Results 131 to 140 of about 36,434 (294)
Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling
Annals of Neurology, Volume 98, Issue 6, Page 1261-1274, December 2025.Objective Hyperactive KCNT1 potassium channels, caused by gain‐of‐function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug‐resistant seizures and, in cases with infantile onset, developmental regression can follow.
Michael G. Ricos +9 more
wiley +1 more source
Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.ABSTRACT Ipomoea obscura (L.), a medicinal plant from the Convolvulaceae family, has been traditionally used to treat various ailments. This study evaluated the in vitro cytotoxicity of its ethanolic leaf extract against human bladder cancer T24 cells and investigated its phytochemical constituents through computational methods.
Saravana Prabha Poochi +8 more
wiley +1 more source
Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. [PDF]
, 1998 A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two
Goldstein, SA +3 more
core
Frontiers in Pharmacology, 2018 The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes ...
Saba Munawar +7 more
doaj +1 more source
Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Gobind Kumar +10 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.This study investigated the antidiabetic potential of adzuki bean β‐vignin and soybean β‐conglycinin peptides in human liver cells in healthy and insulin‐resistant states. Peptide Val‐Pro was found to inhibit dipeptidyl peptidase IV and stimulate the insulin signaling pathway, suggesting the potential for developing healthier adzuki bean‐based ...
Shu Hang Kwan, Elvira Gonzalez de Mejia
wiley +1 more source
Brightest Cluster Galaxies in the Extended GMRT radio halo cluster sample. Radio properties and cluster dynamics [PDF]
, 2015 Brightest Cluster Galaxies (BCGs) show exceptional properties over the whole electromagnetic spectrum. Their special location at the centres of galaxy clusters raises the question of the role of the environment on their radio properties.
Bardelli, sandro +6 more
core +2 more sources
New Insights into Ion Channels: Predicting hERG-Drug Interactions [PDF]
, 2022 Michael F. Wempe
openalex +1 more source
MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation
Cancer Genomics & Proteomics, 2019 Background/Aim: hERG potassium channels enhance tumor invasiveness and breast cancer proliferation. MicroRNA (miRNA) dysregulation during cancer controls gene regulation. The objective of this study was to identify miRNAs that regulate hERG expression in
Abdullah A Assiri +6 more
semanticscholar +1 more source
ChemistryOpen, Volume 14, Issue 12, December 2025.Structure‐based virtual screening of PubChem compounds identifies two novel epalrestat and ranirestat‐like inhibitors with improved affinity and pharmacokinetic profiles targeting aldose reductase. Molecular docking, ADMET filtering, and 500‐ns molecular dynamics simulations confirm the stability and interaction specificity of the candidates ...
Mohd Shahnawaz Khan +3 more
wiley +1 more source