Results 41 to 50 of about 28,801 (226)
, 2012 Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K+ channel that contributes to the repolarization of the cardiac action potential.
Gong, Qiuming +3 more
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Antipsychotics, HERG and sudden death [PDF]
British Journal of Psychiatry, 2003 The recent case—control study by Reilly et al ([2002][1]) showing an association between probable sudden unexplained death and current treatment with thioridazine in psychiatric in-patients underscores two fundamental issues essential for dealing with potential risks of this kind in the context ...
H J, Witchel +3 more
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Gain of function mutants: Ion channels and G protein-coupled receptors [PDF]
, 2000 Many ion channels and receptors display striking phenotypes for gain-of-function mutations but milder phenotypes for null mutations. Gain of molecular function can have several mechanistic bases: selectivity changes, gating changes including constitutive
Karschin, Andreas, Lester, Henry A.
core +1 more source
Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T [PDF]
Jichu yixue yu linchuang, 2021 Objective To investigate the role of Rer1 in hERG potassium channel protein transport,and to study the medicine Baf A1 that may restore abnormal hERG transport.
CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun
doaj
Stimulation of HERG channel activity by β-catenin. [PDF]
PLoS ONE, 2012 The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival.
Carlos Munoz +7 more
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Hierarchical Cont-Bouchaud model [PDF]
, 2015 We extend the well-known Cont-Bouchaud model to include a hierarchical topology of agent's interactions. The influence of hierarchy on system dynamics is investigated by two models. The first one is based on a multi-level, nested Erdos-Renyi random graph
Holyst, Janusz A. +2 more
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BMC Molecular and Cell Biology, 2021 Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura +14 more
doaj +1 more source
Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]
, 2008 MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan +5 more
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Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]
, 2019 Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan +6 more
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Kv4.3 Modulates the Distribution of hERG [PDF]
Scientific Reports, 2017 AbstractThis study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3, expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence, and co-immunoprecipitation.
Zhao, Xiao-Jing +7 more
openaire +2 more sources