Results 81 to 90 of about 28,801 (226)

hERG Blockade by Iboga Alkaloids

Cardiovascular Toxicology, 2015
The iboga alkaloids are a class of naturally occurring and synthetic compounds, some of which modify drug self-administration and withdrawal in humans and preclinical models. Ibogaine, the prototypic iboga alkaloid that is utilized clinically to treat addictions, has been associated with QT prolongation, torsades de pointes and fatalities.
Alper, Kenneth, Bai, Rong, Liu, Nian, Fowler, Steven J., Huang, Xi Ping, Ruan, Yanfei, PRIORI, SILVIA GIULIANA   +6 more
openaire   +4 more sources

Position of Premature Termination Codons Determines Susceptibility of hERG Mutations to Nonsense-Mediated mRNA Decay in Long QT Syndrome

, 2014
The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2).
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +1 more source

Modeling HERG Isoforms [PDF]

Biophysical Journal, 2013
The delayed rectifier, IKr, is formed by homo/heterotetramers of the 2 HERG splice variants HERG1a and HERG1b. The only difference between isoforms is that HERG1b has a shorter N-terminal than HERG1a. Despite their similarities, HERG1a and 1b have profoundly different gating kinetics: HERG1b has faster activation and deactivation kinetics than HERG1a ...
Zhou, Qinlian, Lis, Agnieszka, Bett, G.
openaire   +1 more source

The isolated working guinea pig heart: A functional and electrophysiological characterisation

Experimental Physiology, EarlyView.
Abstract Small animal isolated perfused hearts have been used for over 150 years for the study of cardiac physiology and pharmacology. The guinea pig heart represents the smallest mammalian heart that replicates key features of the human heart – for example, with respect to cardiac action potential duration, ion channel expression, excitation ...
Grace C. Anderson‐Barker, Michael J Shattock   +1 more
wiley   +1 more source

Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

, 2014
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11 ...
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities

Frontiers in Pharmacology, 2018
The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes ...
Saba Munawar, Saba Munawar, Monique J. Windley, Edwin G. Tse, Matthew H. Todd, Adam P. Hill, Jamie I. Vandenberg, Ishrat Jabeen   +7 more
doaj   +1 more source

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. [PDF]

, 2018
Interactions of drug molecules with lipid membranes play crucial role in their accessibility of cellular targets and can be an important predictor of their therapeutic and safety profiles.
Bekker, Slava, Clancy, Colleen E, DeMarco, Kevin R, Noskov, Sergei Y, Vorobyov, Igor   +4 more
core  

Conducting retrospective impact analysis to inform a medical research charity’s funding strategies: The case of Asthma UK [PDF]

, 2013
© 2013 Hanney et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Amanda Watt, AR Jadad, British Thoracic Society and Scottish Intercollegiate Guidelines Network, British Thoracic Society Scottish Intercollegiate Guidelines Network, Canadian Academy of Medical Sciences, CE Brightling, D Cooksey, E Nason, E Xystrakis, GK Scadding, House of Lords Science and Technology Committee, J Bott, LA Laitinen, LB Bacharier, Leanne Metcalf, LJ Tata, M Buxton, M Buxton, M Thomas, MA Berry, National Institute for Health Research, P Adam, PA Wark, PE Christie, PE Christie, PJ Jose, PM O’Byrne, PV Dicpinigaitis, R Banzi, R Smith, S Hanney, S Hanney, S Hanney, S Hanney, S Saglani, S Walker, S Wooding, SR Durham, Stephen R Hanney, T Pang, Teresa H Jones, TH Lee, UK Evaluation Forum, WJ Oortwijn, WL Oldfield   +44 more
core   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source