Results 111 to 120 of about 28,801 (226)
From bench to bedside: Tracing the payback forwards from basic or early clinical research – A preliminary exercise and proposals for a future study [PDF]
, 2010 EXECUTIVE SUMMARY Chapter 1 : Introduction • The members of the research team from HERG and the Wellcome Trust have conducted previous studies showing that it is possible both to assess the payback from applied health research, and to use bibliometrics
Buxton, MJ +4 more
core
The Potential Role of Verapamil Against Fluconazole‐Induced Torsade de Pointes: A Critical Review
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Fluconazole (FZL) is a broad‐spectrum antifungal drug associated with certain serious adverse effects such as polymorphic ventricular arrhythmia due to QT prolongation. Torsade de Pointes (TdP) is a unique type of polymorphic ventricular arrhythmia due to QT prolongation.
Noha E. Abdel‐Razik +7 more
wiley +1 more source
Journal of Pharmacological Sciences, 2019 The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. Reduction of hERG activity induced by gene mutations or pharmacological inhibition is responsible for
Xiuming Dong +6 more
doaj +1 more source
Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications
MedComm, Volume 7, Issue 5, May 2026.Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang +6 more
wiley +1 more source
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. [PDF]
, 1998 A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two
Goldstein, SA +3 more
core
, 2019 Radio AGNs with intermediate radio powers are capable of driving multi-phase outflows in galaxy bulges, and are also more common than their high-radio-power counterparts.
Almeida, Cristina Ramos +4 more
core +1 more source
A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel
Journal of Pharmacological Sciences, 2009 We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K+ currents (hERG currents) independently of estrogen-receptor signaling.
Shoko Kakusaka +6 more
doaj +1 more source
Project Retrosight. Understanding the returns from cardiovascular and stroke research: Methodology Report [PDF]
, 2011 Copyright @ 2011 RAND Europe. All rights reserved. The full text article is available via the link below.This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and attempts to draw out aspects of the ...
Buxton, MJ +4 more
core
Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
Journal of Pharmacological Sciences, 2008 Block of cardiac hERG K+ channels by the antihistamine terfenadine and the prokinetic agent cisapride is associated with prolonged ventricular repolarization and an increased risk of ventricular arrhythmia.
Kaichiro Kamiya +4 more
doaj +1 more source