Results 91 to 100 of about 33,807 (258)

A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). [PDF]

, 1998
MinK and MinK-related peptide I (MiRPI) are integral membrane peptides with a single transmembrane span. These peptides are active only when co-assembled with pore-forming K+ channel subunits and yet their role in normal ion channel behaviour is ...
Abbott, GW, Goldstein, SA
core  

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

The Magnetic Field and Polarization Properties of Radio Galaxies in Different Accretion States

, 2015
We use the integrated polarized radio emission at 1.4 GHz ($\Pi_{\rm 1.4\,GHz}$) from a large sample of AGN (796 sources at redshifts ...
Banfield, J. K., Farnes, J. S., Gaensler, B. M., Lara-López, M. A., O'Sullivan, Shane P., van Velzen, S.   +5 more
core   +1 more source

Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression

Scientific Reports, 2019
Impaired functional plasma membrane (PM) expression of the hERG K+-channel is associated with Long-QT syndrome type-2 (LQT2) and increased risk of cardiac arrhythmia. Reduced PM-expression is primarily attributed to retention and degradation of misfolded
Brian Foo, Camille Barbier, Kevin Guo, Jaminie Vasantharuban, G. Lukács, A. Shrier   +5 more
semanticscholar   +1 more source

Pyriproxyfen Disrupts the Ongoing Spermatogenesis Wave in Danio rerio Potentially Mediated by Voltage‐Dependent Calcium Channels and Protein Kinase C

Journal of Applied Toxicology, Volume 45, Issue 9, Page 1705-1719, September 2025.
ABSTRACT Pyriproxyfen (PPX) is an analog of the juvenile hormone from insects. Following our previous studies, for the ex vivo short‐term effect, we chose 10−9 M pyriproxyfen to analyze the morphology of spermatogenesis wave cells. In silico docking and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) studies were carried out to ...
Bruna Antunes Zaniboni, Vanessa Staldoni de Oliveira, Gabriel Adan Araujo Leite, Valdelúcia Maria Alves de Souza Grinevicius, Rozangela Curi Pedrosa, Fátima Regina Mena Barreto Silva   +5 more
wiley   +1 more source

An Insight into the Potassium Currents of hERG and Their Simulation

Molecules, 2023
By assuming that a stepwise outward movement of the four S4 segments of the hERG potassium channel determines a concomitant progressive increase in the flow of the permeant potassium ions, the inward and outward potassium currents can be simulated by using only one or two adjustable (i.e., free) parameters. This deterministic kinetic model differs from
openaire   +3 more sources

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, Volume 45, Issue 5, Page 1452-1465, September 2025.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Assessing the payback from health R & D: From ad hoc studies to regular monitoring [PDF]

, 2010
Chapter 1 : Introduction • The increasing demands for the benefits of payback from publicly funded R&D to be assessed are based partly on the need to justify or account for expenditure on R&D, and partly on the desire for information to assist resource ...
Buxton, MJ, Croxson, B, Hanney, S
core  

The Evolution of Radio Loud Active Galactic Nuclei as a Function of Black Hole Spin

, 2010
Recent work on the engines of active galactic nuclei jets suggests their power depends strongly and perhaps counter-intuitively on black hole spin. We explore the consequences of this on the radio-loud population of active galactic nuclei and find that ...
Allen, Antonuccio-Delogu, Barnes, Baum, Beloborodov, Benson, Berti, Bicknell, Blandford, Blandford, Blandford, Blum, Bogovalov, Brenneman, Bridle, Cao, D. A. Evans, D. Garofalo, Daly, Daly, De Young, Donato, Evans, Evans, Fabian, Fanaroff, Ferrarese, Garofalo, Garofalo, Gebhardt, Ghisellini, Gopal-Krishna, Grandi, Hardcastle, Hardcastle, Hardee, Heywood, Hughes, Kaiser, King, King, Kormendy, Kormendy, Kuncic, Kuncic, Magorrian, Mangalam, Marchesini, Marconi, McClintock, McKinney, McKinney, McKinney, McNamara, Meier, Meier, Meier, Miller, Moderski, Moderski, Nakamura, Narayan, Neilsen, Nemmen, Nesvadba, Novikov, O'Dea, Ogle, R. M. Sambruna, Rees, Reeves, Reeves, Reynolds, Reynolds, Reynolds, Sambruna, Smolcic, Smolcic, Tchekhovskoy, Tchekhovskoy, Thorne, Tremaine, Volonteri, Wilms, Wilson, Zoghbi   +85 more
core   +1 more source

Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon

International Journal of Molecular Sciences, 2019
Human ether a-go-go related gene (hERG) or KV11.1 potassium channels mediate the rapid delayed rectifier current (IKr) in cardiac myocytes. Drug-induced inhibition of hERG channels has been implicated in the development of acquired long QT syndrome type (
Saba Munawar, J. Vandenberg, Ishrat Jabeen   +2 more
semanticscholar   +1 more source