Results 31 to 40 of about 28,801 (226)

High Glucose Represses hERG K+ Channel Expression through Trafficking Inhibition

Cellular Physiology and Biochemistry, 2015
Background/Aims: Abnormal QT prolongation is the most prominent cardiac electrical disturbance in patients with diabetes mellitus (DM). It is well known that the human ether-ago-go-related gene (hERG) controls the rapid delayed rectifier K+ current (IKr)
Yuan-Qi Shi, Meng Yan, Li-Rong Liu, Xiao Zhang, Xue Wang, Huai-Ze Geng, Xin Zhao, Bao-Xin Li   +7 more
doaj   +1 more source

The Strength of hERG Inhibition by Erythromycin at Different Temperatures Might Be Due to Its Interacting Features with the Channels

Molecules, 2023
Erythromycin is one of the few compounds that remarkably increase ether-a-go-go-related gene (hERG) inhibition from room temperature (RT) to physiological temperature (PT).
Dongrong Cheng, Xiaofeng Wei, Yanting Zhang, Qian Zhang, Jianwei Xu, Jiaxin Yang, Junjie Yu, Antony Stalin, Huan Liu, Jintao Wang, Dian Zhong, Lanying Pan, Wei Zhao, Yuan Chen   +13 more
doaj   +1 more source

Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

Cellular Physiology and Biochemistry, 2014
Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted by various pro-arrhythmic drugs.
Kaiping Zhang, Duo Zhi, Ting Huang, Yan Gong, Meng Yan, Chen Liu, Ting Wei, Zengxiang Dong, Baoxin Li, Baofeng Yang   +9 more
doaj   +1 more source

Structural modeling of hERG channel–drug interactions using Rosetta

Frontiers in Pharmacology, 2023
The human ether-a-go-go-related gene (hERG) not only encodes a potassium-selective voltage-gated ion channel essential for normal electrical activity in the heart but is also a major drug anti-target.
Aiyana M. Emigh Cortez, Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kevin R. DeMarco, Kazuharu Furutani, Kazuharu Furutani, Slava Bekker, Slava Bekker, Jon T. Sack, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Colleen E. Clancy, Colleen E. Clancy, Igor Vorobyov, Igor Vorobyov, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +17 more
doaj   +1 more source

The Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS): survey design, data catalogue and GAMA/WiggleZ spectroscopy [PDF]

, 2016
© 2016 The Authors. We present the Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS), a spectroscopic catalogue of radio sources designed to include the full range of radio AGN populations out to redshift z ~ 0.8. The catalogue covers ~800
Ching, John H.Y., Couch, Warrick J., Croom, Scott M., Hopkins, A. M., Johnston, Helen M., Jurek, Russell J., Pimbblet, K. A., Pracy, Michael B., Sadler, Elaine M.   +8 more
core   +2 more sources

Compact steep-spectrum sources as the parent population of flat-spectrum radio-loud NLS1s [PDF]

, 2016
Narrow-line Seyfert 1 galaxies (NLS1s) are an interesting subclass of active galactic nuclei (AGN), which tipically does not exhibit any strong radio emission.
Berton, Marco, Caccianiga, Alessandro, Ciroi, Stefano, Congiu, Enrico, Cracco, Valentina, Foschini, Luigi, Frezzato, Michele, La Mura, Giovanni, Mathur, Smita, Peterson, Bradley M., Rafanelli, Piero, Terreran, Giacomo   +11 more
core   +2 more sources

Modulation of hERG 1a Trafficking by hERG 1b Subunits in Heart [PDF]

Biophysical Journal, 2016
In human heart the rapid component of the delayed rectifier potassium current (IKr), is an important contributor to repolarization. IKr exists as heterotetrameric channel complexes composed of hERG 1a/1b subunits. hERG 1b is defined by a shorter and unique N-terminus that lacks the Per-Arnt-Sim or ether-a-go-go, domain with implications for its role in
Aromolaran, Kelly A., Chang, Donald D., Zukin, R. Suzanne, Colecraft, Henry M., Chahine, Mohamed, Boutjdir, Mohamed, Aromolaran, Ademuyiwa   +6 more
openaire   +1 more source

Analysis of a Driving Simulator’s Steering System for the Evaluation of Autonomous Vehicle Driving

Sensors
The integration of autonomous vehicles (AVs) into road transport requires robust experimental tools to analyze the human–machine interaction, particularly under conditions of system disengagement.
Juan F. Dols, Samuel Boix, Jaime Molina, Sara Moll, Francisco J. Camacho, Griselda López   +5 more
doaj   +1 more source

Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A [PDF]

British Journal of Anaesthesia, 2004
Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established.
P, Friederich, A, Solth, S, Schillemeit, D, Isbrandt   +3 more
openaire   +2 more sources

In vitro chronic effects on hERG channel caused by the marine biotoxin Yessotoxin.

Frontiers in Marine Science, 2014
INTRODUCTION Marine algal blooms caused by the overgrowth of marine phytoplankton have increased in frequency and severity in the last years; supposing a worldwide public health problem.
Sara Fernández Ferreiro
doaj   +1 more source