Results 141 to 150 of about 5,479 (195)
Identification of Sodium/Myo‐Inositol Transporter 1 as a Major Determinant of Arterial Contractility
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.The tonicity‐responsive enhancer binding‐protein (TonEBP) and serum glucocorticoid kinase (SGK) sense a rise in extracellular hypertonicity resulting in an increase SMIT1 membrane abundance in vascular smooth muscle cells. SMIT1 associates with Kv7.4/5, Gβγ, and KCNE4, promoting hyperpolarization, reduced voltage‐gated calcium channel (VGCC) opening ...
Elizabeth A. Forrester +6 more
wiley +1 more source
Regulation of HERG channel bio-processing
, 2011 The long QT syndrome (LQTS) is a common cardiac disorder with potentially lethal consequences. While mostly asymptomatic, LQTS patients may develop Torsade de Pointes (TdP) arrhythmia, which can proceed into ventricular fibrillation causing death.
Sroubek, Jakub
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Reciprocal action of a synthetic estrogen and hERG blockers on the hERG channel
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019 Shintaro Sugimoto +5 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1999
The rapid, repolarizing K+ current in cardiomyocytes ( I Kr) has unique inwardly rectifying properties that contribute importantly to the downstroke of the cardiac action potential. The human ether-à-go-go-related gene ( HERG) expresses a macroscopic current virtually identical to I Kr, but a description of the single-channel properties that cause ...
J, Kiehn, A E, Lacerda, A M, Brown
openaire +2 more sources
The rapid, repolarizing K+ current in cardiomyocytes ( I Kr) has unique inwardly rectifying properties that contribute importantly to the downstroke of the cardiac action potential. The human ether-à-go-go-related gene ( HERG) expresses a macroscopic current virtually identical to I Kr, but a description of the single-channel properties that cause ...
J, Kiehn, A E, Lacerda, A M, Brown
openaire +2 more sources
Science, 1996
Since our 7 July 1995 report “HERG, a human inward rectifier in the voltage-gated potassium channel family” was published ([1][1]), two previously undetected differences between our expression clone and the published nucleotide sequence ([2][2]) have been identified: T593A, yielding amino acid change V198E; and C605T, yielding P202L.
M C, Trudeau +3 more
openaire +3 more sources
Since our 7 July 1995 report “HERG, a human inward rectifier in the voltage-gated potassium channel family” was published ([1][1]), two previously undetected differences between our expression clone and the published nucleotide sequence ([2][2]) have been identified: T593A, yielding amino acid change V198E; and C605T, yielding P202L.
M C, Trudeau +3 more
openaire +3 more sources
A Composite Model for hERG Blockade [PDF]
ChemMedChem, 2008 AbstracthERG blockade is one of the major toxicological problems in lead structure optimization. Reliable ligand‐based in silico models for predicting hERG blockade therefore have considerable potential for saving time and money, as patch‐clamp measurements are very expensive and no crystal structures of the hERG‐encoded channel are available.
Kramer, C. +3 more
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Journal of Chemical Information and Modeling, 2013
A detailed analysis of the hERG content inside the ChEMBL database is performed. The correlation between the outcome from binding assays and functional assays is probed. On the basis of descriptor distributions, design paradigms with respect to structural and physicochemical properties of hERG active and hERG inactive compounds are challenged. Finally,
openaire +2 more sources
A detailed analysis of the hERG content inside the ChEMBL database is performed. The correlation between the outcome from binding assays and functional assays is probed. On the basis of descriptor distributions, design paradigms with respect to structural and physicochemical properties of hERG active and hERG inactive compounds are challenged. Finally,
openaire +2 more sources
EFFECT OF HERG CURRENT BY DRUGS IN hERG TRAFFICKING MUTANTS
Journal of Pharmacological and Toxicological Methods, 2007Mutations in the potassium channel encoded by the human ether-a-go-go-related gene (hERG) have been linked to inherited long QT syndrome (LQTS), a cardiac disease associated with an increased susceptibility to life-threatening ventricular arrhythmias and sudden death. Among these mutations, LQT2 mutation caused in cyclic nucleotide binding domain (CNBD)
Ki-Suk Kim +4 more
openaire +1 more source