNPCC) is the most common.
Deepa, Jagadeesh, Sapna, Syngal
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Hyperplastic Polyps in Hereditary Nonpolyposis Colorectal Cancer
American Journal of Gastroenterology, 2003Hereditary nonpolyposis colorectal cancer (HNPCC) is a genetic syndrome caused by germline mutations in DNA mismatch repair (MMR) genes, in particular hMLH1, hMSH2, and hMSH6. Dysfunction of MMR genes leads to loss of MMR protein expression and to microsatellite instability (MSI).
Rijcken, FEM +3 more
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Hereditary nonpolyposis colorectal cancer: preventive management
Cancer Treatment Reviews, 2003Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. Inherited mutations in the mismatch repair genes associated with this syndrome have an approximate 80% lifetime risk of colorectal cancer. Since there are no premonitory signs of susceptibility to HNPCC, family history is the initial method for ...
Hwei-Ju, Annie Yu +3 more
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Rectal cancer in hereditary nonpolyposis colorectal cancer
The American Journal of Surgery, 2001Hereditary nonpolyposis colorectal cancer (HNPCC) accounts for approximately 2% to 5% of all colorectal cancers. Rectal cancer in HNPCC is not well characterized.A retrospective medical record review of HNPCC patients with colorectal cancer diagnosis from December 1948 to December 1999 was performed in an attempt to elucidate the natural history of ...
J S, Lee +2 more
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Hereditary Nonpolyposis Colorectal Cancer
2010Hereditary nonpolyposis colorectal cancer (HNPCC) is one of two distinct inherited colorectal cancer syndromes with known genetic defects. It is estimated to account for approximately 5% of all large bowel cancers. Originally called Lynch syndrome after Dr. Henry Lynch, it is an autosomal dominant disorder characterized by a predilection for colorectal
W. Donald Buie, Anthony R. MacLean
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[Hereditary nonpolyposis colorectal cancer].
Ugeskrift for laeger, 1996Hereditary non polypous colon cancer (HNPCC) is inherited in a dominant fashion, and accounts for 29-39% of all colon and rectum carcinomas occurring in people under 50 years of age. We present a case of a young male with a short history of fluctuating diarrhoea and bleeding per rectum. Family records showed a high incidence of colon and rectum cancer.
C, Eithz, H T, Vaesel, T A, Knudsen
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Recent Developments in Hereditary Nonpolyposis Colorectal Cancer
Scandinavian Journal of Gastroenterology, 1996Hereditary non-polyposis colorectal cancer (HNPCC) is characterized by early onset of colorectal carcinoma (CRC), usually located proximally to the splenic flexure and reportedly carrying a better survival as compared to sporadic-type CRC. Depending on the absence or presence of extracolonic tumours, particularly carcinomas of the endometrium, stomach ...
M E, Craanen +3 more
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[Hereditary nonpolyposis colorectal cancers].
Praxis, 1996Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited disease leading to a marked increase in cancer susceptibility, notably colorectal cancer, affecting up to one in 400 individuals in the Western world. Four genes responsible for the majority of cases have been identified.
S, Caplin, M T, Constanda, J C, Givel
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Gynecologic screening in hereditary nonpolyposis colorectal cancer
Gynecologic Oncology, 2003In hereditary nonpolyposis colorectal cancer (HNPCC), women with a mismatch repair (MMR) gene mutation have a cumulative lifetime risk of 25-50% for endometrial cancer and 8-12% for ovarian cancer. Therefore, female members of HNPCC families are offered an annual gynecologic and transvaginal ultrasound (TVU) examination and serum level CA 125 analysis.
Rijcken, FEM +4 more
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