Results 111 to 120 of about 5,479 (195)

State transition diagram of the Markov model for the hERG channel.

, 2016
– are closed states, O[hERG] is the open state and I[hERG] the inactivation state.
Conor McCloskey (3172887), Jolene Atia (3172896), David A. Rand (224922), Hugo A. van den Berg (3172899), Andrew M. Blanks (3172890), Anatoly S. Shmygol (3172893)   +5 more
core   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1 [PDF]

Background:The human ether-a-go-go-related gene (HERG) encodes the α-subunit of rapidly activating delayed-rectifier potassium channels. Mutations in this gene cause long QT syndrome type 2 (LQT2).
飯塚, 和彦, Ogura, Kazuyoshi, Miake, Junichiro, Nakasone, Naoe, 40372677, Shimizu, Wataru, Nakai, Akira, 4848, 1457, 白吉, 安昭, Yoshimura, Shouichi, Ninomiya, Haruaki, 三明, 淳一朗, 小倉, 一能, 3130, 90249946, Li, Peili, 880, 100000078, 765, 4730, ヨシダ, アキオ, 100000877, 二宮, 治明, 90294321, Hisatome, Ichiro, 3385, 90303966, Kurata, Yasutaka, 倉田, 康孝, 仲宗根, 眞恵, 40467709, Yamamoto, Kazuhiro, 100000304, 2609, 100000307, Notsu, Tomomi, 1879, Iizuka, Kazuhiko, ヒガキ, カツミ, Mahati, Endang, 坂田, 晋史, Kawata, Yasushi, 100000496, 1367, コンドウ, タケヒト, 久留, 一郎, 100000259, 40177697, 4755, ヒサトメ, イチロウ, 山本, 一博, 河田, 康志, 100000280, Sakata, Shinji, 100001496, ニノミヤ, ハルアキ, 李, 佩俐, サカタ, シンジ, 近藤, 健人, 100000847, Aiba, Takeshi, 40464292, 加藤, 克, リ, ペイリ, ノツ, トモミ, 685, Kato, Masaru, イイズカ, カズヒコ, シラヨシ, ヤスアキ, Yoshida, Akio, 26859, オグラ, カズヨシ, マハティ, エンダン, 26852, 26851, 26854, 26853, 26856, 26855, 26858, 26857, 100000343, 100000740, 100000348, クラタ, ヤスタカ, 檜垣, 克美, Shirayoshi, Yasuaki, 4288, 60211504, 26863, 26862, Higaki, Katsumi, 26864, カトウ, マサル, カワタ, ヤスシ, 80212124, 100000212, 26861, 30632947, 26860, ミアケ, ジュンイチロウ, ナカソネ, ナオエ, Kondo, Takehito   +103 more
core  

Development of Benzothiophene–Bearing Bis–oxadiazole Derivatives for Potential Anticancer Targets: Evaluation of DFT, ADME–Tox, and In Silico Docking

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Innovative synthesis of a novel benzothiophene–based bis–oxadiazole derivatives. The structural characterization was performed using experimental and theoretical methods. Significant anticancer activity against selected cancer cell lines. Three derivatives showed good activity 7b, 7g and 7i with IC50 values 7.5 ± 1.04 and 9.5 ± 1.01 µg/mL.
Nagaraju Madala, Vishal Sharma, Srilalitha Vinnakota   +2 more
wiley   +1 more source

Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules

, 2011
Human ether-a-go-go related gene (hERG) potassium (K(+)) channels play a critical role in cardiac action potential repolarization. Mutations that reduce hERG conductance or surface expression may cause congenital long QT syndrome (LQTS).
Gao ZB(高召兵), Li M(李密), Liu LQ(刘连庆), Zhou, Ping-zheng, Babcock, Joseph   +4 more
core  

Chlorothiophene‐Substituted N‐Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX‐2 Inhibition

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Eight novel N‐phenylpyrazoline derivatives bearing chlorothiophene moieties were synthesized and evaluated for anticancer activity against T47D, MCF7, and WiDr cell lines. Compound 2g showed the strongest cytotoxicity against WiDr cells (IC50 = 19.63 µg/mL) with the highest selectivity index (665.88), highlighting its potential as a selective ...
Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih   +4 more
wiley   +1 more source

Specificity of hERG antibody.

A) Representative immunoblots showing the specificity of the two hERG protein bands (150 and kDa) in SH-SY5Y cells exposed to normoxia (N) or 2days of hypoxia (CH2d) probed with hERG antibody (left two lanes) or with hERG antibody preadsorbed overnight ...
Jayasri Nanduri (467086), Ning Wang (108353), Lin Piao (4452487), Damodara Reddy Vaddi (17775617), Nanduri R. Prabhakar (17775623), Shakil A. Khan (17775620)   +5 more
core   +1 more source

Anti‐Inflammatory Activity of Cotula cinerea Essential Oil: Integrated Chemical, In Vivo, Histological, and Computational Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Cotula cinerea essential oil was chemically profiled and evaluated in an exploratory in vivo model with histological assessment, while computational analyses generated hypotheses for interactions of selected constituents with COX‐2 and BSA. The predictive findings require direct experimental validation. ABSTRACT The anti‐inflammatory activity of Cotula
Habiba Haddad, Mohammed Larbi Benamor, Yahia Bekkar, Ouafa Boudebia, Salah Neghmouche Nacer, Elhafnaoui Lanez, Aicha Adaika, Taher M. Abdelhameed, Lazhar Bechki, Touhami Lanez, Stefania Garzoli   +10 more
wiley   +1 more source

Integrated Biological Evaluation of Benzimidazolium–Chalcone Derivatives: Antioxidant, Anti‐AChE, Anticancer, and Anti‐MRSA Activities With Docking Insights

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Four benzimidazolium–chalcone derivatives were synthesized and explored for their multifunctional biological activities. The compounds exhibit distinct antioxidant, AChE inhibitory, antibacterial, antibiofilm, and apoptotic activities, supported by molecular docking analysis.
Mehmet Çimentepe, Hakan Ünver, Adem Necip, Mehmet Ersatir, Burcu Demirbağ, Özge Öztürk Çimentepe, Metin Yildirim   +6 more
wiley   +1 more source

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone.

, 2020
UNLABELLED: The aim of this study was to determine the effects of desethyl-amiodarone (DEA), the major metabolite of the class III antiarrhythmic drug amiodarone, on human ether-à-go-go-related gene (hERG) encoded potassium channel current. MATERIALS AND
Zhang, YH, Cheng, H, Alexeenko, VA, Dempsey, CE, Hancox, JC   +4 more
core   +1 more source