Results 131 to 140 of about 28,801 (226)

Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity. [PDF]

ACS Med Chem Lett
Khan I, Hettikankanamalage AA, Cui Y, Crich D.   +3 more
europepmc   +1 more source

SPARC: a structural pathogenicity algorithm for risk classification of hERG variants. [PDF]

Europace
Chatelain FC, de Oliveira BR, Grataloup G, Robert N, Alameh M, Thollet A, Montnach J, Feliciangeli S, Rio A, Bibault F, Bichet D, Bignucolo O, Extramiana F, Majumder R, Schott JJ, Probst V, Denjoy I, Lesage F, Loussouarn G, De Waard M.   +19 more
europepmc   +1 more source

Pharmacokinetic Prediction of Repurposed Drugs for PDAC Using Artificial Intelligence. [PDF]

ACS Omega
Pragya P, Singh S, Balasubramaniam B, Agastinose Ronickom JF.   +3 more
europepmc   +1 more source

Personalized in vitro models reveal functional impact of a <i>KCNH2</i> mutation and enable drug screening in LQTS2. [PDF]

Heart Rhythm O2
Zheng B, Zhu Y, Sun M, Cheng H, Zhang S, Cai C, Gu K, An Y, Ding X, Zhang F, Cui C, Chen M.   +11 more
europepmc   +1 more source

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues. [PDF]

Drug Dev Res
Chenu E, Duffy J, Forkuo AD, Gbedema SY, Abdelall S, Wahajuddin M, Jones HS, Wright CW.   +7 more
europepmc   +1 more source

Reciprocal action of a synthetic estrogen and hERG blockers on the hERG channel

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
Shintaro Sugimoto, Fumiya Tamura, Nanami Iwasaki, Masaki Ieda, Kazuho Sakamoto, Junko Kurokawa   +5 more
openaire   +2 more sources

Amiodarone irrecoverably impairs the function of human ether-a-go-go-related gene potassium channels. [PDF]

Mol Pharmacol
Gelman I, Li W, Guo J, Bogart-Cherry R, Tomei N, Sharma N, Pan A, Yang T, Baranchuk A, El-Diasty M, Zhang S.   +10 more
europepmc   +1 more source

Do all voltage-gated potassium channels use MiRPs? [PDF]

, 2001
Abbott, GW, Goldstein, SA, Sesti, F
core  

Second-generation antipsychotics - Cardiac ion channel modulation and QT interval disturbances: A review. [PDF]

Biomol Biomed
Erkan O, Dai AS, Ozturk N, Ozdemir S.
europepmc   +1 more source

Advancing Torsades de pointes risk prediction: unveiling the role of drug metabolites through molecular docking. [PDF]

Toxicol Res (Camb)
Bilgin E, Tugcu G, Aydin A.
europepmc   +1 more source