Results 101 to 110 of about 28,801 (226)

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression [PDF]

, 2017
The data presented in this article are related to the research article entitled “The effects of deoxyelephantopin on the cardiac delayed rectifier potassium channel current (IKr) and human ether-a-go-go-related gene (hERG) expression” (Y.F.
Abduraman, Muhammad Asyraf, Adenan, Mohd Ilham, Amanah, Azimah, Mei, Lan Tan, Sulaiman, Shaida Fariza, Yi, Fan Teah   +5 more
core   +2 more sources

QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults

Journal of the American Geriatrics Society, EarlyView.
Francesco Fantin, Sara Fiorini, Anna Giani, Luana Giacobbe, Elena Zoico, Gianluca Trifirò, Rocco Micciolo, Mauro Zamboni   +7 more
wiley   +1 more source

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1385-1396, May 2026.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

Construction of an integrated database for hERG blocking small molecules.

PLoS ONE, 2018
The inhibition of the hERG potassium channel is closely related to the prolonged QT interval, and thus assessing this risk could greatly facilitate the development of therapeutic compounds and the withdrawal of hazardous marketed drugs.
Tomohiro Sato, Hitomi Yuki, Keiji Ogura, Teruki Honma   +3 more
doaj   +1 more source

Chemical Profiling and Biological Activity of Copaiba Oil‐Resin Samples and Development of HPLC‐DAD Method for the Analysis of β‐Caryophyllene

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT The Copaifera species are traditionally used for their anti‐inflammatory, antiseptic and healing properties. The objective of this study was to compare the chromatographic profiles of seven samples of copaiba oil‐resin with respect to chromatographic and physicochemical properties and to evaluate their biological activities.
Gabriel de A. P. Graça, Cláudia G. Silva, Denise de O. Scoaris, Juliana Rodrigues de Vasconcelos, André Santos Alkimim, Vanessa C. F. Mosqueira, Luciana S. Salomon, Pietra Piotto Marcellini, Isabelle Renata Martins da Silva, Janete S. C. Santos, Andreia Fonseca Silva, Carolina P. S. Moreira, Júlio C. D. Lopes, Vera L. de Almeida   +13 more
wiley   +1 more source

Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel

Journal of Pharmacological Sciences, 2013
We investigated the effects of Ginkgo biloba extract (GBE) and ginkgolide (GLD) on human ether-a-go-go-related gene (hERG)-encoded K+ channels and its underlying mechanisms in the hERG-HEK293 cell line by determining GBE- and GLD-induced changes in ...
Xin Zhao, Hong Yao, Hao-Lan Yin, Qi-Lei Zhu, Jia-Liang Sun, Wei Ma, Yuan-Qi Shi, Zhao-Guang Liang, Bao-Xin Li   +8 more
doaj   +1 more source

Assessing the payback from health R & D: From ad hoc studies to regular monitoring [PDF]

, 2010
Chapter 1 : Introduction • The increasing demands for the benefits of payback from publicly funded R&D to be assessed are based partly on the need to justify or account for expenditure on R&D, and partly on the desire for information to assist resource ...
Buxton, MJ, Croxson, B, Hanney, S
core  

Tetrandrine, a Major Alkaloid From Stephaniae Tetrandrae Radix, Ameliorates Non‐Alcoholic Fatty Liver Disease in Zebrafish via the PI3K/AKT/STAT3 Pathway

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Tet regulates lipid metabolism and cell apoptosis to alleviate NAFLD. Integrated network pharmacology, Mendelian randomization, and experimental validation demonstrate that Tet activates the PI3K/AKT/STAT3 signaling axis, suppresses apoptosis, reduces hepatic lipid accumulation, and improves biochemical liver injury markers, supporting its potential as
Peng Sun, Jun Wu, Kai Ma, Xiaoli Wei, Jing Ma, Wenhao Han, Xiaoyu Zhu, Xinyu Zhang, Xi Wang, Tangnuer Tuersunniyazi, Wei Gong, Hong Lin   +11 more
wiley   +1 more source

Antennaria dioica (L.) Gaertn. (Asteraceae): From Metabolite Profiling to Comprehensive Evaluation of In Vitro and In Silico Enzyme Inhibitory Activity

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Antennaria dioica (L.) Gaertn. is a perennial herb from the tribe Gnaphalieae of the Asteraceae family. In‐depth phytochemical profiling and in vitro antioxidant and enzyme inhibition assessment of methanol‐aqueous extract from the A. dioica aerial parts were integrated with molecular docking study.
Dimitrina Zheleva‐Dimitrova, Gokhan Zengin, Iglika Lessigiarska, Ivanka Tsakovska, Radostina Nikolova‐Kejova, Ivayla Zheleva‐Kyuchukova, Georgi Momekov, Reneta Gevrenova   +7 more
wiley   +1 more source