Results 11 to 20 of about 5,479 (195)

PIKfyve Sensitivity of hERG Channels [PDF]

Cellular Physiology and Biochemistry, 2013
Background/Aims: Human ether-a-go-go (hERG) channels contribute to cardiac repolarization and participate in the regulation of tumor cell proliferation.
Tatsiana Pakladok, Ahmad Almilaji, Carlos Munoz, Ioana Alesutan, Florian Lang   +4 more
doaj   +4 more sources

hERG database

, 2022
hERG database for classification united = ChEMBL + hERG ...
Elina Shaniazova
core   +4 more sources

An Update on the Structure of hERG [PDF]

Frontiers in Pharmacology, 2020
The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action potential repolarization, effectively controlling the QT interval of the electrocardiogram.
Andrew Butler, Matthew V. Helliwell, Yihong Zhang, Jules C. Hancox, Christopher E. Dempsey   +4 more
doaj   +5 more sources

High Glucose Represses hERG K+ Channel Expression through Trafficking Inhibition

Cellular Physiology and Biochemistry, 2015
Background/Aims: Abnormal QT prolongation is the most prominent cardiac electrical disturbance in patients with diabetes mellitus (DM). It is well known that the human ether-ago-go-related gene (hERG) controls the rapid delayed rectifier K+ current (IKr)
Yuan-Qi Shi, Meng Yan, Li-Rong Liu, Xiao Zhang, Xue Wang, Huai-Ze Geng, Xin Zhao, Bao-Xin Li   +7 more
doaj   +2 more sources

Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells

Journal of Arrhythmia, 2017
Background: Pilsicainide, classified as a relatively selective Na+ channel blocker, also has an inhibitory action on the rapidly-activating delayed-rectifier K+ current (IKr) through human ether-a-go-go-related gene (hERG) channels.
Takeshi Onohara, MD, Ichiro Hisatome, MD, Yasutaka Kurata, MD, Peili Li, MD, Tomomi Notsu, PhD, Kumi Morikawa, PhD, Naoyuki Otani, MD, Akio Yoshida, MD, Kazuhiko Iitsuka, MD, Masaru Kato, MD, Junichiro Miake, MD, Haruaki Ninomiya, MD, Katsumi Higaki, PhD, Yasuaki Shirayoshi, PhD, Takashi Nishihara, BE, Toshiyuki Itoh, PhD, Yoshinobu Nakamura, MD, Motonobu Nishimura, MD   +17 more
doaj   +2 more sources

Kv4.3 Modulates the Distribution of hERG [PDF]

Scientific Reports, 2017
AbstractThis study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3, expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence, and co-immunoprecipitation.
Zhao, Xiao-Jing, Zhu, Chao, Tian, Liu-Yang, Fu, Yi-Cheng, Zhang, Yu, Chen, Xi, Huang, Yun, Li, Yang   +7 more
openaire   +3 more sources

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency

Drug Design, Development and Therapy, 2015
Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX   +5 more
doaj   +1 more source

LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency [PDF]

Drug Design, Development and Therapy
Caichuan Yan,* Yuexin Li,* Xiaoxu Li, Yang Li, Yuhao Zhang, Jinyang Sun, Qirui Ding, Xin Zhao, Baoxin Li Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, People’s Republic of China*These authors contributed ...
Yan C, Li Y, Li X, Li Y, Zhang Y, Sun J, Ding Q, Zhao X, Li B   +8 more
doaj   +1 more source

Models of HERG Gating [PDF]

Biophysical Journal, 2011
HERG (Kv11.1, KCNH2) is a voltage-gated potassium channel with unique gating characteristics. HERG has fast voltage-dependent inactivation, relatively slow deactivation, and fast recovery from inactivation. This combination of gating kinetics makes study of HERG difficult without using mathematical models.
Bett, Glenna C.L., Zhou, Qinlian, Rasmusson, Randall L.   +2 more
openaire   +2 more sources

Homozygous Premature Truncation of the HERG Protein [PDF]

Circulation, 1999
Background —In long-QT syndrome (LQTS), heterozygosity for a mutation in 1 of the K + channel genes leads to prolongation of the cardiac action potential, because the aberrant protein exhibits “loss of function.” HERG, which is involved in LQT2, is the gene encoding the rapid component of the delayed ...
Hoorntje, T., Alders, M., van Tintelen, P., van der Lip, K., Sreeram, N., van der Wal, A., Mannens, M., Wilde, A.   +7 more
openaire   +4 more sources