Results 41 to 50 of about 5,479 (195)
Confocal imaging of WT-hERG and G572R-hERG/E637K-hERG channels in U2OS cells.
, 2013 U2OS cells were transfected with WT-hERG, G572R-hERG and E637K-hERG plasmids and co-stained with anti-hERG (green) and anti-Calnexin or anti-Calreticulin (red) antibodies, as indicated. Calnexin and Calreticulin localize to the ER (top row) while WT-hERG
Huan Huan Sun (335949) +8 more
core +1 more source
Stimulation of HERG channel activity by β-catenin. [PDF]
PLoS ONE, 2012 The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety of genes relevant for cell proliferation and cell survival.
Carlos Munoz +7 more
doaj +1 more source
Advanced Science, EarlyView.Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler +4 more
wiley +1 more source
Antipsychotics, HERG and sudden death [PDF]
British Journal of Psychiatry, 2003 The recent case—control study by Reilly et al ([2002][1]) showing an association between probable sudden unexplained death and current treatment with thioridazine in psychiatric in-patients underscores two fundamental issues essential for dealing with potential risks of this kind in the context ...
H J, Witchel +3 more
openaire +2 more sources
Comparative Analysis of Model‐Agnostic Explanation Methods in Materials Science
Advanced Intelligent Systems, EarlyView.To address the critical lack of explainable artificial intelligence (XAI) benchmarks in materials science, we present a quantitative and qualitative analysis of six XAI methods applied to molecular fingerprints. Our results reveal significant discrepancies in feature importance rankings, demonstrating that the chosen explanation approach introduces ...
Anna Przybyłowska +7 more
wiley +1 more source
Methods to estimate the cost effectiveness threshold for the NHS [PDF]
, 2011 This presentation was delivered by Professor Mark Sculpher from the University of York, UK on 6th September 2011, as part of the HERG Seminar Series.
HERG Seminar Series, Sculpher, M
core +5 more sources
Effects of cariprazine on hERG 1A and hERG 1A/3.1 potassium channels
European Journal of Pharmacology, 2019 Cariprazine is a novel atypical antipsychotic drug that is widely used for the treatment of schizophrenia and bipolar mania/mixed disorder. We used the whole-cell patch-clamp technique to investigate the effects of cariprazine on hERG channels that are stably expressed in HEK cells. Cariprazine inhibited the hERG 1A and hERG 1A/3.1 tail currents at -50
Hong Joon, Lee +3 more
openaire +2 more sources
Nahinfrarot‐Photoschalten durch direkte Anregung—die nächste Herausforderung
Angewandte Chemie, EarlyView.Molekulare Photoschalter können endlich direkt mit Licht aus dem Nahinfrarotbereich angeregt werden. Dieser Kurzaufsatz fasst den derzeitigen Entwicklungsstand, die Designprinzipien für niedrigenergetische Lichtresponsivität und die dadurch möglichen außergewöhnlichen Anwendungen zusammen.
Diptiprava Sahoo +2 more
wiley +1 more source
Proteasome inhibition increases association of G572R-hERG/E637K-hERG with Calnexin/Calreticulin.
, 2013 HEK293 cells were transfected with WT-hERG, G572R-hERG or E637K-hERG plasmid. Cells were then treated with proteasome inhibitors and immunoprecipitated with anti-Calnexin or anti-Calreticulin antibody and immunoblotted with anti-hERG antibody.
Huan Huan Sun (335949) +8 more
core +1 more source