Results 61 to 70 of about 28,801 (226)

Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database [PDF]

, 2013
Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US ...
A Bate, A Clarke, A Pariente, AK Chung, Ariola Koci, B Darpo, BJ Drew, C Meyer-Massetti, DM Roden, DW Hough, E Poluzzi, E Poluzzi, E Poluzzi, E Raschi, E Raschi, Edoardo Spina, Elijah R. Behr, Elisabetta Poluzzi, Emanuel Raschi, EP Puijenbroek van, ER Behr, F Ponti De, F Ponti De, F Rani, Fabrizio De Ponti, GC Alexander, GK Isbister, H Verdoux, J Nielsen, J Papay, K Jolly, K Titier, LC Wittkampf, LS Schneider, Miriam Sturkenboom, NP Tatonetti, P Kannankeril, P Manu, P Vigneault, RC Owens Jr, RR Shah, S Dhillon, S Hennessy, S Kongsamut, S Leucht, SM Straus, Ugo Moretti, W Crumb, W Crumb, WA Ray, WA Ray, WJ Crumb Jr, WP Stephenson, Y Suzuki   +53 more
core   +4 more sources

Effects of cariprazine on hERG 1A and hERG 1A/3.1 potassium channels

European Journal of Pharmacology, 2019
Cariprazine is a novel atypical antipsychotic drug that is widely used for the treatment of schizophrenia and bipolar mania/mixed disorder. We used the whole-cell patch-clamp technique to investigate the effects of cariprazine on hERG channels that are stably expressed in HEK cells. Cariprazine inhibited the hERG 1A and hERG 1A/3.1 tail currents at -50
Hong Joon, Lee, Bok Hee, Choi, Jin-Sung, Choi, Sang June, Hahn   +3 more
openaire   +2 more sources

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Analysis and prediction of injury severity in single micromobility crashes with Random Forest

Heliyon, 2023
Urban micromobility represents a significant shift towards sustainable cities, underscoring the paramount importance of its safety. With the surge in micromobility adoption, collisions involving micromobility devices, such as bicycles and e-scooters ...
Almudena Sanjurjo-de-No, Ana María Pérez-Zuriaga, Alfredo García   +2 more
doaj   +1 more source

Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). [PDF]

, 2001
Voltage-gated potassium channels provide tightly Controlled, ion-specific pathways across membranes and are key to the normal function of nerves muscles. They arise from the assembly of four pore-forming proteins called alpha-subunits.
Abbott, GW, Goldstein, SA
core  

An orientation-based unification of young jetted AGN: the case of 3C 286 [PDF]

, 2017
In recent years, the old paradigm according to which only high-mass black holes can launch powerful relativistic jets in active galactic nuclei (AGN) has begun to crumble. The discovery of $\gamma$-rays coming from narrow-line Seyfert 1 galaxies (NLS1s),
Alessandro Caccianiga, Enrico Congiu, Enrico Congiu, Giovanni La Mura, Luigi Foschini, Marco Berton, Marco Berton, Michele Frezzato, Piero Rafanelli, Stefano Ciroi, Valentina Cracco   +10 more
core   +3 more sources

Feathers and flu: identifying data gaps in avian influenza host dynamics to prioritize wildlife conservation Plumas y gripe: identificación de datos faltantes en la dinámica de hospedadores de la influenza aviar para priorizar la conservación de la vida silvestre

Wildlife Monographs, EarlyView.
We describe the host response continuum for highly pathogenic avian influenza viruses (HPAIV), including the continuum of host responses to HPAIV infection and exposure based on the primary axis of host competence, ability to infect other hosts, and host vulnerability.
Johanna A. Harvey, Matthew Gonnerman, Shenglai Yin, Cody M. Kent, Joshua Cullen, Jeffery D. Sullivan, Jonathan B. Dain, Nichola J. Hill, Diann J. Prosser, Jennifer M. Mullinax   +9 more
wiley   +1 more source

Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts

Journal of Pharmacological Sciences, 2013
In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K+ channel have been associated with development of fatal arrhythmias. This implies that drugs that activate hERG as a side effect may likewise pose
Mahoko Asayama, Junko Kurokawa, Kiyoshi Shirakawa, Hisashi Okuyama, Toshiki Kagawa, Jun-ichi Okada, Seiryo Sugiura, Toshiaki Hisada, Tetsushi Furukawa   +8 more
doaj   +1 more source

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue

Pharmaceuticals, 2023
hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell, Yihong Zhang, Aziza El Harchi, Christopher E. Dempsey, Jules C. Hancox   +4 more
doaj   +1 more source

A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). [PDF]

, 1998
MinK and MinK-related peptide I (MiRPI) are integral membrane peptides with a single transmembrane span. These peptides are active only when co-assembled with pore-forming K+ channel subunits and yet their role in normal ion channel behaviour is ...
Abbott, GW, Goldstein, SA
core