Results 61 to 70 of about 5,479 (195)

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Global analysis reveals families of chemical motifs enriched for HERG inhibitors.

PLoS ONE, 2015
Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals.
Fang Du, Joseph J Babcock, Haibo Yu, Beiyan Zou, Min Li   +4 more
doaj   +1 more source

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. [PDF]

PLoS ONE, 2015
Human Ether á go-go Related Gene potassium channels form the rapid component of the delayed-rectifier (IKr) current in the heart. The N-terminal 'eag' domain, which is composed of a Per-Arnt-Sim (PAS) domain and a short PAS-cap region, is a critical ...
Qiang-Ni Liu, Matthew C Trudeau
doaj   +1 more source

Analysis of hERG protein expression in HEK293 cells.

, 2013
a. Representative protein expression of untreated WT-hERG, WT/E637K-hERG, and E637K-hERG channels. b–d. Representative protein expression of WT-hERG, WT/E637K-hERG and E637K-hERG channels treated with 1 uM thapsigargin for 24 h to 48 h, respectively ...
Justin Michael Karush (423498), Ningsheng Liu (335951), Xiaoyan Huang (112885), Yanna Ba (112883), Jiangfang Lian (112879), Xiaoli Lu (423497), Jianqing Zhou (112889), Ying Wang (11406), Haiyan Mao (335948), Xi Yang (112884)   +9 more
core   +1 more source

Biological Effects of Selenium‐Containing Ionic Liquids: Cytotoxicity, Mercury Interaction, and Antiproliferative Activity in Glioblastoma Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder, Alessandro de Souza Prestes, Fernanda D'Avila da Silva, Nilda de Vargas Barbosa, Alix Y. Bastidas Ángel, Mariana F. Soares, Carolina Martins Fernandes, Maria Anttônia Oliveira Petersen, Manuela Moura Silva, Juliete Nathali Scholl, Fabrício Figueiró, Pablo Andrei Nogara, Laura Orian, Eduardo E. Alberto, Michael Aschner, Diogo Onofre Gomes de Souza, Debora Guerini de Souza, João Batista Teixeira da Rocha   +17 more
wiley   +1 more source

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

PLoS ONE, 2019
The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines.
Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri   +5 more
doaj   +1 more source

Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. [PDF]

PLoS ONE, 2015
Tannic acid presents in varying concentrations in plant foods, and in relatively high concentrations in green teas and red wines. Human ether-à-go-go-related gene (hERG) channels expressed in multiple tissues (e.g.
Xi Chu, Yusong Guo, Bingyuan Xu, Wenya Li, Yue Lin, Xiaorun Sun, Chunhua Ding, Xuan Zhang   +7 more
doaj   +1 more source

Computational prediction of hERG blockers using homology modelling, molecular docking and QuaSAR studies

Results in Chemistry, 2021
A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
doaj   +1 more source

hERG Blockade by Iboga Alkaloids

Cardiovascular Toxicology, 2015
The iboga alkaloids are a class of naturally occurring and synthetic compounds, some of which modify drug self-administration and withdrawal in humans and preclinical models. Ibogaine, the prototypic iboga alkaloid that is utilized clinically to treat addictions, has been associated with QT prolongation, torsades de pointes and fatalities.
Alper, Kenneth, Bai, Rong, Liu, Nian, Fowler, Steven J., Huang, Xi Ping, Ruan, Yanfei, PRIORI, SILVIA GIULIANA   +6 more
openaire   +4 more sources

Surface density of HA-hERG containing channels.

, 2013
(A) Schematic of the transmembrane topology of the hERG subunit illustrating the insertion site of the HA sequence. (B) HEK-MSR cells were transfected with various ratios of HA-hERG and hERG expression vectors.
Rucha Karnik (504688), Matthew E. L. Hardy (504691), Asipu Sivaprasadarao (504693), Melanie J. Ludlow (504689), Nada Abuarab (504690), David J. S. Elliott (504692), Andrew J. Smith (235407)   +6 more
core   +1 more source