Results 11 to 20 of about 9,940 (218)

Hereditary Nonpolyposis Colorectal Cancer [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Diagnostics [PDF]

JNCI Journal of the National Cancer Institute, 2007
Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance.
Kristina Lagerstedt‐Robinson, Thalia D. Liu, Jana Vandrovcová, B. Halvarsson, Mark Clendenning, Thierry Frébourg, Nikolaos G. Papadopoulos, K. W. Kinzler, Bert Vogelstein, Païvi Peltomäki, Richard D. Kolodner, Mef Nilbert, Annika Lindblom   +12 more
openalex   +3 more sources

Hereditary nonpolyposis colorectal cancer

Annals of Oncology, 1997
Colorectal cancer is a leading cause of cancer related death in both Europe and the United States. Approximately 20% of cases occur in familial aggregations making this disorder the most frequent form of hereditary neoplasia [1]. Consequently, patients with colorectal cancer often present with a positive family history which may have significant ...
S, O'Reilly, K A, Johnson, J D, Brensinger, F M, Giardiello   +3 more
openaire   +4 more sources

High Grade Dysplastic Rectal Adenoma in a Young Patient With Café-Au-Lait Spots: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Colorectal cancer screening guidelines typically focus on familial history and age‐related risk factors, yet Café‐au‐lait macules could serve as early indicators for tailored surveillance protocols. This case underscores the importance of considering extracolonic manifestations in young patients presenting with colorectal symptoms.
Hamdan A, Zeid RA, Khalil J, Karam K, Fiani E.   +4 more
europepmc   +2 more sources

Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes.
Rasool M, Haque A, Alharthi M, Ali T, Karim S, Mira LS, Al-Abbasi F, Aljiffry M, Ghunaim M, Sibiany A, Pushparaj PN.   +10 more
europepmc   +2 more sources

Case Report: Multiple colorectal cancers in a patient with Ulcerative colitis and Lynch syndrome: Is there a role for prophylactic colectomy? A short report and review of literature

Frontiers in Oncology, 2022
It is a known fact that Lynch syndrome (LS) and Ulcerative colitis (UC) are individually associated with increased risk of colorectal cancer. While there is no conclusive evidence to demonstrate a cumulative risk when these two conditions coexist ...
Adewale Adeoba Ayeni, Peter Waterland, Matthew Evans, Shika Singhal, Rajan Kumar Patel, Akinfemi Akingboye   +5 more
doaj   +1 more source

Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. [PDF]

PLoS ONE, 2013
Heredity is estimated to cause at least 20% of colorectal cancer. The hereditary nonpolyposis colorectal cancer subset is divided into Lynch syndrome and familial colorectal cancer type X (FCCTX) based on presence of mismatch repair (MMR) gene defects.We
Mev Dominguez-Valentin, Christina Therkildsen, Srinivas Veerla, Mats Jönsson, Inge Bernstein, Ake Borg, Mef Nilbert   +6 more
doaj   +1 more source

Hereditary nonpolyposis colorectal cancer identification and surveillance of high-risk families Câncer colo-retal hereditário não polipose - Diagnóstico e surgimento de famílias de alto risco

Clinics, 2005
Hereditary nonpolyposis colorectal cancer is an autosomal dominant condition caused by highly penetrant gene mutations. It is characterized by increased susceptibility for a specific group of cancer, mainly colorectal cancer. The syndrome originates from
Roberta Vasconcelos e Silva, Bernardo Garicochea, Guilherme Cotti, Isabel Cristina Maranho, Raul Cutait   +4 more
doaj   +1 more source

A rare case of Turcot syndrome [PDF]

Journal of Clinical and Scientific Research, 2015
Turcot’s syndrome is a rare genetic disorder clinically characterised by concomitant occurrence of primary brain tumour and colorectal polyposis. It is commonly seen in association with two other syndromes, namely, hereditary nonpolyposis colorectal ...
Sarma YS, Bhaskararao G, Sriharibabu M, Chakravarthy DJK   +3 more
doaj   +1 more source

Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term results

Journal of Coloproctology, 2019
Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that ...
Marisa D. Santos, Cláudio Silva, João Oliveira, Pedro Brandão, Mónica Sampaio, Ana Cristina Silva, Anabela Rocha, Eduarda Matos, Ricardo Marcos-Pinto   +8 more
doaj   +1 more source