Results 101 to 110 of about 5,479 (195)
Effect of continuous hypoxia (CH) on hERG interaction with Hsp90.
, 2019 A) Representative immunoblot showing the effect of geldnamycin (1μg/ml) on hERG protein expression in cells exposed to normoxia (N) and CH4d. B) Time course of geldnamycin effect on hERG protein under normoxic conditions.
Nanduri R. Prabhakar (467090) +5 more
core +1 more source
Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu +2 more
wiley +1 more source
A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel
Journal of Pharmacological Sciences, 2009 We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG currents) independently of estrogen-receptor signaling.
Shoko Kakusaka +6 more
doaj +1 more source
Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil–Ciprofloxacin Combination
Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.With an estimated prevalence of 15.52% in Moroccan poultry, Campylobacter species pose a significant food safety concern. We investigated whether essential oils (EOs) could restore the efficacy of ciprofloxacin against multidrug‐resistant (MDR) strains.
Zineb Soubai +13 more
wiley +1 more source
Restoration of mutant hERG stability by inhibition of HDAC6 [PDF]
The human ether-a-go-go-related gene (hERG) encodes the α subunit of a rapidly activating delayed-rectifier potassium (IKr) channel. Mutations of the hERG cause long QT syndrome type 2 (LQT2).
90294321 +47 more
core
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
Journal of Pharmacological Sciences, 2008 Block of cardiac hERG K+ channels by the antihistamine terfenadine and the prokinetic agent cisapride is associated with prolonged ventricular repolarization and an increased risk of ventricular arrhythmia.
Kaichiro Kamiya +4 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 19, 14 October 2026.A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain +6 more
wiley +1 more source
Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova +3 more
wiley +1 more source