Results 111 to 120 of about 36,434 (294)
Plant Biotechnology Journal, EarlyView.Peptide Power: VR18 & KG18 Shield Tobacco from Bacterial Attack. A schematic shows how antimicrobial peptides VR18 and KG18 fight Pseudomonas syringae—bursting bacterial membranes and boosting disease resistance in transgenic tobacco, without harming plant health.
Karishma Biswas +17 more
wiley +1 more source
Compact steep-spectrum sources as the parent population of flat-spectrum radio-loud NLS1s [PDF]
, 2016 Narrow-line Seyfert 1 galaxies (NLS1s) are an interesting subclass of active galactic nuclei (AGN), which tipically does not exhibit any strong radio emission.
Berton, Marco +11 more
core +2 more sources
Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. [PDF]
PLoS ONE, 2015 Tannic acid presents in varying concentrations in plant foods, and in relatively high concentrations in green teas and red wines. Human ether-à-go-go-related gene (hERG) channels expressed in multiple tissues (e.g.
Xi Chu +7 more
doaj +1 more source
Results in Chemistry, 2021 A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
doaj +1 more source
Biophysical Journal, 2013 The delayed rectifier, IKr, is formed by homo/heterotetramers of the 2 HERG splice variants HERG1a and HERG1b. The only difference between isoforms is that HERG1b has a shorter N-terminal than HERG1a. Despite their similarities, HERG1a and 1b have profoundly different gating kinetics: HERG1b has faster activation and deactivation kinetics than HERG1a ...
Zhou, Qinlian, Lis, Agnieszka, Bett, G.
openaire +1 more source
Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent
Experimental Physiology, EarlyView.Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí +4 more
wiley +1 more source
Ion channels: structural basis for function and disease. [PDF]
, 1996 Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core +1 more source
The Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS): survey design, data catalogue and GAMA/WiggleZ spectroscopy [PDF]
, 2016 © 2016 The Authors. We present the Large Area Radio Galaxy Evolution Spectroscopic Survey (LARGESS), a spectroscopic catalogue of radio sources designed to include the full range of radio AGN populations out to redshift z ~ 0.8. The catalogue covers ~800
Ching, John H.Y. +8 more
core +2 more sources
hERG Blockade by Iboga Alkaloids
Cardiovascular Toxicology, 2015 The iboga alkaloids are a class of naturally occurring and synthetic compounds, some of which modify drug self-administration and withdrawal in humans and preclinical models. Ibogaine, the prototypic iboga alkaloid that is utilized clinically to treat addictions, has been associated with QT prolongation, torsades de pointes and fatalities.
Alper, Kenneth +6 more
openaire +4 more sources