Results 21 to 30 of about 10,129 (212)

Identification of novel genetic and prognostic markers in hereditary and sporadic cancer: "two sides of the same coin" [PDF]

, 2012
This thesis has focused on the discovery and characterization of novel diagnostic and prognostic markers in various cancer entities, with a special emphasis on colorectal cancer (CRC).
Piscuoglio, Salvatore
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Clinical Discovery and Molecular Analysis of Two Novel MSH2 Gene Mutations (p.Ala771Gly and p.Val797Gly) in Saudi Colorectal Cancer Patients: Potential Implications for Tumorigenesis. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Colorectal cancer (CRC) is a serious global health problem, ranking first in men and third in women among all cancers worldwide. The genetic basis for CRC remains unclear in most cases; therefore, the present study aimed to investigate the molecular genetic basis of CRC and correlate it with disease outcomes.
Rasool M, Haque A, Alharthi M, Ali T, Karim S, Mira LS, Al-Abbasi F, Aljiffry M, Ghunaim M, Sibiany A, Pushparaj PN.   +10 more
europepmc   +2 more sources

Historical review of Lynch syndrome

Journal of Coloproctology, 2013
Lynch syndrome was formerly known as Hereditary Nonpolyposis Colorectal Cancer. Currently, these two nomenclatures each have their unique definitions and are no longer used interchangeably.
Andrew I. Wolf, Adam H. Buchanan, Linda M. Farkas   +2 more
doaj   +1 more source

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts [PDF]

, 2013
Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2.
Sampson, JR, Capella, G., Moeslein, Gabriela, Moslein, G., Vasen, Hans F. A., Sijmons RH, Renkonen-Sinisalo, L, Genuardi, M, Engel, C., Leon, M., Møller P, Gopie, JP, Bertario, Lucio, Alonso A, Heinimann, K, Genuardi, M., Tejpar, S, Burn J, Rahner, N, Engel, Christoph, PONZ DE LEON, Maurizio, Alonso, A, Wijnen, J.T., Burn, John, Lindblom, Annika, Heinimann, Karl, Lindblom, A, Tejpar, Sabine, Vasen HF, Bertario L, Leon, M.P. de, Thomas HJ, Maurizio Genuardi., Nagengast, FM, Gopie JP, Myrhoj, T., Bernstein I, Hes, Frederik J., Stormorken, Astrid, Myrhoj, Torben, Aktan-Collan, Katja, Wijnen JT, Alonso, A., Tejpar, S., Hodgson, SV, Nagengast, Fokko M., Aretz, S., Vasen, H.F., Myrhoj T, Stormorken A, Moller, P., Engel C, Järvinen HJ, Sampson, Julian R., Karagiannis, JA, Mecklin, JP, Lalloo, F., Engel, C, Capella, G, Bernstein, I., Hodgson SV, Lindblom A, Bertario, L, Jaervinen, Heikki Juhani, Gopie, Jessica P., Karagiannis, John A., Burn, J, Karagiannis JA, Frayling, I.M., Sijmons, Rolf H., Sampson JR, Rahner, N., Ponz de Leon, M, Blanco, I, Aktan Collan K, Møller, P, Hes FJ, Aktan-Collan, K, Blanco, I., Genuardi, Maurizio, Aretz, Stefan, Vasen, HF, Blanco, Ignacio, Nagengast, F.M., Thomas, Huw J. W., Stormorken, A, Lindblom, A., Gopie, J.P., Bertario, L., Moller, Pal, Thomas, H.J.W., Lalloo, Fiona, Rahner N, Renkonen-Sinisalo, Laura, Wijnen, Juul T., Alonso, Angel, Sampson, Julian Roy, Bernstein, Inge, Sijmons, RH, Capella, Gabriel, Mallorca Grp, Jarvinen, H.J., Myrhoj, T, Hes, FJ, Aretz S, Järvinen, HJ, Wijnen, JT, Mallorca group, Vasen, H.F.A., Parc Y, Karagiannis, J.A., Bernstein, I, Hodgson, Shirley V., Rahner, Nils, et al., Parc, Y., Sampson, J.R., Aretz, S, Thomas, H.J., Frayling, Ian M., Capella G, Nagengast FM, Colas, C., Renkonen-Sinisalo, L., Tejpar S, Frayling, IM, Hes, F.J., Renkonen Sinisalo L, Frayling IM, Parc, Y, Mecklin, Jukka-Pekka, Möslein G., de Leon, Maurizio Ponz, Lalloo F, Blanco I, Möslein, G, Hodgson, S.V., Lalloo, F, Heinimann, K., Mecklin, J.P., Colas, C, Thomas, HJ, Colas, Chrystelle, Frayling, Ian Martin, Parc, Yann, Heinimann K, Burn, J., Sijmons, R.H., Stormorken, A., Genuardi M, de Leon, M.P., Colas C, Mecklin JP, Aktan-Collan, K.   +153 more
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Hereditary Colorectal Cancer in China

