Results 151 to 160 of about 28,801 (226)

Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1. [PDF]

J Biol Chem
Sanchez-Conde FG, Goodrich MR, Stack OM, Goldberg LNR, Ruzycki PK, Jain A, Jimenez-Vazquez EN, Jones DK.   +7 more
europepmc   +1 more source

Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds. [PDF]

J Xenobiot
Kasemnitichok Y, Lee S, Kwon OB, Plengsuriyakarn T, Na-Bangchang K.   +4 more
europepmc   +1 more source

Electrocardiogram abnormalities in patients with acne undergoing isotretinoin therapy: a focused review. [PDF]

An Bras Dermatol
Islam AW, Motdhare P, Mohan S, Bejoy S, Wilkhoo HS.   +4 more
europepmc   +1 more source

Cardiovascular safety pharmacology: beyond arrhythmic risk assessment. [PDF]

Front Cardiovasc Med
Fares R, Champéroux P.
europepmc   +1 more source

AI-Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR-Tractable RNA Binders and Rational Analog Design. [PDF]

Small Sci
Hattori H, Otsu M, Imai K, Narahara M, Kondo J, Shino A, Morishita EC.   +6 more
europepmc   +1 more source

An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors. [PDF]

Clin Transl Sci
Mukker JK, Yap TA, Tolcher AW, de Bono JS, Plummer R, Grosser G, van Amsterdam C, Schieferstein H, Witjes H, Diderichsen PM, Krebs-Brown A, Gao W, Strotmann R, Szucs Z, Gounaris I, Venkatakrishnan K.   +15 more
europepmc   +1 more source

Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity. [PDF]

Toxicol Appl Pharmacol
Luo X, Zhang L, Sakamuru S, Adesina PA, Zhao J, Xia M, Xu T, Ngan DK, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson SS, Zhu H, Hall MD, Reif DM, Huang R.   +17 more
europepmc   +1 more source

Toxicity of fentanyl (CAS: 437-38-7) and valerylfentanyl (CAS: 122882-90-0): the first integrative in silico toxicology study with clinical and forensic implications. [PDF]

Arch Toxicol
Niżnik Ł, Fijałkowska O, Jurowski K.
europepmc   +1 more source

Optical control of the cardiac rhythm with photoswitchable Na_V1.5 channel blockers. [PDF]

Nat Commun
Liu S, Guan W, Li Z, Wang W, Song H, Li J, Hou J, Wang H, Xiong J, Yang M, Yan N, Tian X, Li H, Huang Z.   +13 more
europepmc   +1 more source

Discovery of a novel broad-spectrum inhibitor against influenza virus A. [PDF]

Virol J
Yu R, Li P, Shen R, Fei W.
europepmc   +1 more source