Results 171 to 180 of about 28,801 (226)

Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels. [PDF]

Nat Commun
Chan AN, Quach CD, Handlin LJ, Lessie EN, Tajkhorshid E, Dai G.   +5 more
europepmc   +1 more source

Molecular insights into the bioactivity of H-thiazine compounds against breast cancer cells: a computational study. [PDF]

In Silico Pharmacol
Mogoane LM, Obakachi VA, Govender PP, Govender KK.   +3 more
europepmc   +1 more source

Unveiling optimal molecular features for hERG insights with automatic machine learning. [PDF]

J Pharm Anal
Xu C, Xu Y, Hu Z, Zhao X, Xie W, Chen W, Pei J.   +6 more
europepmc   +1 more source

Harnessing AlphaFold to reveal hERG channel conformational state secrets. [PDF]

Elife
Ngo K, Yang PC, Yarov-Yarovoy V, Clancy CE, Vorobyov I.   +4 more
europepmc   +1 more source

Virtual Screening-Guided Discovery of a Selective TRPV1 Pentapeptide Inhibitor with Topical Anti-Allergic Efficacy. [PDF]

Cells
Liu L, Hou W, He Q, Yuan F, Guo C, Liu R, Huang B, Wubulikasimu A, Rong M.   +8 more
europepmc   +1 more source

Assay2Mol: Large Language Model-based Drug Design Using BioAssay Context. [PDF]

Proc Conf Empir Methods Nat Lang Process
Deng Y, Ericksen SS, Gitter A.
europepmc   +1 more source

Assessing the efficacy of combined treatment using bedaquiline against clinical isolates of multidrug-resistant Mycobacterium tuberculosis in vitro and the macrophage model. [PDF]

BMC Microbiol
Ahmadi K, Madadi-Goli N, Azizi M, Hadifar S, Ebrahimzadeh N, Masoumi M, Nasehi M, Siadat SD, Fateh A, Vaziri F.   +9 more
europepmc   +1 more source

Qualitative and quantitative in silico toxicity profiling of "angel dust": phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE). [PDF]

Arch Toxicol
Noga M, Jurowski K.
europepmc   +1 more source

Machine Learning for Predicting Human Drug-Induced Cardiotoxicity: A Scoping Review. [PDF]

Toxics
Han JY, Kim MJ, Kim H, Choi K, Ju S, Kim MG.   +5 more
europepmc   +1 more source

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Pathways of HERG inactivation

American Journal of Physiology-Heart and Circulatory Physiology, 1999
The rapid, repolarizing K+ current in cardiomyocytes ( I Kr) has unique inwardly rectifying properties that contribute importantly to the downstroke of the cardiac action potential. The human ether-à-go-go-related gene ( HERG) expresses a macroscopic current virtually identical to I Kr, but a description of the single-channel properties that cause ...
J, Kiehn, A E, Lacerda, A M, Brown
openaire   +2 more sources