Results 161 to 170 of about 5,479 (195)
Some of the next articles are maybe not open access.
GraphDeep-hERG: Graph Neural Network PharmacoAnalytics for Assessing hERG-Related Cardiotoxicity
Pharmaceutical ResearchThe human Ether-a-go-go Related-Gene (hERG) encodes rectifying potassium channels that play a significant role during action potential repolarization of cardiomyocytes. Blockade of the hERG channel by off-target drugs can lead to long QT syndrome, significantly increasing the risk of proarrhythmic cardiotoxicity.
Yankang Jing +9 more
openaire +2 more sources
Novartis Foundation symposium, 2005
Mutations in the cardiac potassium channel hERG/IKr cause inherited long QT syndrome with increased susceptibility to ventricular arrhythmias. Several mutations in hERG produce trafficking-deficient channels that are retained in the endoplasmic reticulum (ER). Surface expression of certain mutations (i.e. hERG G601S) can be restored by specific channel
Eckhard, Ficker +4 more
openaire +1 more source
Mutations in the cardiac potassium channel hERG/IKr cause inherited long QT syndrome with increased susceptibility to ventricular arrhythmias. Several mutations in hERG produce trafficking-deficient channels that are retained in the endoplasmic reticulum (ER). Surface expression of certain mutations (i.e. hERG G601S) can be restored by specific channel
Eckhard, Ficker +4 more
openaire +1 more source
Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole
Structure, 2021Satoshi Ogasawara +2 more
exaly
HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential
Biochimica Et Biophysica Acta: Reviews on Cancer, 2020Amit R L Persad, Humphrey Fonge
exaly
Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG
Cell, 2017Roderick MacKinnon, Weiwei Wang
exaly
Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels
Circulation Research, 1999Shetuan Zhang +2 more
exaly