Results 141 to 150 of about 36,434 (294)

Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel

Journal of Pharmacological Sciences, 2013
We investigated the effects of Ginkgo biloba extract (GBE) and ginkgolide (GLD) on human ether-a-go-go-related gene (hERG)-encoded K+ channels and its underlying mechanisms in the hERG-HEK293 cell line by determining GBE- and GLD-induced changes in ...
Xin Zhao, Hong Yao, Hao-Lan Yin, Qi-Lei Zhu, Jia-Liang Sun, Wei Ma, Yuan-Qi Shi, Zhao-Guang Liang, Bao-Xin Li   +8 more
doaj   +1 more source

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis

ChemistryOpen, Volume 14, Issue 12, December 2025.
A regioselective synthesis of fused thiazoles was achieved via aza‐Michael cyclization of thiazolidinone derivatives with hydrazines or heteroaryl amines. Density functional theory, local reactivity indices, and molecular electrostatic potential mapping are used to explain selectivity.
Ghaferah H. Al‐Hazmi, Jehan Y. Al‐Humaidi, Sayed M. Riyadh, Mohamed S. M. Ahmed, Magdi E. A. Zaki, Awatif H. Alruwaili, Khaled A. Alanazi, Rajeh H. Almutairi, Sobhi M. Gomha   +8 more
wiley   +1 more source

Project Retrosight. Understanding the returns from cardiovascular and stroke research: Policy Report [PDF]

, 2011
Copyright @ 2011 RAND Europe. All rights reserved. The full text article and the summary of the article are both available via the links below.This project explores the impacts arising from cardiovascular and stroke research funded 15-20 years ago and ...
Buxton, MJ, Grant, J, Hanney, S, on behalf of the Project Retrosight Team, Pollitt, A, Wooding, S   +5 more
core  

Spin Properties of Supermassive Black Holes with Powerful Outflows

, 2016
Relationships between beam power and accretion disk luminosity are studied for a sample of 55 HERG, 13 LERG, and 29 RLQ with powerful outflows. The ratio of beam power to disk luminosity tends to be high for LERG, low for RLQ, and spans the full range of
Daly, Ruth A.
core   +1 more source

Cell-Based hERG Channel Inhibition Assay in High-Throughput Format

, 2022
Jinghua Zhao, Menghang Xia, Jinghua Zhao, Menghang Xia   +3 more
openalex   +2 more sources

Antibacterial and Antibiotic‐Enhancing Activity of 3‐Hydroxy‐4‐methoxycinnamic Acid: Experimental Data and In Silico Predictions

ChemistrySelect, Volume 10, Issue 47, December 15, 2025.
ABSTRACT The growing bacterial resistance, driven by the inappropriate use of antibiotics, poses a global health threat and demands new therapeutic strategies. Natural phenolic compounds, such as 3‐hydroxy‐4‐methoxycinnamic acid (3H4MCA), stand out due to their antimicrobial and antioxidant properties, showing potential in combating resistant pathogens.
José Thyálisson da Costa Silva, Viviane Bezerra da Silva, Guilherme Fernandes Teixeira, Carlos Alonso Leite dos Santos, Antonia Adeublena de Araujo Monteiro, Janaína Esmeraldo Rocha, Ewerton Yago de Sousa Rodrigues, Rafael Pereira da Cruz, Isaac Moura Araújo, Adrielle Rodrigues Costa, Cicera Laura Roque Paulo, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais‐Braga, José Maria Barbosa‐Filho, Saulo Almeida de Menezes, Henrique Douglas Melo Coutinho, José Weverton Almeida‐Bezerra   +16 more
wiley   +1 more source

Revealing Molecular Determinants of hERG Blocker and Activator Binding

Journal of Chemical Information and Modeling, 2019
The Kv11.1 potassium channel, encoded by the human ether-a-go-go-related gene (hERG), plays an essential role in the cardiac action potential. hERG blockade by small molecules can induce "torsade de pointes" arrhythmias and sudden death; as such, it is ...
Callum J. Dickson, Camilo Velez-Vega, J. Duca   +2 more
semanticscholar   +1 more source

Multi‐Halogenated Indoles as Antimicrobial and Antivirulence Agents Against Drug‐Resistant Staphylococcus aureus

Microbial Biotechnology, Volume 18, Issue 12, December 2025.
Multi‐halogenated indoles exhibited potent antibiofilm and bactericidal activities against drug‐resistant Staphylococcus aureus by inducing ROS, eradicating persisters and preventing resistance. They suppressed haemolysis and quorum sensing, showed synergy with aminoglycosides and displayed mild cytotoxicity and phytotoxicity, supporting their ...
MinHwi Sim, Bharath Reddy Boya, Yong‐Guy Kim, Jin‐Hyung Lee, Jintae Lee   +4 more
wiley   +1 more source

A minK-HERG complex regulates the cardiac potassium current I(Kr). [PDF]

, 1997
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins.
Fishman, GI, Goldstein, SA, McDonald, TV, Meyers, MB, Ming, Z, Palma, E, Wang, KW, Yu, Z   +7 more
core  

Blockade of the Human Ether A-Go-Go–Related Gene (hERG) Potassium Channel by Fentanyl

Molecular Pharmacology, 2019
The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr). Drug-mediated or medical condition–mediated disruption of hERG function is the primary cause of acquired ...
J. Tschirhart, Wentao Li, Jun Guo, Shetuan Zhang   +3 more
semanticscholar   +1 more source