Results 61 to 70 of about 16,555 (261)

Quality of Life in Adult Individuals Living With or at Risk of a Hereditary Cancer Predisposition Syndrome: A Scoping Review of the Qualitative Literature

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background The in‐depth understanding of the impact of a hereditary cancer predisposition syndrome (HCPS) on the health‐related quality of life (HRQOL) of individuals with a hereditary cancer burden contributes to the improvement of counselling strategies as well as care planning and informs the development of patient‐reported outcome measures
M. Sztankay, S. Wheelwright, V. Vassiliou, E. M. A. Bleiker, B. Rahman, B. Holzner, A. Yener, V. Engele, A. S. Oberguggenberger, EORTC Quality of Life Group   +9 more
wiley   +1 more source

Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients

Journal of Experimental & Clinical Cancer Research, 2008
Background Patients with hereditary non-poliposys colorectal cancer (HNPCC) have better prognosis than sporadic colorectal cancer (CRC). Aim of our retrospective study was to compare the overall survival between sporadic CRC and HNPCC patients.
Mete Lupe, Mottolese Marcella, Giannarelli Diana, Palmirotta Raffaele, Cosimelli Maurizio, Assisi Daniela, Stigliano Vittoria, Mancini Raffaello, Casale Vincenzo   +8 more
doaj   +1 more source

Detection of Microsatellite Instability in Colorectal Cancer Patients With a Plasma-Based Real-Time PCR Analysis

Frontiers in Pharmacology, 2021
A microsatellite instability (MSI) test is crucial for screening for HNPCC (Hereditary nonpolyposis colorectal cancer; Lynch syndrome) and optimization of colorectal cancer (CRC) treatment.
Namjoo Kim, Sung Min Kim, Beom Jae Lee, Byung il Choi, Hee Sook Yoon, Sang Hee Kang, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Chungyeul Kim   +9 more
doaj   +1 more source

The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome [PDF]

, 2009
Germline mutations in the mismatch repair (MMR) genes are associated with Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC) syndrome.
A Ardern-Jones, A Brieger, A Menoyo, A Riccio, A Umar, B Quaresima, C Ban, C Ban, CD Heinen, CE Bronner, CJ Kim, D Kong, DE Lea, E Hoffmann, ER Hoffmann, FA Kadyrov, G Giannini, GM Li, H Shimodaira, H Tashiro, HF Vasen, HT Lynch, HT Tran, J D Virgo, J Huang, J Offman, J Trojan, K Heinimann, K Yoshikawa, KK Herfarth, L Dzantiev, M Clyne, M Nystrom-Lahti, M Radulovic, M Takahashi, MF Blasi, N Papadopoulos, NC Nicolaides, P Modrich, P Plevová, P Polaczek, PT Tran, PV Shcherbakova, R Eeles, R Kariola, RA Barnetson, RA Fishel, RA Reenan, RJ Scott, S Markowitz, S Shanley, V P C C Yu, Y Wang   +52 more
core   +6 more sources

Hereditary nonpolyposis colorectal cancer in endometrial cancer patients [PDF]

International Journal of Cancer, 2007
AbstractEndometrial cancer is the second most common cancer in hereditary nonpolyposis colorectal cancer (HNPCC). It has often been overlooked to explore the possibility of HNPCC in endometrial cancer patients. Our study was to investigate how many HNPCC patients existed among endometrial cancer patients.
Sang Nam, Yoon, Ja-Lok, Ku, Young-Kyoung, Shin, Kyung-Hee, Kim, Jin-Sung, Choi, Eun-Ja, Jang, Hyoung-Chul, Park, Duck-Woo, Kim, Min A, Kim, Woo Ho, Kim, Taek Sang, Lee, Jae Weon, Kim, Noh-Hyun, Park, Yong-Sang, Song, Soon-Beom, Kang, Hyo-Pyo, Lee, Seung-Yong, Jeong, Jae-Gahb, Park   +17 more
openaire   +2 more sources

Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels

BMC Medical Genetics, 2009
Background Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality.
Bendahl Pär-Ola, Carlsson Christina, Domanska Katarina, Nilbert Mef   +3 more
doaj   +1 more source

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]

, 2014
Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman, Araujo, Armitage, Baba, Bertagnolli, Curtis, Dhadda, Dhadda, Fadhil, Fadhil, Fearon, Fisher, Flyger, Fodde, Frei, Georgiades, Goh, Hadjihannas, Hawkins, Hedley, Heimann, Hutchins, Ilyas, Ingh, Jass, Karran, Kouri, Levitt, Lothe, Michelassi, Ormerod, Palles, Pino, Pritchard, Quirke, Rajagopalan, Ribic, Sieber, Silver, Suarez, Tang, The Cancer Genome Atlas Network, Thibodeau, Vecchio, Williams   +44 more
core   +2 more sources

Germline Cancer Susceptibility Variants in Patients With Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 38, Issue 5, September 2025.
Germline exome sequencing of 106 Finnish patients with UM, considered at higher risk for genetic cancer predisposition, identified pathogenic or likely pathogenic variants associated with varying risk of malignancies in 16 patients (15%). Six patients (6%) carried multiple variants and had a median diagnosis age of 51, compared to 60 in the full cohort
Pauliina E. Repo, Eveliina Jakkula, Juho Hiltunen, Heidi Putkuri, Aleksandra Staskiewicz‐Tuikkanen, Reetta‐Stiina Järvinen, Martin Täll, Virpi Raivio, Rana'a T. Al‐Jamal, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Attitudes Toward Updated Genetic Testing Among Patients with Unexplained Mismatch Repair Deficiency [PDF]

, 2018
Individuals who have colorectal cancer (CRC) or endometrial cancer (EC) displaying loss of immunohistochemical (IHC) staining of one or more mismatch repair (MMR) proteins without a causative germline mutation are said to have unexplained mismatch repair
Omark, Jessica
core   +1 more source

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source