Results 181 to 190 of about 15,648 (219)

Recent Developments in Hereditary Nonpolyposis Colorectal Cancer

Scandinavian Journal of Gastroenterology, 1996
Hereditary non-polyposis colorectal cancer (HNPCC) is characterized by early onset of colorectal carcinoma (CRC), usually located proximally to the splenic flexure and reportedly carrying a better survival as compared to sporadic-type CRC. Depending on the absence or presence of extracolonic tumours, particularly carcinomas of the endometrium, stomach ...
M E, Craanen, P, Blok, G J, Offerhaus, G N, Tytgat   +3 more
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[Hereditary nonpolyposis colorectal cancers].

Praxis, 1996
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal, dominantly inherited disease leading to a marked increase in cancer susceptibility, notably colorectal cancer, affecting up to one in 400 individuals in the Western world. Four genes responsible for the majority of cases have been identified.
S, Caplin, M T, Constanda, J C, Givel
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Gynecologic screening in hereditary nonpolyposis colorectal cancer

Gynecologic Oncology, 2003
In hereditary nonpolyposis colorectal cancer (HNPCC), women with a mismatch repair (MMR) gene mutation have a cumulative lifetime risk of 25-50% for endometrial cancer and 8-12% for ovarian cancer. Therefore, female members of HNPCC families are offered an annual gynecologic and transvaginal ultrasound (TVU) examination and serum level CA 125 analysis.
Rijcken, FEM, Mourits, MJE, Kleibeuker, JH, Hollema, H, van der Zee, AGJ   +4 more
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Pathology of Hereditary Nonpolyposis Colorectal Cancer

Annals of the New York Academy of Sciences, 2000
Abstract: The magnitude of the pathologist's role in the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) is underestimated. The diagnostic features are not specific to HNPCC cancers, but relate to all cancers showing high levels of DNA microsatellite instability (MSI‐H).
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Segregation analysis of hereditary nonpolyposis colorectal cancer

Genetic Epidemiology, 1986
AbstractSegregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a major autosomal dominant gene for hereditary nonpolyposis colorectal cancer. It was estimated that between 71% and 79% of the gene carriers were susceptible and had age of onset that was normally distributed with mean ...
Joan E. Bailey‐Wilson, Robert C. Elston, Guy S. Schuelke, William Kimberling, William Albano, Jane F. Lynch, Henry T. Lynch, D. C. Rao   +7 more
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Hereditary nonpolyposis colorectal cancer and related conditions

American Journal of Medical Genetics Part A, 2003
AbstractHereditary nonpolyposis colorectal cancer (HNPCC) is a cancer‐predisposing condition caused by inactivating mutations in at least four genes (MSH2, MLH1, MSH6, and PMS2) belonging to the mismatch repair system. At present, availability of the microsatellite instability (MSI) test allows screening of a relevant fraction of patients with a ...
LUCCI CORDISCO E., ZITO I., GENSINI, FRANCESCA, GENUARDI, MAURIZIO   +3 more
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Surgical Management of Hereditary Nonpolyposis Colorectal Cancer

Advances in Surgery, 2011
HNPCC is a diverse disease with significant colorectal and extracolonic malignancy risk. A high index of suspicion is necessary to identify patients and families who potentially have this disease. Patients suspected with Lynch syndrome should be referred for genetic counseling and testing for accurate diagnosis. Timely surveillance and intervention are
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Current Approaches in Hereditary Nonpolyposis Colorectal Cancer

Journal of the National Comprehensive Cancer Network, 2012
This article emphasizes the central role of tumor-based testing for microsatellite instability followed by performance of genetic counselor-driven germline mutation testing in hereditary nonpolyposis colorectal cancer (HNPCC). Suitably aggressive colorectal neoplasm surveillance is shown to be critical.
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Ca-A Cancer Journal for Clinicians, 2021
Hyuna Sung, Jacques Ferlay, Rebecca L Siegel   +2 more
exaly  

Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer

1997
Since 1993 four genes have been identified that, when mutated, confer predisposition to a form of hereditary colon cancer (hereditary nonpolyposis colorectal cancer [HNPCC]). These genes belong to the Mut-related family of DNA mismatch repair genes whose protein products are responsible for the recognition and correction of errors that arise during DNA
P, Peltomäki, A, de la Chapelle
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