Hereditary Cancer in Clinical Practice, 2005
The purpose of this article is to review basic research as well as clinical studies on Chinese hereditary colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) accounts for 2.2% of all colorectal cancer, and Chinese ...
Shu Zheng, Yanqin Huang, Ying Yuan
doaj   +1 more source

A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer

Kaohsiung Journal of Medical Sciences, 2011
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant inherited disease predisposing to the development of colorectal cancers and several other malignancies (endometrium, ovaries, stomach, small bowel, hepatobiliary, and urinary ...
Wen-Chau Chen, Shao-Chieh Lin, Jenq-Chang Lee, 陳文超, 林劭潔, 李政昌   +5 more
doaj   +1 more source

Narrative review comparing the epidemiology, characteristics, and survival in sporadic colorectal carcinoma/Lynch syndrome

Journal of Coloproctology, 2020
Introduction: Colorectal carcinoma is the third most prevalent neoplasm in the world, and the second cause of death by cancer. The most part of these neoplasms are sporadic by somatic mutations, but around 15% are hereditary, such as Lynch syndrome or ...
Maria Beatriz de Matos, Laura Elisabete Barbosa, João Paulo Teixeira   +2 more
doaj   +1 more source

Association between TAS2R38 gene polymorphisms and colorectal cancer risk [PDF]

, 2011
Molecular sensing in the lingual mucosa and in the gastro-intestinal tract play a role in the detection of ingested harmful drugs and toxins. Therefore, genetic polymorphisms affecting the capability of initiating these responses may be critical for the ...
Stemmler, Susanne, Novotny, Jan, Steinke, Verena, Vodicka, Pavel, Morak, Monika, Hemminki, Kari, Pardini, Barbara, Engel, Christoph, Canzian, Federico, Schackert, Hans K., Naccarati, Alessio, Vodickova, Ludmila, Görgens, Heike, Propping, Peter, Barale, Roberto, Büttner, Reinhard, Försti, Asta, Carrai, Maura, Betz, Beate, Holinski-Feder, Elke, Stein, Angelika, Kloor, Matthias, Rahner, Nils, Campa, Daniele   +23 more
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Muir-Torre Syndrome: The Importance of a Detailed Family History

Case Reports in Ophthalmology, 2019
Muir-Torre syndrome, a variant of Lynch syndrome or hereditary nonpolyposis colorectal cancer, is an autosomal dominant disease characterized by skin neoplasms (sebaceous or keratoacanthomas) and visceral malignancies.
Christopher K.H. Burris, Maria E. Rodriguez, Meisha L. Raven, Devasis N. Reddy, Yaohui G. Xu, Janey L. Wiggs, Heather D. Potter, Daniel M. Albert   +7 more
doaj   +1 more source

Lynch syndrome: An unusal case of familial cancer unearthed

Indian Journal of Pathology and Microbiology, 2022
Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) is a type of inherited cancer syndrome with a genetic predisposition to different types of cancer.
Subhra Dhar, Ashraf U Mannan, J Jaya Singh, Sandipan Dhar, Swetalina Pradhan   +4 more
doaj   +1 more source