Results 11 to 20 of about 28,801 (226)

PIKfyve Sensitivity of hERG Channels [PDF]

Cellular Physiology and Biochemistry, 2013
Background/Aims: Human ether-a-go-go (hERG) channels contribute to cardiac repolarization and participate in the regulation of tumor cell proliferation.
Tatsiana Pakladok, Ahmad Almilaji, Carlos Munoz, Ioana Alesutan, Florian Lang   +4 more
doaj   +3 more sources

Models of HERG Gating [PDF]

Biophysical Journal, 2011
HERG (Kv11.1, KCNH2) is a voltage-gated potassium channel with unique gating characteristics. HERG has fast voltage-dependent inactivation, relatively slow deactivation, and fast recovery from inactivation. This combination of gating kinetics makes study of HERG difficult without using mathematical models.
Bett, Glenna C.L., Zhou, Qinlian, Rasmusson, Randall L.   +2 more
openaire   +2 more sources

Homozygous Premature Truncation of the HERG Protein [PDF]

Circulation, 1999
Background —In long-QT syndrome (LQTS), heterozygosity for a mutation in 1 of the K + channel genes leads to prolongation of the cardiac action potential, because the aberrant protein exhibits “loss of function.” HERG, which is involved in LQT2, is the gene encoding the rapid component of the delayed ...
Hoorntje, T., Alders, M., van Tintelen, P., van der Lip, K., Sreeram, N., van der Wal, A., Mannens, M., Wilde, A.   +7 more
openaire   +4 more sources

miRNAs Regulate hERG [PDF]

Journal of Cardiovascular Electrophysiology, 2016
miRNAs Regulate hERGBackgroundThe human ether‐a‐go‐go‐related gene (hERG) is the major molecular component of the rapidly activating delayed rectifier K+ current (Ikr). Impairment of hERG function is believed to be a mechanism causing long‐QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of
Jiangfang, Lian, Jian, Guo, Xiaoyan, Huang, X I, Yang, Guochang, Huang, Haiyan, Mao, Huan Huan, Sun, Yanna, Ba, Jianqing, Zhou   +8 more
openaire   +2 more sources

hERG Function in Light of Structure [PDF]

Biophysical Journal, 2020
The human ether-a-go-go-related gene1 (hERG) ion channel has been the subject of fascination since it was identified as a target of long QT syndrome more than 20 years ago. In this Biophysical Perspective, we look at what makes hERG intriguing and vexingly unique. By probing recent high-resolution structures in the context of functional and biochemical
Gail A, Robertson, João H, Morais-Cabral   +1 more
openaire   +2 more sources

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum. [PDF]

PLoS ONE, 2012
Long QT syndrome type 2 (LQT2) is the second most common type of all long QT syndromes. It is well-known that trafficking deficient mutant human ether-a-go-go-related gene (hERG) proteins are often involved in LQT2.
Ying Wang, Xiaoyan Huang, Jianqing Zhou, Xi Yang, Di Li, Haiyan Mao, Huan Huan Sun, Ningsheng Liu, Jiangfang Lian   +8 more
doaj   +1 more source

Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel.

PLoS ONE, 2012
BackgroundThe familial Short QT Syndrome (SQTS) is associated with an increased risk of cardiac arrhythmia and sudden death. Gain-of-function mutations in the hERG K(+) channel protein have been linked to variant 1 of the SQTS. A hERG channel pore (T618I)
Aziza El Harchi, Dario Melgari, Yi Hong Zhang, Henggui Zhang, Jules C Hancox   +4 more
doaj   +1 more source

Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups [PDF]

, 2012
he design and synthesis of a new class of minor groove binder (MGBs) in which, the cationic tail group has been replaced by a neutral, polar variant including cyanoguanidine, nitroalkene, and trifluoroacetamide groups.
Bourdin, Claire, Breen, David, Clements, Carol, Donoghue, Gavin, Fox, Keith, Khalaf, Abedawn, MacMillan, Donna, Scott, Fraser, Sekibo, Doreen, Suckling, Colin   +9 more
core   +1 more source

The triggering probability of radio-loud AGN: A comparison of high and low excitation radio galaxies in hosts of different colors [PDF]

, 2012
Low luminosity radio-loud active galactic nuclei (AGN) are generally found in massive red elliptical galaxies, where they are thought to be powered through gas accretion from their surrounding hot halos in a radiatively inefficient manner.
Abazajian, Baldwin, Balogh, Becker, Best, Best, Best, Best, Brinchmann, Condon, Croton, Evans, H. J. A. Röttgering, Hardcastle, Hickox, J. Brinchmann, Kauffmann, Kauffmann, Kauffmann, Martin, Matthews, P. N. Best, R. M. J. Janssen, Schmidt, Stoughton, Strateva, Strauss, Tadhunter, Tasse, Whysong, York   +30 more
core   +3 more sources

Investigation of the Influence of hERG 1b on hERG Channel Pharmacology [PDF]

Biophysical Journal, 2013
hERG channels mediating the rapid delayed rectifier K+ current (IKr) are important for normal ventricular repolarization. In native cardiac tissues, hERG 1a subunit co-assembles with a subunit encoded by an alternate transcript, “ERG1b” which has a shorter N-terminus (1) and influences current kinetics (2).
El Harchi, Aziza, Melgari, Dario, Hancox, Jules C.   +2 more
openaire   +1 more source