Results 181 to 190 of about 10,129 (212)

Hereditary nonpolyposis colorectal cancer and related conditions

American Journal of Medical Genetics Part A, 2003
AbstractHereditary nonpolyposis colorectal cancer (HNPCC) is a cancer‐predisposing condition caused by inactivating mutations in at least four genes (MSH2, MLH1, MSH6, and PMS2) belonging to the mismatch repair system. At present, availability of the microsatellite instability (MSI) test allows screening of a relevant fraction of patients with a ...
LUCCI CORDISCO E., ZITO I., GENSINI, FRANCESCA, GENUARDI, MAURIZIO   +3 more
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The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

The American Journal of Medicine, 1994
Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative
P, Watson, H F, Vasen, J P, Mecklin, H, Järvinen, H T, Lynch   +4 more
openaire   +2 more sources

Current Approaches in Hereditary Nonpolyposis Colorectal Cancer

Journal of the National Comprehensive Cancer Network, 2012
This article emphasizes the central role of tumor-based testing for microsatellite instability followed by performance of genetic counselor-driven germline mutation testing in hereditary nonpolyposis colorectal cancer (HNPCC). Suitably aggressive colorectal neoplasm surveillance is shown to be critical.
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Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer

1997
Since 1993 four genes have been identified that, when mutated, confer predisposition to a form of hereditary colon cancer (hereditary nonpolyposis colorectal cancer [HNPCC]). These genes belong to the Mut-related family of DNA mismatch repair genes whose protein products are responsible for the recognition and correction of errors that arise during DNA
P, Peltomäki, A, de la Chapelle
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Molecular Genetics of Hereditary Nonpolyposis Colorectal Cancer

Annals of the New York Academy of Sciences, 2000
Abstract: The initial paradigm developed for colorectal carcinogenesis was derived from the observation that these tumors suffer a large number of chromosomal losses. This phenomenon results from unbalanced mitoses, and to date there is no clear explanation for this type of genomic instability.
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HEREDITARY NONPOLYPOSIS COLORECTAL CANCER

2005
Kevin M. Lin, Alan G. Thorson
openaire   +2 more sources

Hereditary nonpolyposis colorectal cancer (HNPCC)

Cytogenetic and Genome Research, 1999
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HEREDITARY NONPOLYPOSIS COLORECTAL CANCER

Journal of Wound, Ostomy and Continence Nursing, 2003
Tamra Holloway, Mary Ann Brooks
openaire   +1 more source

Diagnostic Approach and Management of Lynch Syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A Guide for Clinicians

Ca-A Cancer Journal for Clinicians, 2006
H Morreau, H F A Vasen, M H Breuning
exaly  

Hereditary Colon Cancer: Polyposis and Nonpolyposis Variants

Ca-A Cancer Journal for Clinicians, 1985
Henry T Lynch, Paul Rozen, Guy S Schuelke   +2 more
exaly