Results 21 to 30 of about 5,479 (195)

miRNAs Regulate hERG [PDF]

Journal of Cardiovascular Electrophysiology, 2016
miRNAs Regulate hERGBackgroundThe human ether‐a‐go‐go‐related gene (hERG) is the major molecular component of the rapidly activating delayed rectifier K+ current (Ikr). Impairment of hERG function is believed to be a mechanism causing long‐QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of
Jiangfang, Lian, Jian, Guo, Xiaoyan, Huang, X I, Yang, Guochang, Huang, Haiyan, Mao, Huan Huan, Sun, Yanna, Ba, Jianqing, Zhou   +8 more
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Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome [PDF]

, 2011
The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death.
Hancox Jules C., McPate, Mark J., Mark J McPate, Hancox, Jules C., Witchel, HJ, Witchel Harry J., Witchel, Harry J., Ismail Adeniran, Zhang, H., Hancox, JC, McPate, MJW, Henggui Zhang (74233), Ismail Adeniran (192479), Adeniran, I., Adeniran, Ismail, Zhang Henggui, Adeniran Ismail, Zhang, Henggui, Henggui Zhang, Jules C Hancox, Harry Witchel (4462174), Jules C Hancox (16149998), McPate Mark J., Mark J McPate (16150001), Harry J Witchel   +24 more
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Investigation of the Influence of hERG 1b on hERG Channel Pharmacology [PDF]

Biophysical Journal, 2013
hERG channels mediating the rapid delayed rectifier K+ current (IKr) are important for normal ventricular repolarization. In native cardiac tissues, hERG 1a subunit co-assembles with a subunit encoded by an alternate transcript, “ERG1b” which has a shorter N-terminus (1) and influences current kinetics (2).
El Harchi, Aziza, Melgari, Dario, Hancox, Jules C.   +2 more
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In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details

Frontiers in Physiology, 2017
Acquired long QT syndrome, mostly as a result of drug block of the Kv11. 1 potassium channel in the heart, is characterized by delayed cardiac myocyte repolarization, prolongation of the T interval on the ECG, syncope and sudden cardiac death due to the ...
William Lee, William Lee, Monique J. Windley, Monique J. Windley, Jamie I. Vandenberg, Jamie I. Vandenberg, Adam P. Hill, Adam P. Hill   +7 more
doaj   +1 more source

hERG Function in Light of Structure [PDF]

Biophysical Journal, 2020
The human ether-a-go-go-related gene1 (hERG) ion channel has been the subject of fascination since it was identified as a target of long QT syndrome more than 20 years ago. In this Biophysical Perspective, we look at what makes hERG intriguing and vexingly unique. By probing recent high-resolution structures in the context of functional and biochemical
Gail A, Robertson, João H, Morais-Cabral   +1 more
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Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1

Journal of Arrhythmia, 2016
Background: The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2).
Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto   +21 more
doaj   +1 more source

HPLC-based activity profiling for pharmacologically and toxicologically relevant natural products – principles and recent examples

Pharmaceutical Biology, 2019
Context: Discovery of pharmacologically active natural products as starting points for drug development remains important and, for reasons of consumer safety, the identification of toxicologically relevant compounds in herbal drugs. Objective: To explain,
Matthias Hamburger
doaj   +1 more source

NBD-Based Environment-Sensitive Fluorescent Probes for the Human Ether-a-Go-Go–Related Gene Potassium Channel

Frontiers in Molecular Biosciences, 2021
Three environment-sensitive probes were developed for the hERG channel based on the nitrobenzoxadiazole fluorophore herein. After careful evaluation, probes M1 and M3 were found to have a high affinity for imaging the hERG channel in the cell-based ...
Qi Li, Lijuan Chai, Gaopan Dong, Xiaomeng Zhang, Lupei Du   +4 more
doaj   +1 more source

The electric heart of hERG [PDF]

Journal of General Physiology, 2013
Potassium channels encoded by the human ether-a-go-go–related gene (hERG) are of crucial importance for the repolarization of the cardiac action potential, as they constitute the main component of the cardiac delayed rectifier current, IKr ([Sanguinetti et al., 1995][1]).
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Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

Cellular Physiology and Biochemistry, 2014
Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted by various pro-arrhythmic drugs.
Kaiping Zhang, Duo Zhi, Ting Huang, Yan Gong, Meng Yan, Chen Liu, Ting Wei, Zengxiang Dong, Baoxin Li, Baofeng Yang   +9 more
doaj   +1 more source