Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. [PDF]
, 2002 KCNE genes encode single transmembrane-domain subunits, the MinK-related peptides (MiRPs), which assemble with pore-forming alpha subunits to establish the attributes of potassium channels in vivo.
Abbott, Geoffrey W, Goldstein, Steve AN
core +1 more source
Spin Properties of Supermassive Black Holes with Powerful Outflows
, 2016 Relationships between beam power and accretion disk luminosity are studied for a sample of 55 HERG, 13 LERG, and 29 RLQ with powerful outflows. The ratio of beam power to disk luminosity tends to be high for LERG, low for RLQ, and spans the full range of
Daly, Ruth A.
core +1 more source
Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
Journal of Pharmacological Sciences, 2008 Block of cardiac hERG K+ channels by the antihistamine terfenadine and the prokinetic agent cisapride is associated with prolonged ventricular repolarization and an increased risk of ventricular arrhythmia.
Kaichiro Kamiya +4 more
doaj +1 more source
Improving the hERG model fitting using a deep learning-based method [PDF]
, 2023 Jaekyung C. Song +2 more
openalex +1 more source
Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. [PDF]
, 2018 Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles.
Bekker, Slava +4 more
core
Solution structure of CnErg1 (Ergtoxin), a HERG specific scorpion toxin [PDF]
, 2003 Allan M. Torres +5 more
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Data in Brief, 2017 The data presented in this article are related to the research article entitled “The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr) and human ether-a-go-go-related gene (hERG) expression” (Y.F.
Yi Fan Teah +5 more
doaj +1 more source
, 2017 Blockage of some ion channels and in particular, the hERG cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrhythmia known as Torsade de Pointes (TdP).
Buzatu, Dan +3 more
core +1 more source
The Magnetic Field and Polarization Properties of Radio Galaxies in Different Accretion States
, 2015 We use the integrated polarized radio emission at 1.4 GHz ($\Pi_{\rm 1.4\,GHz}$) from a large sample of AGN (796 sources at redshifts ...
Banfield, J. K. +5 more
core +1 more source
Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain [PDF]
, 2016 Carol A. Harley +5 more
openalex +1 more source