Results 51 to 60 of about 5,479 (195)
British Journal of Clinical Pharmacology, EarlyView.. Aims Traditional pharmacovigilance detects single drug–event associations but cannot readily characterize multi‐system adverse‐event patterns such as fluoroquinolone‐associated disability. We evaluated unsupervised machine learning for this purpose, using fluoroquinolones as an exemplar.
Niaz Chalabianloo +3 more
wiley +1 more source
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. [PDF]
PLoS ONE, 2013 The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear.The hERG potassium channel blockage by a new 36-residue scorpion ...
Jian Ma +5 more
doaj +1 more source
Klotho sensitivity of the hERG channel
FEBS Letters, 2013 Klotho, a hormone and enzyme, is a powerful regulator of ageing and life span. Klotho deficiency leads to cardiac arrythmia and sudden cardiac death. We thus explored whether klotho modifies cardiac K+‐channel hERG. Current was determined utilizing dual electrode voltage clamp and hERG protein abundance utilizing immunohistochemistry and ...
Munoz, Carlos +8 more
openaire +3 more sources
Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A [PDF]
British Journal of Anaesthesia, 2004 Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established.
P, Friederich +3 more
openaire +2 more sources
Degradation of G572R-hERG and E637K-hERG mutant channels through ubiquitin-proteasome pathway.
, 2013 a, HEK293 cells were transfected with WT-hERG, G572R-hERG or E637K-hERG plasmid and then treated with 20 uM lactacystin (LACT), 50 uM ALLN or 100 uM leupeptin (LEUP) for 24 hours.
Huan Huan Sun (335949) +8 more
core +1 more source
European Journal of Inorganic Chemistry, EarlyView.Rollover cyclometalation is a distinctive variant of classical cyclometalation where a chelated heterocyclic ligand undergoes internal rotation, releasing one donor atom from coordination and subsequently activating a remote C─H bond with high regioselectivity.
Antonio Zucca, Maria I. Pilo
wiley +1 more source
Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts
Journal of Pharmacological Sciences, 2013 In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K+ channel have been associated with development of fatal arrhythmias. This implies that drugs that activate hERG as a side effect may likewise pose
Mahoko Asayama +8 more
doaj +1 more source
Food Chemistry International, EarlyView.The graphical abstract represents how natural plant products that preferentially target the specific receptors of quorum sensing could be developed to combat biofilms linked to Yersinia enterocolitica using the potent abilities of protein–ligand complexes with high docking scores.
Rajendran Thomas +7 more
wiley +1 more source
HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia
Journal of Diabetes Research, 2016 The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry.
Hai-Yan Qiu +4 more
doaj +1 more source
Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
Pharmaceuticals, 2023 hERG (human Ether-à-go-go Related Gene)-encoded potassium channels underlie the cardiac rapid delayed rectifier (IKr) potassium current, which is a major target for antiarrhythmic agents and diverse non-cardiac drugs linked to the drug-induced form of ...
Matthew V. Helliwell +4 more
doaj +1 more source