Results 31 to 40 of about 5,479 (195)

Structural modeling of the hERG potassium channel and associated drug interactions

Frontiers in Pharmacology, 2022
The voltage-gated potassium channel, KV11.1, encoded by the human Ether-à-go-go-Related Gene (hERG), is expressed in cardiac myocytes, where it is crucial for the membrane repolarization of the action potential.
Jan Maly, Jan Maly, Aiyana M. Emigh, Aiyana M. Emigh, Kevin R. DeMarco, Kevin R. DeMarco, Kazuharu Furutani, Jon T. Sack, Colleen E. Clancy, Colleen E. Clancy, Igor Vorobyov, Igor Vorobyov, Vladimir Yarov-Yarovoy   +12 more
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Structural modeling of hERG channel–drug interactions using Rosetta

Frontiers in Pharmacology, 2023
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez, Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kevin R. DeMarco, Kazuharu Furutani, Kazuharu Furutani, Slava Bekker, Slava Bekker, Jon T. Sack, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Colleen E. Clancy, Colleen E. Clancy, Igor Vorobyov, Igor Vorobyov, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +17 more
doaj   +1 more source

Analysis of a Driving Simulator’s Steering System for the Evaluation of Autonomous Vehicle Driving

Sensors
The integration of autonomous vehicles (AVs) into road transport requires robust experimental tools to analyze the human–machine interaction, particularly under conditions of system disengagement.
Juan F. Dols, Samuel Boix, Jaime Molina, Sara Moll, Francisco J. Camacho, Griselda López   +5 more
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Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

BMC Molecular and Cell Biology, 2021
Background Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1.
Kazuki Matsumura, Takushi Shimomura, Yoshihiro Kubo, Takayuki Oka, Naohiro Kobayashi, Shunsuke Imai, Naomi Yanase, Madoka Akimoto, Masahiro Fukuda, Mariko Yokogawa, Kazuyoshi Ikeda, Jun-ichi Kurita, Yoshifumi Nishimura, Ichio Shimada, Masanori Osawa   +14 more
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The Strength of hERG Inhibition by Erythromycin at Different Temperatures Might Be Due to Its Interacting Features with the Channels

Molecules, 2023
Erythromycin is one of the few compounds that remarkably increase ether-a-go-go-related gene (hERG) inhibition from room temperature (RT) to physiological temperature (PT).
Dongrong Cheng, Xiaofeng Wei, Yanting Zhang, Qian Zhang, Jianwei Xu, Jiaxin Yang, Junjie Yu, Antony Stalin, Huan Liu, Jintao Wang, Dian Zhong, Lanying Pan, Wei Zhao, Yuan Chen   +13 more
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In vitro chronic effects on hERG channel caused by the marine biotoxin Yessotoxin.

Frontiers in Marine Science, 2014
INTRODUCTION Marine algal blooms caused by the overgrowth of marine phytoplankton have increased in frequency and severity in the last years; supposing a worldwide public health problem.
Sara Fernández Ferreiro
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Modulation of hERG 1a Trafficking by hERG 1b Subunits in Heart [PDF]

Biophysical Journal, 2016
In human heart the rapid component of the delayed rectifier potassium current (IKr), is an important contributor to repolarization. IKr exists as heterotetrameric channel complexes composed of hERG 1a/1b subunits. hERG 1b is defined by a shorter and unique N-terminus that lacks the Per-Arnt-Sim or ether-a-go-go, domain with implications for its role in
Aromolaran, Kelly A., Chang, Donald D., Zukin, R. Suzanne, Colecraft, Henry M., Chahine, Mohamed, Boutjdir, Mohamed, Aromolaran, Ademuyiwa   +6 more
openaire   +1 more source

Analysis of WT-hERG, G572R-hERG and E637K-hERG protein expressions in HEK293 cells.

, 2013
Lysates from HEK293 cells expressing WT-hERG, G572R-hERG or E637K-hERG were immunoblotted with anti-hERG antibody. Only WT-hERG expressing cells have both the fully-glycosylated, mature form and core-glycosylated, immature form of the hERG protein.
Huan Huan Sun (335949), Di Li (335947), Ningsheng Liu (335951), Xiaoyan Huang (112885), Jiangfang Lian (112879), Jianqing Zhou (112889), Ying Wang (11406), Haiyan Mao (335948), Xi Yang (112884)   +8 more
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Activation of ATF6 by G572R-hERG and E637K-hERG.

, 2013
HEK293 cells were transfected with WT-hERG, G572R-hERG or E637K-hERG plasmid. Cell lysates were subjected to Western blotting with anti-ATF6 antibody. The cleaved, activated form of ATF6 at 50 kDa is only detected in G572R-hERG and E637K-hERG expressing ...
Huan Huan Sun (335949), Di Li (335947), Ningsheng Liu (335951), Xiaoyan Huang (112885), Jiangfang Lian (112879), Jianqing Zhou (112889), Ying Wang (11406), Haiyan Mao (335948), Xi Yang (112884)   +8 more
core   +1 more source

Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the role of Rer1 in hERG potassium channel protein transport,and to study the medicine Baf A1 that may restore abnormal hERG transport.
CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun
doaj