Results 181 to 190 of about 9,940 (218)
Some of the next articles are maybe not open access.
Pathology of Hereditary Nonpolyposis Colorectal Cancer
Annals of the New York Academy of Sciences, 2000Abstract: The magnitude of the pathologist's role in the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) is underestimated. The diagnostic features are not specific to HNPCC cancers, but relate to all cancers showing high levels of DNA microsatellite instability (MSI‐H).
openaire +2 more sources
Segregation analysis of hereditary nonpolyposis colorectal cancer
Genetic Epidemiology, 1986AbstractSegregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a major autosomal dominant gene for hereditary nonpolyposis colorectal cancer. It was estimated that between 71% and 79% of the gene carriers were susceptible and had age of onset that was normally distributed with mean ...
Joan E. Bailey‐Wilson +7 more
openaire +2 more sources
Hereditary nonpolyposis colorectal cancer and related conditions
American Journal of Medical Genetics Part A, 2003AbstractHereditary nonpolyposis colorectal cancer (HNPCC) is a cancer‐predisposing condition caused by inactivating mutations in at least four genes (MSH2, MLH1, MSH6, and PMS2) belonging to the mismatch repair system. At present, availability of the microsatellite instability (MSI) test allows screening of a relevant fraction of patients with a ...
LUCCI CORDISCO E. +3 more
openaire +3 more sources
Surgical Management of Hereditary Nonpolyposis Colorectal Cancer
Advances in Surgery, 2011HNPCC is a diverse disease with significant colorectal and extracolonic malignancy risk. A high index of suspicion is necessary to identify patients and families who potentially have this disease. Patients suspected with Lynch syndrome should be referred for genetic counseling and testing for accurate diagnosis. Timely surveillance and intervention are
openaire +2 more sources
Current Approaches in Hereditary Nonpolyposis Colorectal Cancer
Journal of the National Comprehensive Cancer Network, 2012This article emphasizes the central role of tumor-based testing for microsatellite instability followed by performance of genetic counselor-driven germline mutation testing in hereditary nonpolyposis colorectal cancer (HNPCC). Suitably aggressive colorectal neoplasm surveillance is shown to be critical.
openaire +2 more sources
Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer
1997Since 1993 four genes have been identified that, when mutated, confer predisposition to a form of hereditary colon cancer (hereditary nonpolyposis colorectal cancer [HNPCC]). These genes belong to the Mut-related family of DNA mismatch repair genes whose protein products are responsible for the recognition and correction of errors that arise during DNA
P, Peltomäki, A, de la Chapelle
openaire +2 more sources
Molecular Genetics of Hereditary Nonpolyposis Colorectal Cancer
Annals of the New York Academy of Sciences, 2000Abstract: The initial paradigm developed for colorectal carcinogenesis was derived from the observation that these tumors suffer a large number of chromosomal losses. This phenomenon results from unbalanced mitoses, and to date there is no clear explanation for this type of genomic instability.
openaire +2 more sources
Colorectal cancer statistics, 2023
Ca-A Cancer Journal for Clinicians, 2023Rebecca L Siegel +2 more
exaly
Clinical management of metastatic colorectal cancer in the era of precision medicine
Ca-A Cancer Journal for Clinicians, 2022Fortunato Ciardiello +2 more
exaly
Hereditary nonpolyposis colorectal cancer (HNPCC)
Cytogenetic and Genome Research, 1999openaire +2 more sources